Review
Food Science & Technology
Jiangmin Shi, Qinjian Wang, Gaoyi Ruan, Yaoxuan Chen, Min Zhao, Dibang Shi, Binhui Pan, Zhihua Xu, Tiaotiao Zhang, Fangyan Wang, Changlong Xu
Summary: This meta-analysis found that treatment with probiotics significantly reduced noncavitated and cavitated carious lesions in children. Probiotics also reduced the prevalence of noncavitated carious lesions. Salivary Streptococcus mutans was decreased after intervention, while Lactobacillus counts were increased. Our findings suggest that probiotics, especially Lactobacillus, could be a promising therapeutic strategy for dental caries in children.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jingheng Liang, Yan Zhou, Guihua Tang, Ruixue Wu, Huancai Lin
Summary: This study found that the cell-free supernatant of Lactobacillus plantarum has a strong antibiofilm effect on Streptococcus mutans, and the main antibiofilm substance is a mixture of lactic acid and valine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Junyuan Luo, Zening Feng, Xiaohui Lyu, Linglin Zhang
Summary: This study investigated the effects of LF-1, a lactotransferrin-derived antimicrobial peptide, on the cariogenic virulence factors of Streptococcus mutans. LF-1 inhibited the growth and key enzymatic activity of S. mutans, as well as downregulated virulence-associated gene expression. These findings suggest that LF-1 has promising application prospects in combating S. mutans and dental caries.
Article
Biochemistry & Molecular Biology
Morteza Banakar, Maryam Pourhajibagher, Shahroo Etemad-Moghadam, Majid Mehran, Mohammad Hossein Yazdi, Roza Haghgoo, Mojgan Alaeddini, Roland Frankenberger
Summary: This research evaluated the antimicrobial/antibiofilm activity of postbiotic mediators (PMs) derived from Lactobacillus rhamnosus GG (LGG) and Lactobacillus reuteri (LR) against Streptococcus mutans in vitro. The results showed that these PMs reduced the formation and metabolic activity of S. mutans, and downregulated the expression of the gtfB gene. Therefore, these derivatives may serve as suitable antimicrobial agents.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Chemistry, Multidisciplinary
Amit Wolfoviz-Zilberman, Yael Houri-Haddad, Nurit Beyth
Summary: In vitro and in vivo models were compared in this study to evaluate anti-caries modalities for prevention and treatment. The developed in vitro caries model demonstrated rapid caries development within 5 days, especially in the depth of occlusal fissures in the control group. This model may provide a novel animal-sparing approach for caries disease studies and assessing the efficacy of antibacterial dental materials.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Yan Zeng, Ahmed Fadaak, Nora Alomeir, Tong Tong Wu, Elena Rustchenko, Shuang Qing, Jianhang Bao, Christie Gilbert, Jin Xiao
Summary: This study assessed the effects of four probiotic Lactobacillus strains on cariogenic bacteria-fungi biofilm formation and their interactions. Lactobacillus plantarum demonstrated superior inhibition on the growth of Candida albicans and Streptococcus mutans, disrupted virulent biofilm formation, and downregulated genes involved in metabolic pathways and antifungal resistance. These findings support further evaluation of L. plantarum for controlling cariogenic biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Xiaoying Lyu, Chungen Li, Jin Zhang, Liang Wang, Qingsong Jiang, Yusen Shui, Lan Chen, Youfu Luo, Xin Xu
Summary: The study introduced a novel small molecule, LCG-N25, derived from NAP, which exhibited promising antimicrobial activity against cariogenic bacteria without inducing drug resistance. This new compound could potentially serve as an effective adjuvant in the management of dental caries.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Muna Aqawi, Ronit Vogt Sionov, Ruth Gallily, Michael Friedman, Doron Steinberg
Summary: The study demonstrated that Cannabigerol (CBG) can effectively prevent the formation of Streptococcus mutans biofilms, reduce biofilm thickness and metabolic activity, and alter the surface roughness of the biofilms. CBG also decreased the expression of genes related to S. mutans biofilm formation, indicating its potential as a preventive treatment for dental caries.
Article
Nutrition & Dietetics
Xinyan Huang, Jianhang Bao, Yan Zeng, Gina Meng, Xingyi Lu, Tong Tong Wu, Yanfang Ren, Jin Xiao
Summary: Ecological approaches can correct oral microbial dysbiosis and promote symbiotic oral microbiome for long-term dental caries control. The study found that prebiotics Galacto-oligosaccharide (GOS) inhibited the growth of Streptococcus mutans and Candida albicans and enhanced the anti-fungal performance of L. plantarum. GOS also resulted in a less acidic environment and reduced expression of virulence genes in S. mutans and C. albicans.
