Review
Oncology
Shantel Angstadt, Qingfeng Zhu, Elizabeth M. Jaffee, Douglas N. Robinson, Robert A. Anders
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with low therapeutic response rates. Current treatments are ineffective due to genetic heterogeneity, early micrometastases, and an immunosuppressive tumor microenvironment. An innovative approach targeting the mechanical properties of cancer cells, specifically PDAC, can simultaneously impact multiple cancer-driving systems. Manipulation of the cell's mechanical system has shown potential for preventing metastasis and regulating oncogenic behaviors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Pharmacology & Pharmacy
Xufeng Tao, Hong Xiang, Yue Pan, Dong Shang, Junchao Guo, Ge Gao, Gary Guishan Xiao
Summary: PDAC is a highly malignant lethal disease that is caused by pancreatitis and involves various pancreatic cells interacting in an inflammation-mediated microenvironment. Understanding the players and their interactions is crucial for the development of effective therapies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
He Xu, Jie Hua, Qingcai Meng, Xiaohong Wang, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Chen Liang, Xianjun Yu, Si Shi
Summary: This study investigated the clinical characteristics and protein landscape of PDAC with hyperdensity. The results showed that patients with hyperdense PDAC had higher microvessel density and better prognosis. Anti-angiogenic therapy may be suitable for these patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Maria Laura Gutierrez, Luis Munoz-Bellvis, Alberto Orfao
Summary: Pancreatic ductal adenocarcinoma (PDAC) remains a malignancy with limited therapeutic options due to its heterogeneous molecular profile. Research on genomic heterogeneity of PDAC has shown impacts on disease behavior and treatment, potentially leading to variable patient outcomes.
Review
Oncology
Zhao Liu, Hiromitsu Hayashi, Kazuki Matsumura, Norio Uemura, Yuta Shiraishi, Hiroki Sato, Hideo Baba
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer type with high metastatic properties and difficulty in early diagnosis. Most PDAC patients have glucose metabolism disorders, which are closely related to the initiation, development, invasion, and metastasis of PDAC. This review provides valuable insights into the clinical and molecular impacts of glycolysis on PDAC research and treatment.
Article
Medicine, General & Internal
Hyung Sun Kim, Kenji Nakagawa, Takahiro Akahori, Kota Nakamura, Tadataka Takagi, Masayuki Sho, Joon Seong Park, Dong Sup Yoon
Summary: A comparative study on neoadjuvant treatment in clinical T1 stage pancreatic cancer patients found no significant difference in overall survival compared to upfront surgery. Large-scale prospective studies are required to determine the survival benefits of neoadjuvant treatment for early-stage pancreatic cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Rong Liu, Ya-Zhou Liao, Wei Zhang, Hong-Hao Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with high heterogeneity and poor survival rates. The study identified specific immune cell types closely associated with the survival rate and chemotherapy sensitivity of PDAC patients, and different immune cell subgroups have different effects on the survival pattern and chemotherapy response of PDAC patients. High expression of PD1 is associated with better overall survival. The study suggests that exploring the immune cellular composition infiltrate in PDAC may help identify candidates for immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Nebojsa Skorupan, Mayrel Palestino Dominguez, Samuel L. Ricci, Christine Alewine
Summary: This review discusses the diverse cell composition and interactions in pancreatic cancer tumors, as well as the impact on cancer cell growth and treatment responses. It also introduces new drug therapies and clinical trials.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Jojanneke Stoof, Emily Harrold, Sarah Mariottino, Maeve A. Lowery, Naomi Walsh
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with DDR deficiency playing an important role in its pathogenesis, yet understanding of these mechanisms is limited. The lack of appropriate laboratory experimental models poses a challenge to preclinical research, despite the potential for high predictivity and effective clinical translation when models effectively recapitulate the original cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yefan Yang, Ying Ding, Yuxi Gong, Sha Zhao, Mingna Li, Xiao Li, Guoxin Song, Boya Zhai, Jin Liu, Yang Shao, Liuqing Zhu, Jiaohui Pang, Yutong Ma, Qiuxiang Ou, Xue Wu, Zhihong Zhang
Summary: This study analyzed the genomic alterations of 151 Chinese patients with head PDAC and found a higher frequency of KRAS G12V mutation in the Chinese population. Additionally, the authors developed a well-performed nomogram that could improve post-operation care in real-world practice.
