Journal
MOLECULAR MEDICINE REPORTS
Volume 22, Issue 2, Pages 603-611Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2020.11175
Keywords
diabetes; sugar; insulin resistance; glucose metabolism; lipid metabolism
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Funding
- Basic Scientific Research Projects of Wenzhou Municipal Science and Technology Bureau (CN) [Y20180253]
- NIE HS [T32-E S011564]
- China-U.S. University of Louisville Paediatric Research Exchange Training Program
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Diabetes mellitus (DM) is a growing health concern in society. Type 1 and type 2 DM are the two main types of diabetes; both types are chronic diseases that affect glucose metabolism in the body and the impaired regulation of glucose and lipid metabolism promotes the development and progression of DM. During the physiological metabolism process, the liver serves a unique role in glucose and lipid metabolism. The present article aimed to review the association between DM and glucose metabolism in the liver and discuss the changes of the following hepatic glucose fluxes: Gluconeogenesis, glucose/glucose 6-phosphate cycling, glycogenolysis, glycogenesis and the pentose phosphate pathway. Moreover, the incidence of fatty liver in DM was also investigated.
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