Article
Infectious Diseases
Lucia Martinez-Lamas, Eliane Garcia-Mato, Anniris Rincon-Quintero, Berta Rivas-Mundina, Pedro Diz-Dios, Maximiliano Alvarez-Fernandez
Summary: This study assessed the potential mechanisms by which S. downii exerts its inhibitory effect on S. mutans and found that the main mechanism is the production of bacteriocins.
Article
Microbiology
Hyeoungeun Kim, Chi-Young Han, Su-Hyeon Eun, Min-Goo Kim, A-Rang Im, Byeonghun Lee
Summary: This study demonstrates the potential of the Bacillus velezensis ID-A01 supernatant for the prevention and treatment of dental caries. Its eventual use in dental practice is encouraged, although further studies are required to confirm its beneficial effects.
Article
Chemistry, Multidisciplinary
Leandro W. Figueira, Beatriz H. D. Panariello, Cristiane Y. Koga-Ito, Simone Duarte
Summary: Low exposure times of low-temperature plasma affect the viability of single- and multi-species cariogenic biofilms, showing promising potential for the development of new protocols for the control of dental caries.
APPLIED SCIENCES-BASEL
(2021)
Article
Microbiology
Muna Aqawi, Ronit Vogt Sionov, Ruth Gallily, Michael Friedman, Doron Steinberg
Summary: CBG exhibits antibacterial activities against S. mutans by altering membrane structures and properties, increasing membrane permeability, reducing metabolic activity, and preventing pH drop caused by the bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Education, Scientific Disciplines
Vaishnavi Vedam, Gokul Shankar Sabesan, Arun Kumar Adhikary, Subramani Parasuraman
Summary: This review provides insights into the role of individual strains of Lactobacillus probiotics in combating Streptococcus mutans associated with dental caries. It highlights the importance of commercially approved oral probiotic products using exclusive lactobacillus strains. The review also discusses the pathogenesis, commercial products, and future perspectives in the treatment of dental caries.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zening Feng, Junyuan Luo, Xiaohui Lyu, Yue Chen, Linglin Zhang
Summary: The study confirms the selective affinity and antibacterial activity of LF-1 against S. mutans, highlighting its potential as a crucial antibacterial agent in caries prevention.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nathan das Neves Selis, Hellen Braga Martins de Oliveira, Yan Bento dos Anjos, Hiago Ferreira Leao, Beatriz Almeida Sampaio, Thiago Macedo Lopes Correia, Mariane Mares Reis, Thamara Louisy Santos Brito, Carolline Florentino Almeida, Larissa Silva Carvalho Pena, Lais Ferraz Brito, Roberta Maria Ornelas, Tiza Teles Santos, Guilherme Barreto Campos, Jorge Timenetsky, Mariluze Peixoto Cruz, Andrea Miura da Costa, Regiane Yatsuda, Ana Paula Trovatti Uetanabaro, Lucas Miranda Marques
Summary: This study evaluated the potential probiotic effects of five Lactobacillus strains isolated from cupuacu fruit fermentation against vaginal pathogens. The results demonstrated the ability of the lactobacilli to inhibit the growth of Gardnerella vaginalis and Neisseria gonorrhoeae, indicating their potential as probiotics for vaginal health. Additionally, the strains showed biofilm production, antimicrobial activity, and the production of lactic acid as the most abundant organic acid, suggesting their promising application in supporting vaginal health.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Camila do Nascimento Araujo, Aline Teixeira Amorim, Maysa Santos Barbosa, Julieta Canjimba Porto Lucas Alexandre, Guilherme Barreto Campos, Claudia Leal Macedo, Lucas Miranda Marques, Jorge Timenetsky
Summary: The study analyzed the presence of Mollicutes, Mycoplasma hyorhinis, Fusobacterium nucleatum, and Helicobacter pylori in gastric cancer tissues, with Mollicutes being correlated with papillary histologic pattern, H. pylori being associated with metastasis and other factors, and F. nucleatum as a cancer risk factor.
INFECTIOUS AGENTS AND CANCER
(2021)
Article
Agriculture, Dairy & Animal Science
Maysa Santos Barbosa, Joachim Spergser, Lucas Miranda Marques, Jorge Timenetsky, Renate Rosengarten, Rohini Chopra-Dewasthaly
Summary: This study used MALDI-ToF MS analysis to examine the differences between Mycoplasma agalactiae strains PG2 and GM139, and evaluated their Vpma phenotypic profiles. The results show that GM139 predominantly expresses VpmaV without phase variation, which may contribute to its differential pathogenicity compared to PG2.
Article
Microbiology
Maysa Santos Barbosa, Lucas Miranda Marques, Jorge Timenetsky, Renate Rosengarten, Joachim Spergser, Rohini Chopra-Dewasthaly
Summary: To summarize, the hypothetical protein corresponding to MAG_6130 has not only been assigned novel adhesion functions but together with P40 it is demonstrated for the first time to bind to lactoferrin and ECM proteins thereby playing important roles in host colonization and pathogenicity.
