Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Review
Neurosciences
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Xingyu Zhang, Ye Yuan, Zongyi Xie
Summary: This review outlines the role of microglial pyroptosis in the pathological process of intracerebral hemorrhage (ICH) and highlights the potential of targeted strategies to inhibit microglial pyroptosis as a therapeutic approach.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Clinical Neurology
Fangke Xie, Qiang Tan, Anyong Yu, Peiwen Guo, Ling Wang, Zongwei Zeng, Liang Liang, Jishu Xian, Hua Feng, Zhi Chen
Summary: The presence of cfDNA in clots was observed shortly after intraventricular hemorrhage, and it was found to impair the fibrinolysis effects of tPA. Degradation of cfDNA by DNase1 enhanced fibrinolysis and improved functional outcomes, suggesting that targeting cfDNA degradation may be a promising approach to treat intraventricular hemorrhage.
JOURNAL OF NEUROSURGERY
(2021)
Review
Immunology
Ruiyi Zhang, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with a poor prognosis. Despite numerous pre-clinical studies and clinical trials, effective treatment for ICH patients is still lacking. Minocycline, a neuroprotective pharmaceutical, shows promise in alleviating secondary brain injury after ICH. This review discusses the protective mechanisms, limitations, and clinical trial perspectives of minocycline in ICH, aiming to facilitate further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ziping Han, Lingzhi Li, Zhen Tao, Rongliang Wang, Haiping Zhao, Yangmin Zheng, Zhenhong Yang, Liyuan Zhong, Junfen Fan, Yumin Luo
Summary: There is a correlation between the levels of noncoding RNAs (miRNA-23a, miRNA-99a, and lncRNA H19) and the outcomes of acute ischemic stroke (AIS) patients before and after treatment with IV recombinant tissue plasminogen activator (rtPA). A noncoding RNA score composed of miRNA-23a, miRNA-99a, and lncRNA H19 can predict the functional outcome and the occurrence of symptomatic intracerebral hemorrhage (sICH) after rtPA treatment in AIS patients. These findings suggest that miRNA-23a, miRNA-99a, and lncRNA H19 may have independent predictive value in thrombolysis after AIS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Xiaoxi Li, Heyu Zhang, Wenxu Zheng, Jizhou Sun, Liyuan Wang, Zhiyi He
Summary: Intracerebral hemorrhage (ICH) has a poor prognosis and high mortality rates. Ozanimod, a selective sphingosine 1-phosphate receptor modulator, can mitigate the secondary inflammatory response and improve neurological functions in ICH mice by modulating the SIRT3/NF-kappa B/AIM2 pathway, indicating its potential as a targeted therapy for improving ICH prognosis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Lingui Gu, Mingjiang Sun, Ruihao Li, Xingyu Zhang, Yihao Tao, Ye Yuan, Xu Luo, Zongyi Xie
Summary: Didymin treatment significantly improved neurobehavioral performance, reduced BBB disruption and brain water content, and mitigated microglial activation and neutrophil infiltration in the peri-hematoma tissue after ICH. The upregulation of Rkip expression by Didymin may play a key role in alleviating microglial pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Ting Yang, Hongfei Jing, Yungang Cao, Xianda Lin, Jueyue Yan, Meijuan Xiao, Xiaoyan Huang, Zicheng Cheng, Zhao Han
Summary: The study found that patients with different subtypes of ICH after r-tPA treatment have different clinical outcomes. Specifically, the PH-2 subtype is significantly associated with early neurological deterioration and increased mortality at the third month.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Clinical Neurology
Zhe Li, Suliman Khan, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Stroke is the second leading cause of death worldwide, and intracerebral hemorrhage (ICH) is a type of stroke associated with poor neurological outcomes and high mortality. Experimental therapies have shown potential in improving functional outcomes for ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Christopher R. Green, J. Claude Hemphill