Article
Oncology
James T. Topham, Joanna M. Karasinska, Michael K. C. Lee, Veronika Csizmok, Laura M. Williamson, Gun Ho Jang, Robert E. Denroche, Erica S. Tsang, Steve E. Kalloger, Hui-li Wong, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Faiyaz Notta, Jonathan M. Loree, Julie M. Wilson, Oliver Bathe, Patricia A. Tang, Rachel Goodwin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, Daniel J. Renouf, David F. Schaeffer
Summary: RNA-sequencing-based subtyping of pancreatic ductal adenocarcinoma (PDAC) using multiple classification tools revealed 12% of tumors with inconsistent subtype calls, showing intermediate survival and molecular characteristics. It is proposed to further investigate the non-binary nature of PDAC subtypes for future clinical practice integration.
CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Sven-Thorsten Liffers, Laura Godfrey, Lisa Frohn, Lena Haeberle, Aslihan Yavas, Rita Vesce, Wolfgang Goering, Friederike Opitz, Nickolas Stoecklein, Wolfram Trudo Knoefel, Anna Melissa Schlitter, Guenter Kloeppel, Elisa Espinet, Andreas Trumpp, Jens T. Siveke, Irene Esposito
Summary: This study provides a comparative morphogenetic analysis of pancreatic ductal adenocarcinoma (PDAC) precursors, revealing the heterogeneity of gastric and intestinal phenotypes at the molecular level, possibly related to different cell identity and etiology.
Article
Oncology
Hsuan-An Chen, Yu-Jui Ho, Riccardo Mezzadra, Jose M. Adrover, Ryan Smolkin, Changyu Zhu, Katharina Woess, Nicholas Bernstein, Georgia Schmitt, Linda Fong, Wei Luan, Alexandra Wuest, Sha Tian, Xiang Li, Caroline Broderick, Ronald C. Hendrickson, Mikala Egeblad, Zhenghao Chen, Direna Alonso-Curbelo, Scott W. Lowe
Summary: Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that stimulates immune clearance of senescent cells. Senescent cells also remodel the cell-surface proteome to alter how tumor cells sense environmental factors, such as type II interferon. This study demonstrates that senescent cells have an enhanced ability to both send and receive environmental signals, which is required for their effective immune surveillance.
Article
Oncology
Yadira M. Soto-Feliciano, Francisco J. Sanchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Summary: Menin interacts with oncogenic MLL1-fusion proteins, and disrupting these interactions can be a potential treatment for leukemia. The study found a molecular switch that determines the response to Menin-MLL inhibitors, involving MLL3/4-UTX chromatin-modifying complexes. By disrupting the Menin-MLL1 interaction, a tumor-suppressive program can be activated, and treatment resistance in leukemia cells can be overcome by using CDK4/6 inhibitors.
Review
Pathology
Burcin Pehlivanoglu, Gizem Akkas, Bahar Memis, Olca Basturk, Michelle D. Reid, Burcu Saka, Nevra Dursun, Pelin Bagci, Serdar Balci, Juan Sarmiento, Shishir K. Maithel, Sudeshna Bandyopadhyay, Oscar Tapia Escalona, Juan Carlos Araya, Hector Losada, Michael Goodman, Jessica Holley Knight, Juan Carlos Roa, Volkan Adsay
Summary: Conflicting data exist regarding the frequency, prognosis and management of pT1b-gallbladder carcinoma (GBC). A study re-evaluated 473 GBC cases from the USA and Chile and found that only 5% of invasive GBCs were pT1b, with a 5-year survival rate of >90%. The study supports the inclusion of pT1b in the early GBC category and highlights the importance of accurate staging and long-term surveillance.
