Article
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Sunyoung Lee, Jaeseung Shin, Won Jeong Son, Hyejung Shin, Ji Eun Lee, Jeong Ah Hwang, Yong Eun Chung, Jin-Young Choi, Mi-Suk Park
Summary: The study systematically compared the performance of CT/MRI LI-RADS category 5 (LR-5) for diagnosing HCC between 2017 and 2018 versions, finding no significant difference in sensitivity and specificity between the two versions. The most common underlying liver disease (hepatitis B or hepatitis C) was a significant factor contributing to the heterogeneity of sensitivities among studies for both versions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jaeseung Shin, Sunyoung Lee, Ja Kyung Yoon, Yun Ho Roh
Summary: This study aimed to compare the performance of the 2018 European Association for the Study of the Liver (EASL) criteria and the Liver Imaging Reporting and Data System (LI-RADS) criteria for noninvasive diagnosis of hepatocellular carcinoma (HCC). The results showed that there were no significant differences in sensitivity and specificity between the EASL criteria and LI-RADS criteria. Subgroup analyses also showed no significant differences for different size observations.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Sunyoung Lee, Jaeseung Shin, Won Jeong Son, Yun Ho Roh, Jeong Ah Hwang, Ji Eun Lee
Summary: Comparative studies were conducted to compare the performance of Liver Imaging Reporting and Data System category 5 (LR-5) for diagnosing HCC between CT and MRI. The results showed that MRI had significantly higher sensitivity than CT in diagnosing HCC using LR-5. However, there was no significant difference in specificity between the two modalities. Subgroup analysis revealed that extracellular contrast agent-enhanced MRI had higher sensitivity than gadoxetic acid-enhanced MRI in diagnosing HCC.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhaoxia Yang, Ying Gong, Min Ji, Bin Yang, Zhongwei Qiao
Summary: Features including age <= 5 years, elevated serum AFP, larger size, ill-defined border, calcification, absence of haemorrhage, intratumoural vessel, peripancreatic vessel invasion, distant metastasis, and lower ADC value can help differentiate PB from SPN in children. SPNs have higher ADC values compared to PB. There were no significant differences in terms of tumour capsule, pancreatic duct dilatation, or cystic degeneration area over 50% of the tumour volume between the two groups.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sunyoung Lee, Seung-seob Kim, Heejin Bae, Jaeseung Shin, Ja Kyung Yoon, Myeong-Jin Kim
Summary: Identifying significant ancillary features in LI-RADS 2018 and developing upgraded LR-5 criteria incorporating these features can improve sensitivity without impairing specificity for the noninvasive diagnosis of HCC on gadoxetic acid-enhanced MRI.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Article
Gastroenterology & Hepatology
Carlos Moctezuma-Velazquez, Sara Lewis, Karen Lee, Salvatore Amodeo, Josep M. Llovet, Myron Schwartz, Juan G. Abraldes, Augusto Villanueva
Summary: The study evaluated the performance of EASL and LI-RADS criteria for diagnosing HCC in non-cirrhotic patients with chronic HBV infection. The criteria showed a positive predictive value comparable to that seen in patients with cirrhosis when the pre-test probability of HCC is >70%. These criteria could be used for diagnosing HCC in non-cirrhotic patients with HBV.
