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Biochemistry & Molecular Biology
Joanna Janiszewska, Magdalena Bodnar, Julia Paczkowska, Adam Ustaszewski, Maciej J. Smialek, Lukasz Szylberg, Andrzej Marszalek, Katarzyna Kiwerska, Reidar Grenman, Krzysztof Szyfter, Malgorzata Wierzbicka, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Summary: The study demonstrates that miR-1290 suppresses MAF expression in LSCC, revealing the underlying interaction between the two. Immunohistochemistry staining showed loss of nuclear MAF expression in 58% of LSCC samples. Through data analysis, it was determined that loss-of-function mutations, promoter region DNA methylation or CNV are not responsible for MAF loss in LSCC.
Review
Oncology
Matthew Man-Kin Wong, Sancy Mary Joyson, Heiko Hermeking, Sung Kay Chiu
Summary: AP4 plays a crucial role in cancer by regulating cell fate decisions that impact tumor initiation and progression. It is associated with poor patient prognosis in various tumor types and functions downstream of c-Myc and N-Myc through complex interactions with other molecules.
Article
Biochemistry & Molecular Biology
Eugene Kopantzev, Liya Kondratyeva, Marina Kopantseva, Kirill Kashkin, Dmitry Gnatenko, Elizaveta Grigorieva, Irina Alekseenko, Dina Safina, Igor Chernov
Summary: SOX9 is upregulated in pancreatic ductal adenocarcinoma and plays a crucial role in tumor phenotypes and development. Downregulating the expression of SOX9 in pancreatic cancer cells leads to cell-line-specific changes in protein markers and affects cell proliferation and apoptosis.
Article
Biology
Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao, Feng Qian
Summary: The study showed that Diosmetin has significant inhibitory effects on cell proliferation and can induce cell cycle arrest and apoptosis in osteosarcoma cells. It achieves anti-osteosarcoma effects by regulating the expression of apoptotic proteins and inhibiting the activation of the STAT3/c-Myc signaling pathway.
BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qi Song, Matthew Ruffalo, Ziv Bar-Joseph
Summary: Inference of global gene regulatory networks from omics data is a long-term goal of systems biology. We developed a new computational method that combines neural networks and multi-task learning to predict RNA velocity rather than gene expression values. Application of our method to atlas scale single cell data from 6 HuBMAP tissues led to several validated and novel predictions and greatly improved on prior methods proposed for this task.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Medicinal
Supitchaya Pantia, Thaned Kangsamaksin, Tavan Janvilisri, Waraporn Komyod
Summary: This study aimed to investigate the anticancer effects and mechanisms of Asiatic acid (AA) in nasopharyngeal carcinoma (NPC) cell lines. The results demonstrated that AA inhibited NPC cell viability and migration, and induced cell death by increasing cleaved caspase-3 expression. AA also inhibited STAT3 phosphorylation and reduced claudin-1 expression in NPC cells. Knockdown of STAT3 or claudin-1 enhanced the anti-migratory effect of AA, but did not enhance its anti-proliferative effect. These findings suggest that AA may be a promising candidate for drug development against NPC.
Article
Environmental Sciences
Vimala Karuppaiya, Asaikkutti Annamalai, Shanthi Krishnamurthy, Kannan Soundarapandian
Summary: This study found that the natural substance DCL can inhibit the proliferation and migration of prostate cancer cells by blocking the JAK/STAT3 signaling pathway. The results showed that DCL has significant cytotoxic effects on PC-3 cells and can increase ROS production and apoptotic signals. Additionally, DCL suppresses the expression of proteins that control cell proliferation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Lila Rouland, Eric Duplan, Ligia Ramos dos Santos, Aurore Bernardin, Karen S. Katula, Guidalberto Manfioletti, Ahmed Idbaih, Frederic Checler, Cristine Alves da Costa
Summary: The study demonstrates the tumor suppressor function of Parkin in controlling GBM cell proliferation, with Cyclin A regulated by PK's transcription factor function and Cyclin B by both E3-ligase and transcription factor functions. Invalidation of PK leads to enhanced tumor progression in immunocompetent mice, suggesting an impact of PK-dependent tumor environment. Parkin is secreted by neuronal cells and recaptured by tumor cells, lowering Cyclin levels and decreasing GBM cell proliferation. Additionally, PK expression is decreased in human GBM biopsies and inversely correlated to Cyclin A and Cyclin B expressions.