Article
Oncology
Diana Mandelker, Antonio Marra, Nikita Mehta, Pier Selenica, Zarina Yelskaya, Ciyu Yang, Joshua Somar, Miika Mehine, Maksym Misyura, Olca Basturk, Alicia Latham, Maria Carlo, Michael Walsh, Zsofia K. Stadler, Kenneth Offit, Chaitanya Bandlamudi, Meera Hameed, Ping Chi, Jorge S. Reis-Filho, Ozge Ceyhan-Birsoy
Summary: Traditional genetic testing for GISTs focuses on patients with syndromic features. However, expanded genetic testing revealed that 69% of KIT/PDGFRA-wildtype GIST patients had pathogenic/likely pathogenic variants in GIST-associated genes, even without a history of syndromic features. Additionally, somatic variants identified in tumor-only sequencing of GISTs were found to be largely germline in origin.
NPJ PRECISION ONCOLOGY
(2023)
Editorial Material
Oncology
Christine A. Iacobuzio-Donahue
Article
Oncology
Deepti Mathur, Chen Liao, Wendy Lin, Alessandro La Ferlita, Salvatore Alaimo, Samuel Taylor, Yi Zhong, Christine Iacobuzio-Donahue, Alfredo Ferro, Joao B. Xavier
Summary: Understanding the rewired metabolism underlying organ-specific metastasis in breast cancer is essential for improving the treatment and prevention of metastatic disease. A systems biology approach was used to compare metabolic fluxes in breast cancer cells and their derivatives with a tendency to metastasize to the brain or lung. The results showed that lung-homing cells had high glycolytic flux and a strong Warburg effect, associated with a high lactate dehydrogenase to pyruvate dehydrogenase ratio. This ratio was a significant predictor of lung metastasis, independent of other transcriptomic signatures, suggesting its potential as a biomarker.
Meeting Abstract
Medicine, Research & Experimental
David Adsay, Rohat Esmer, Ozgur Eren, Ayse Armutlu, Orhun Taskin, Berke Cesur, Ulkem Kasapoglu, Soner Koc, Nuray Tezcan, Berk Kaan Aktas, Ibrahim Kulac, Yersu Kapran, Olca Basturk, Cigdem Gunduz-Demir, Burcu Saka
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Mustafa Erdem Arslan, Kerem Ozcan, Hulya Sahin Ozkan, Daniela Allende, Funda Yilmaz, Rondell Graham, Raul Gonzalez, Jiaqi Shi, N. Volkan Adsay, Christopher Fletcher, David Klimstra, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Emre Bozkurt, Rohat Esmer, Burcu Saka, Ozgur Eren, Pelin Bagci, Serdar Balci, Ayse Armutlu, Cenk Sokmensuer, Yue Xue, Burcin Pehlivanoglu, Michelle Reid, Shishir Maithel, David Kooby, Juan Sarmiento, Orhun Taskin, Yersu Kapran, Bengi Gurses, Gurkan Tellioglu, Orhan Bilge, Olca Basturk, N. Volkan Adsay
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Esma Ersoy, Aslihan Yavas, Keith Sigel, Nicolas Lecomte, Xianlu Peng, Jen Jen Yeh, Olca Basturk, Carlie Sigel
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Rohat Esmer, Zeynep Tarcan, Kadriye Akar, Pelin Bagci, Nobuyuki Ohike, Keetaek Jang, Emine Bozkurtlar, Burcu Saka, Ayse Armutlu, Orhun Taskin, Serdar Balci, Grace Kim, Yue Xue, Shishir Maithel, Juan Sarmiento, Bahar Memis, Jeanette Cheng, Michelle Reid, Olca Basturk, N. Volkan Adsay
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Kerem Ozcan, Hulya Sahin Ozkan, Pietro Antonini, Claudio Luchini, Burcu Saka, Yue Xue, Michelle Reid, Aldo Scarpa, N. Volkan Adsay, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Kerem Ozcan, Hulya Sahin Ozkan, Laura Tang, Bahar Memis, Grace Kim, Sui Zee, Guoli Chen, Zhaohai Yang, David Klimstra, N. Volkan Adsay, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Article
Biotechnology & Applied Microbiology
Palash Sashittal, Haochen Zhang, Christine A. Iacobuzio-Donahue, Benjamin J. Raphael
Summary: This article introduces a new evolutionary model and algorithm, ConDoR, for inferring phylogeny in tumors. The model uses SNVs as phylogenetic markers and constrains losses of SNVs according to clusters of cells. The advantages of ConDoR are demonstrated through simulations and real data.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