Summary: This article reviews the association between hypertension and stroke, discusses current guidelines for early blood pressure management, and highlights the need for further trials to determine the effects of blood pressure control in specific patient populations.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Neurosciences
Linglong Xiao, Mengqi Wang, Yifeng Shi, Yangyang Xu, Yuan Gao, Wei Zhang, Yang Wu, Hao Deng, Wei Pan, Wei Wang, Haitao Sun
Summary: Intracerebral hemorrhage (ICH) is a neurological disease that causes high mortality and disability. White matter injury (WMI) plays a significant role in motor dysfunction after ICH. Neuroinflammation mediated by NLRP3 inflammasome activation exacerbates secondary WMI after ICH. Inhibition of NLRP3 inflammasome activation may attenuate WMI by polarizing microglia and astrocytes to an anti-inflammatory phenotype following ICH.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Naomi Inoue, Aki Kato, Takashi Araki, Takeshi Kimura, Takamasa Kinoshita, Fumiki Okamoto, Tomoya Murakami, Yoshinori Mitamura, Taiji Sakamoto, Akiko Miki, Yoshihiro Takamura, Hisashi Matsubara, Hiroki Tsujinaka, Fumi Gomi, Tsutomu Yasukawa
Summary: The clinical features, treatment options, and visual outcomes of SMHs secondary to nAMD were investigated. The study found that vitrectomy or pneumatic displacement is recommended for visual improvement in patients with SMHs exceeding 2 disc area and with BCVA below 20/40.
Article
Biochemistry & Molecular Biology
Minshu Li, Xiuping Li, Dan Wang, Xiaolin Gao, Shiyao Li, Xiaojing Cheng, Yiming Shen, Shenghui Li, Qiang Jia, Qiang Liu
Summary: Inhibition of exosome release exacerbates neuroinflammation and ICH injury by increasing leukocyte infiltration into the brain and barrier disruption. However, exosomes extracted from the ICH brain can reduce ICH injury in recipient mice, showing potential neuroprotective effects. Further investigation into the impact of exosomes released from the ICH brain on the immune system is warranted.
Article
Biochemistry & Molecular Biology
Wendy C. Ziai, Adrian R. Parry-Jones, Carol B. Thompson, Lauren H. Sansing, Michael T. Mullen, Santosh B. Murthy, Andrew Mould, Saman Nekoovaght-Tak, Daniel F. Hanley
Summary: The study investigated the expression of inflammatory cytokines in cerebrospinal fluid and their relationship with disease severity in patients with acute IVH. Results showed that some inflammatory cytokine levels peaked earlier in IVH patients, with positive correlations with IVH and ICH volumes. Time trends of cytokines support the association of cerebral inflammatory responses with the severity of ICH/IVH.
Article
Environmental Sciences
Iva Justinic, Ana Katic, Deni Ursicic, Bozena Curko-Cofek, Branka Blagovic, Gordana Canadi Juresic
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Anesthesiology
Ana Piculjan, Marko Sustic, Gordana Brumini, Janja Kuharic, Alan Sustic
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2020)
Review
Nutrition & Dietetics
Tanja Grubic Kezele, Bozena Curko-Cofek
Article
Microbiology
Gordana Canadi Juresic, Bozena Curko-Cofek, Martina Barbaric, Nermina Mumisi, Branka Blagovic, Polona Jamnik
Summary: Iron and lead have specific patterns of toxicity and stress response on yeast cells, with lead showing lower metabolic activity compared to iron. The effects of these metals were also reflected in the efficiency of endogenous antioxidant defense systems and mitochondrial proteome composition.
CURRENT MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Nada Starcevic Cizmarevic, Bozena Curko-Cofek, Vesna Barac-Latas, Borut Peterlin, Smiljana Ristic
Summary: Increasing evidence supports the potential role of iron metabolism in multiple sclerosis (MS). However, a meta-analysis of 7 studies conducted in Caucasian populations found no significant association between the C282Y and H63D polymorphisms in the HFE gene and MS risk. Further studies are needed to evaluate the contribution of HFE and other genetic variants associated with iron regulation in the development and progression of MS.