Article
Health Care Sciences & Services
Simone van der Star, Pim A. de Jong, Madeleine Kok
Summary: The purpose of this study is to determine the threshold for iodine quantification to distinguish between non-enhancing benign renal lesions and potential enhancing masses on portal venous dual-layer spectral computed tomography (CT), in order to reduce the need for additional multiphase CT. By analyzing the data, thresholds for non-enhancing lesions and enhancing masses were determined, which can help doctors make diagnoses and reduce unnecessary examinations.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenrui Jiang, Zhiping Han, Xing Tang, Hong Yin, Jian Zhang
Summary: The study shows that including DWI in the diagnostic algorithm for suspected PM can effectively identify malignancy and avoid unnecessary invasive procedures. DWI has some potential advantages in clinical application.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Subin Heo, Dong Wook Kim, Sang Hyun Choi, Seong Woo Kim, Jong Keon Jang
Summary: The liver surface nodularity (LSN) score demonstrated good diagnostic performance in assessing hepatic fibrosis stage. The sensitivity of the LSN score was highest in diagnosing advanced fibrosis (88%; 95% confidence interval [CI], 60-97%), and the specificity was highest in diagnosing significant fibrosis (89%; 95% CI, 83-93%). The diagnostic performance of the LSN score varied according to the cutoff value, imaging modality, and reference standard.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Hye Min, Seong Hyun Kim, Jeong Ah Hwang, Seung Hyup Hyun, Sang Yun Ha, Seo-Youn Choi, Seon Woo Kim, Hye Seung Kim
Summary: Both LI-RADS category on MRI and TLR on PET-CT are associated with the postoperative prognosis of PLCs. The prognosis of PLCs classified as LR-M can be further stratified according to the TLR group, but not for the PLCs classified as LR-4/5.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberto Cannella, Tyler J. Fraum, Daniel R. Ludwig, Amir A. Borhani, Allan Tsung, Alessandro Furlan, Kathryn J. Fowler
Summary: The study evaluated the potential of targetoid appearance on T2-weighted imaging and signs of tumor vascular involvement as new LI-RADS features for distinguishing HCC from other non-HCC PLCs. Targetoid appearance demonstrated high specificity for non-HCC PLCs, while features of tumor vascular involvement, especially vascular encasement and obliteration, showed high sensitivity for non-HCC PLCs. Inter-reader agreement was moderate to substantial.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Katarzyna Rutka, Adam Garkowski, Katarzyna Karaszewska, Urszula Lebkowska
Summary: Systemic sclerosis is a connective tissue disease characterized by fibrosis in skin and internal organs, vascular obliteration, and autoantibody production. Diagnostic imaging plays a crucial role in diagnosing and monitoring patients, with MRI and ultrasonography being important tools in the evaluation process.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guilherme Jaquet Ribeiro, Romain Gillet, Gabriela Hossu, Jean-Michel Trinh, Eve Euxibie, Francois Sirveaux, Alain Blum, Pedro Augusto Gondim Teixeira
Summary: This study proposed a systematic approach to evaluate the characteristics of solitary bone tumors, identifying multiple benign and malignant indicators using a multimodality approach. A Bone Tumor Imaging Reporting and Data System (BTI-RADS) was suggested for lesion stratification based on increasing malignancy frequency, showing fair reproducibility.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hong Zeng, Guangzi Shi, Siyao Mai, Haiqing Liu, Zhuo Wu
Summary: This study evaluated imaging and clinical features of colorectal liver metastases with macroscopic intrabiliary growth, finding a tendency for intraductal growth and high recurrence after surgical treatment. The characteristic imaging features of intrabiliary growth of liver metastasis aid in accurate diagnosis and treatment planning.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Ah Hwang, Sunyoung Lee, Ji Eun Lee, Jongjin Yoon, Seo-Yeon Choi, Jaeseung Shin
Summary: This study retrospectively investigated the relationship between preoperative clinical and imaging features and recurrence-free survival (RFS) in patients with iCCAs who underwent curative resection. The study found that the LI-RADS category may play a role in predicting RFS in high-risk patients. The results showed lower recurrence rates in patients categorized as LR-4 or 5.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Gastroenterology & Hepatology
Jaeseung Shin, Sunyoung Lee, Ja Kyung Yoon, Won Jeong Son, Yun Ho Roh, Yong Eun Chung, Jin-Young Choi, Mi-Suk Park
Summary: This study compared the performance of two imaging criteria for diagnosing hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI) with hepatobiliary agent (HBA). The results showed that the definite HCC category of the Korean Liver Cancer Association-National Cancer Center (KLCANCC) 2018 criteria had higher sensitivity and lower specificity compared to the LR-5 of the Liver Imaging Reporting and Data System (LI-RADS) v2018 for diagnosing HCC using MRI with HBA.
Review
Radiology, Nuclear Medicine & Medical Imaging
Sunyoung Lee, Yeun-Yoon Kim, Jaeseung Shin, Won Jeong Son, Yun Ho Roh, Jin-Young Choi, Claude B. Sirlin, Victoria Chernyak
Summary: The study aimed to estimate the percentages of hepatocellular carcinoma (HCC) and overall malignancy for each LI-RADS category using CT and MRI. The pooled percentages of HCC and overall malignancy did not differ between CT, MRI with extracellular contrast agents, and MRI with gadoxetate for any LI-RADS category.