Article
Oncology
Bin Wang, Qiaohong Gong, Fuhai Chen
Summary: The present study aimed to investigate the role of CDC25A in the progression of nasopharyngeal carcinoma and its potential mechanism. The results showed that CDC25A was highly expressed in NPC cell lines and silencing CDC25A inhibited cell proliferation, reduced the expression levels of Ki67 and PCNA, and induced G(1) arrest. Furthermore, E2F1 was found to bind CDC25A and regulate its expression at the transcriptional level.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Immunology
Qinli Sun, Xiaohong Zhao, Ruifeng Li, Dingfeng Liu, Birui Pan, Bowen Xie, Xinxin Chi, Dongli Cai, Peng Wei, Wei Xu, Kun Wei, Zixuan Zhao, Yujie Fu, Ling Ni, Chen Dong
Summary: Sun et al. discovered that STAT3, activated by IL-10 and IL-21, plays crucial roles in the terminal differentiation of effector CD8(+) T cells in cancer and acute infection. STAT3 enhances effector functions and survival of T-ex(term) cells in the tumor microenvironment, leading to improved tumor control. It transcriptionally promotes effector function-related genes and collaborates with BATF and IRF4 to mediate chromatin activation at effector gene loci.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Renba Liang, Xiaodong Zhu
Summary: UC2288 inhibited the growth of NPC by suppressing the EGFR/ERK pathway and may be a promising therapeutic option for NPC.
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Chao He, Yuanyuan Liu, Jinhou Li, Xiao Zheng, Jianwei Liang, Gang Cui, Hong Chang
Summary: This study found that lncRNA RPSAP52 is highly expressed in gastric cancer cells, and its depletion inhibits cell proliferation, induces apoptosis, and suppresses tumor growth in vivo. MiR-665 was identified as the target of lncRNA RPSAP52, and miR-665 also acts as a negative regulator of STAT3. LncRNA RPSAP52 exerts anti-cancer effects through modulating the miR-665/STAT3 pathway.
Article
Multidisciplinary Sciences
Ya-Qin Wang, Dong-Hong Wu, Denghui Wei, Jia-Yi Shen, Zi-Wei Huang, Xiao-Yu Liang, William C. S. Cho, Jun Ma, Jiawei Lv, Yu-Pei Chen
Summary: By investigating transcription factor-target interactions, researchers identified TEA domain transcription factor 4 (TEAD4) as a master regulator in high-risk nasopharyngeal carcinoma (NPC). TEAD4 promotes NPC progression by inducing migration, invasion, and cisplatin resistance through its autopalmitoylation. This study also reveals that TEAD4's transcriptional activity is independent of its canonical coactivators YAP/ TAZ and serves as an independent predictor of prognosis and treatment response in NPC.
Article
Oncology
Weiyu Dai, Side Liu, Jieming Zhang, Miaomiao Pei, Yizhi Xiao, Jiaying Li, Linjie Hong, Jianjiao Lin, Jing Wang, Xiaosheng Wu, Guangnan Liu, Yaying Chen, Yusi Wang, Zhizhao Lin, Qiong Yang, Fachao Zhi, Guoxin Li, Weimei Tang, Aimin Li, Li Xiang, Jide Wang
Summary: miR-769-5p/miR-769-3p acts as a tumor suppressor in gastric cancer by targeting IGF1R and through the STAT3-IGF1R-HDAC3 complex. Treatment with the HDAC inhibitor SAHA triggers the expression of miR-769-5p/miR-769-3p, leading to inhibition of proliferation and induction of apoptosis in gastric cancer cells.