Article
Microbiology
Verena M. Santos, Anne Karoline P. Brito, Aline T. Amorim, Izadora R. Souza, Maysa B. Santos, Guilherme B. Campos, Deborah C. dos Santos, Antonio Carlos R. Braga Junior, Jerusa M. Santana, Djanilson B. Santos, Marcio C. Mancini, Jorge Timenetsky, Lucas M. Marques
Summary: The present study evaluated the gut microbiota profiles of 40 women and found that gut microbiota was associated with obesity in women, and it was also related to inflammatory profiles and alterations in ghrelin and leptin levels.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thiago Macedo Lopes Correia, Amanda Alves Almeida, Danielba Almeida da Silva, Raildo da Silva Coqueiro, Ramon Alves Pires, Amelia Cristina Mendes de Magalhaes, Raphael Ferreira Queiroz, Lorena Lobo Brito, Lucas Miranda Marques, Marco Machado, Rafael Pereira
Summary: Regular physical training and cigarette smoke exposure have opposite effects on physical performance, antioxidant defense, and inflammatory profile. CSE attenuates the benefits of physical training, while promoting harmful pro-inflammatory effects and impairing antioxidant defense.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Bruno Oliveira Moreira, Vanessa Lima Souza Vilar, Ramine Nascimento Santos de Almeida, Lorena Lobo Brito Morbeck, Bruno Silva Andrade, Rafael Gomes Moreno Barros, Breno Magalhaes Neves, Anaildes Lago de Carvalho, Mariluze Peixoto Cruz, Regiane Yatsuda, Jorge Mauricio David
Summary: Schinopsis brasiliensis, an endemic tree of Brazil, has been widely used in Brazilian folk medicine for its anti-inflammatory and analgesic activities. This study isolated two new compounds and reported their acetylcholinesterase inhibitory activity for the first time. Molecular docking studies suggested that these compounds may interact with anti-inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
Manoel Neres Santos-Junior, Wanderson Souza Neves, Ronaldo Silva Santos, Palloma Porto Almeida, Janaina Marinho Fernandes, Bruna Carolina de Brito Guimaraes, Maysa Santos Barbosa, Lucas Santana Coelho da Silva, Camila Pacheco Gomes, Beatriz Almeida Sampaio, Izadora de Souza Rezende, Thiago Macedo Lopes Correia, Nayara Silva de Macedo Neres, Guilherme Barreto Campos, Bruno Lopes Bastos, Jorge Timenetsky, Lucas Miranda Marques
Summary: Ureaplasma diversum is a bacterial pathogen that infects cattle and can cause severe inflammation of the genital and reproductive systems. In this study, the researchers successfully expressed and purified recombinant GUDIV-103 (rGUDIV-103) and demonstrated its immunoreactivity and immunomodulatory effects in bovine peripheral blood mononuclear cells (PBMCs). They also showed that rGUDIV-103 induced lymphocyte proliferation and increased the expression of immune-related genes. These findings suggest that rGUDIV-103 has potential applications in immunobiology.
Article
Virology
Anna Carolina S. Dantas, Hellen B. M. Oliveira, Camila P. Gomes, Daniele L. Alves, Priscilla D. B. Infante, Rosimara de J. A. Caitite, Hegger M. Fritsch, Marina S. Cucco, Lucas S. C. Silva, Caline N. T. Oliveira, Rafaela de S. Bittencourt, Aline T. Amorim, Ana Luisa P. Nascimento, Francely A. G. C. Marinho, Danielle S. de Medeiros, Marcio G. G. de Oliveira, Sostenes Mistro, Fabricio F. de Melo, Taiana T. S. Pereira, Ana M. S. Guimaraes, Jorge Timenetsky, Pablo Maciel B. Moreira, Sandra Helena P. de Oliveira, Luiz C. J. Alcantara, Marta Giovanetti, Luciane A. Santos, Vagner Fonseca, Fernanda K. Barreto, Guilherme B. Campos, Lucas M. Marques
Summary: This study aimed to identify risk factors for mortality from SARS-CoV-2 infection, evaluate gene expression patterns of immune response pathways in COVID-19 patients, and identify circulating SARS-CoV-2 variants in a medium-sized city in Northeast Brazil. The study found that pre-existing comorbidity, male gender, cardiovascular disease, diabetes, chronic obstructive pulmonary disease, and PCR cycle threshold values under 22 were identified as risk factors for mortality. Furthermore, the study demonstrated that the severity of infection was associated with increased activation of inflammatory pathways, and multiple lineages of the virus were circulating.