BIOMEDICAL REPORTS
(2022)
Meeting Abstract
Rheumatology
V. Drvar, D. Legovic, B. Curko-Cofek, D. Rukavina, E. Babarovic, T. Kehler, V. Persic, G. Laskarin
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Nutrition & Dietetics
Tanja Grubic Kezele, Bozena Curko-Cofek
Summary: Olive polyphenols have beneficial effects in the prevention and treatment of neurological diseases such as multiple sclerosis and stroke. They can alleviate inflammation and oxidative stress, reduce the risk of stroke, and have positive effects on obese individuals.
Article
Medicine, Research & Experimental
Vedrana Drvar, Dalen Legovic, Gordana Anadi Juresic, Bozena Curko-Cofek, Tatjana Kehler, Ana-Marija Laskarin, Emilio Nemcic, Gordana Laskarin
Summary: This study aims to investigate the immune mechanisms initiated by 7-KCh in the synovial fluid of patients with osteoarthritis, and to analyze the polarization and tissue distribution of synovial CD68+ cells in relation to T cells and NK cells. Furthermore, the study will explore the influence of 7-KCh on the phenotype and intracellular cytokine and chemokine production in suspension.
MEDICAL HYPOTHESES
(2023)
Letter
Medicine, General & Internal
Smiljana Ristic, Sandra Milic, Tanja Tatalovic, Matea Bilobrk, Dobrica Roncevic, Bozena Curko-Cofek, Vesna Barac-Latas, Nada Starcevic Cizmarevic
BALKAN MEDICAL JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Danijel Knezevic, Bozena Curko-Cofek, Tanja Batinac, Gordana Laskarin, Marijana Rakic, Maja Sostari, Marko Zdravkovic, Alan Sustic, Vlatka Sotosek, Lara Baticic
Summary: Cardiac surgery is a high-risk procedure that often leads to endothelial injury and subsequent organ dysfunction. This review focuses on the structure and function of the endothelial glycocalyx and shedding mechanisms in cardiac surgery, as well as potential strategies to protect and restore it. Additionally, the latest evidence on biomarkers of endothelial dysfunction and their clinical implications in cardiac surgery patients is summarized.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Tatjana Bogovic Crncic, Neva Girotto, Maja Ilic Tomas, Ines Kristofic, Sanja Klobucar, Lara Baticic, Bozena Curko-Cofek, Vlatka Sotosek
Summary: Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disorder, and hormonal changes during pregnancy can worsen the course of AITD. Previous thyroid disorders can also affect pregnancy outcomes. Therefore, maintaining thyroid equilibrium is crucial for pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
V. E. D. R. A. N. A. DRVAR, B. O. Z. E. N. A. CURKO-COFEK, L. J. E. R. K. A. KARLEUSA, M. E. R. I. C. A. ARALICA, M. A. R. I. J. A. ROGOZNICA, T. A. T. J. A. N. A. KEHLER, D. A. L. E. N. LEGOVIC, D. A. N. I. E. L. RUKAVINA, G. O. R. D. A. N. A. LASKARIN
Summary: This study found that GNLY expression and GNLY-mediated early apoptosis of K-562 targets are increased in patients with knee OA compared to controls, accompanied by intracellular dominance of IFN-gamma over IL-4 in NK cells.
BIOMEDICAL REPORTS
(2022)
Meeting Abstract
Rheumatology
G. Laskarin, T. Kehler, D. Legovic, V. Santic, B. Curko-Cofek, V. Drvar, M. Rogoznica, D. Rukavina
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Medicine, General & Internal
Mirna Krkovic, Andrea Koosova Gajic, Janja Tarcukovic, Vlatka Sotosek, Tea Stimac, Sanja Balen, Boban Dangubic, Igor Grubjesic
AMERICAN JOURNAL OF CASE REPORTS
(2020)