Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 64, Issue 6, Pages 469-475Publisher
WILEY
DOI: 10.1111/1348-0421.12791
Keywords
Bordetella pertussis; BvgAS; gene regulatory system; in vivo RNA sequencing; small RNA
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Funding
- Japan Society for the Promotion of Science [17H04075, 19K16638, 19K23845]
- JSPS KAKENHI
- Grants-in-Aid for Scientific Research [17H04075, 19K16638, 19K23845] Funding Source: KAKEN
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We performed RNA sequencing on Bordetella pertussis, the causative agent of whooping cough, and identified nine novel small RNAs (sRNAs) that were transcribed during the bacterial colonization of murine tracheas. Among them, four sRNAs were more strongly expressed in vivo than in vitro. Moreover, the expression of eight sRNAs was not regulated by the BvgAS two-component system, which is the master regulator for the expression of genes contributing to the bacterial infection. The present results suggest a BvgAS-independent gene regulatory system involving the sRNAs that is active during B. pertussis infection.
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