Article
Microbiology
Aline Teixeira Amorim, Vanesca de Souza Lino, Lucas Miranda Marques, Davi Jardim Martins, Antonio Carlos Ricardo Braga Junior, Guilherme Barreto Campos, Caline Novais Teixeira Oliveira, Enrique Boccardo, Jorge Timenetsky
Summary: Mycoplasma hominis infection affects the cell cycle and inflammatory response of human keratinocytes. Infection leads to cellular damage, activates cell cycle regulation and apoptosis progression, increases oxidative stress response, activates Toll-like receptor pathways, and results in reduced cell proliferation/viability.
Article
Multidisciplinary Sciences
Lais Ferraz Brito Sousa, Hellen Braga Martins Oliveira, Nathan das Neves Selis, Lorena Lobo Brito Morbeck, Talita Costa Santos, Lucas Santana Coelho da Silva, Jully Chayra Santos Viana, Mariane Mares Reis, Beatriz Almeida Sampaio, Guilherme Barreto Campos, Jorge Timenetsky, Regiane Yatsuda, Lucas Miranda Marques
Summary: The study evaluated the biological activities of the BCP-DHA combination in in vitro and in vivo experimental models of antinociception and inflammation. The results showed that BCP-DHA had significant anti-inflammatory and antinociceptive effects.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Valdiele de Jesus Salgado, Caio Marcellus Pereira de Abreu Oliveira, Agatha Morgana Bertoti da Silva, Henrique Inacio Lima de Brito, Danielle Souto de Medeiros, Fabiane Soares, Laio Magno, Ines Dourado, Guilherme Barreto Campos, Lucas Miranda Marques
Summary: This study investigated the prevalence of Mollicutes among adolescent MSM and TGW aged 15 to 19. The results showed a high prevalence of infection at extragenital sites. Further research is needed to understand the epidemiological characteristics of high-risk adolescents in different regions and contexts, as well as the pathogenesis of Mollicutes in the oral and anal mucosa.
BMC INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Deborah Cruz Dos Santos, Rafaela de Souza Bittencout, Iago Dorea Areas, Larissa Silva C. Pena, Carolline Florentino Almeida, Bruna Carolina de Brito Guimaraes, Rafael Santos Dantas Miranda Dorea, Thiago Macedo Lopes Correia, Manoel Neres Santos Junior, Lorena Lobo Brito Morbeck, Talita Costa Dos Santos, Clarissa Leal S. Souza, Samira Itana de Souza, Telma de Jesus Soares, Regiane Yatsuda, Guilherme Barreto Campos, Lucas Miranda Marques
Summary: This study evaluated the influence of the hormone 5-alpha-dihydrotestosterone (DHT) on the immune response of mouse peritoneal macrophages (MPMs) and human peripheral blood monocytes (HPBMs) induced by Staphylococcus aureus (S. aureus) infection. The results showed that DHT acts as an inflammatory modulator in the monocyte/macrophage response induced by S. aureus, and females exhibit a better immune defense response against this pathogen.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Medicine, General & Internal
Fillipe Dantas Pinheiro, Luana Weber Lopes, Rafael Santos Dantas Miranda Dorea, Glauber Rocha Lima Araujo, Filipe Antonio Franca da Silva, Breno Bittencourt de Brito, Maria Luisa Cordeiro Santos, Geovani Moreno Santos Jr, Maria Teresa Araujo de Lorenzo Barcia, Renata de Amorim Marques, Andre Bezerra Botelho, Anna Carolina Saude Dantas, Davi Tanajura Costa, Adriano Fernandes Teixeira, Claudio Lima Souza, Lucas Miranda Marques, Guilherme Barretos Campos, Marcio Vasconcelos Oliveira, Dulciene Maria de Magalhaes Queiroz, Fabricio Freire de Melo
Summary: This study investigated the epidemiological and clinical features of severely ill COVID-19 patients in an intensive care unit in northeastern Brazil. Results showed that dyspnea was the most frequent symptom, affecting 73.9% of patients, followed by cough (54.7%). The presence of two or more comorbidities increased the risk of mortality, and lower platelet count was positively associated with death. Nausea and vomiting were two symptoms that predicted death, while the presence of a cough was a protective factor.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Public, Environmental & Occupational Health
Mateus Rodrigues Westin, Yuppiel Franmil Martinez, Ana Paula Silva, Marilia Greco, Lucas Miranda Marques, Guilherme Barreto Campos, Matheus de Paula Alves, Alessandra Mancuzzo, Unai Tupinambas, Dirceu Bartolomeu Greco
Summary: Syphilis is a significant public health problem in Brazil and globally, particularly affecting MSM and TrTGW. There is limited research on STIs in adolescents from these key populations. This Brazilian multi-center study focused on sexually active MSM and TrTGW adolescents and found a high prevalence of syphilis. Risk factors included STI history, sex work, and low education level. This study highlights the urgent need to strengthen public health programs addressing race, gender, sexuality, and prevention.
CADERNOS DE SAUDE PUBLICA
(2023)