Journal
MEDICINAL RESEARCH REVIEWS
Volume 40, Issue 5, Pages 1754-1775Publisher
WILEY
DOI: 10.1002/med.21669
Keywords
cancer therapy; carrier-free; nanosystem; pure drug; self-assembly
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Funding
- National Natural Science Foundation of China [81703451, 81773656]
- Key projects of Liaoning Province Department of Education [2017LZD03]
- Key projects of Technology bureau in Shenyang [18400408]
- Liaoning Revitalization Talents Program [XLYC1808017, XLYC1907129]
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The potential toxicity of nanocarrier excipients and complicated preparation technologies have impeded the clinical application of nanomedicine. Recently, pure drug-assembled nanosystems (PDANS) have been widely investigated, due to the unique self-assembly characteristics of pure drug molecules. PDANS provides a facile nanoplatform for developing carrier-free nanomedicine. Herein, the recent trends in PDANS for cancer therapy are outlined. First, the emerging strategies to develop single pure drug-based nanoassemblies are discussed. Second, co-assembly of two or more pure drugs for efficient combination therapy is overviewed. Then, the functional self-assembly of non-cytotoxic agents in tumor sites is presented. Finally, the rational design and self-assembly mechanisms of these unique nanoplatforms are highlighted.
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