Article
Gastroenterology & Hepatology
Jae Hyon Park, Young Nyun Park, Myeong-Jin Kim, Mi-Suk Park, Jin-Young Choi, Yong Eun Chung, Hyungjin Rhee
Summary: This retrospective study analyzed patients who underwent resection for hepatocellular carcinoma (HCC) between January 2014 and December 2019. The results showed a strong association between fatty liver disease and metabolic syndrome with steatotic and steatohepatitic HCCs.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Ja Kyung Yoon, Dai Hoon Han, Sunyoung Lee, Jin-Young Choi, Gi Hong Choi, Do Young Kim, Myeong-Jin Kim
Summary: The study aimed to evaluate the per-lesion sensitivity and specificity of the KLCA-NCC 2022 criteria for the noninvasive diagnosis of HCC, and compared the diagnostic performance of ECA-MRI and HBA-MRI. The results showed that HBA-MRI had higher sensitivity in the definite HCC category compared to ECA-MRI, without compromising specificity. There were no significant differences in the sensitivity and specificity of probable or definite HCC categories between ECA-MRI and HBA-MRI.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Genetics & Heredity
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
Summary: LOXL2 plays a significant role in drug resistance and EMT regulation in pancreatic cancer, and its inhibition reduces cancer stemness by regulating MAPK signaling activity. The activation of glucose metabolism and regulation of NF-kappa B signaling contribute to LOXL2 induction and cancer progression in gemcitabine-resistant pancreatic cancer.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cheng William Hong, Victoria Chernyak, Jin-Young Choi, Sonia Lee, Chetan Potu, Timoteo Delgado, Tanya Wolfson, Anthony Gamst, Jason Birnbaum, Rony Kampalath, Chandana Lall, James T. Lee, Joseph W. Owen, Diego A. Aguirre, Mishal Mendiratta-Lala, Matthew S. Davenport, William Masch, Alexandra Roudenko, Sara C. Lewis, Andrea Siobhan Kierans, Elizabeth M. Hecht, Mustafa R. Bashir, Giuseppe Brancatelli, Michael L. Douek, Michael A. Ohliger, An Tang, Milena Cerny, Alice Fung, Eduardo A. Costa, Michael T. Corwin, John P. McGahan, Bobby Kalb, Khaled M. Elsayes, Venkateswar R. Surabhi, Katherine Blair, Robert M. Marks, Natally Horvat, Shaun Best, Ryan Ash, Karthik Ganesan, Christopher R. Kagay, Avinash Kambadakone, Jin Wang, Irene Cruite, Bijan Bijan, Mark Goodwin, Guilherme Moura Cunha, Dorathy Tamayo-Murillo, Kathryn J. Fowler, Claude B. Sirlin
Summary: The study aims to assess reader agreement of LI-RADS in an international multicenter multireader setting using scrollable images. The results showed moderate agreement for LI-RADS version 2018 overall, and the agreement between research readers was higher than that between research and clinical readers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Seo-Bum Cho, Jae Seung Lee, Hye Won Lee, Jin-Young Choi, Seung Up Kim
Summary: This study evaluated the quality of surveillance ultrasound (US) for hepatocellular carcinoma (HCC) utilizing fusion imaging and found that conventional US may underestimate the limitations of the sonic window.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sunyoung Lee, Yeun-Yoon Kim, Jaeseung Shin, Yun Ho Roh, Jin-Young Choi, Victoria Chernyak, Claude B. Sirlin
Summary: The study performed an updated meta-analysis to evaluate the diagnostic performance of LI-RADS v2018 LR-5 for hepatocellular carcinoma (HCC) and compare the differences among imaging modalities and type of MRI contrast material. The results showed that LI-RADS v2018 LR-5 provides high specificity for HCC diagnosis regardless of modality or contrast material, while ECA-MRI showed higher sensitivity than CT or Gx-MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nieun Seo, Dong Jin Joo, Mi-Suk Park, Seung-seob Kim, Hye Jung Shin, Yong Eun Chung, Jin-Young Choi, Myoung Soo Kim, Myeong-Jin Kim
Summary: The study aimed to investigate the optimal radiologic method for determining Milan criteria (MC) in predicting post-liver transplantation (LT) recurrence in hepatocellular carcinoma (HCC) patients. The findings showed that MRI with mRECIST was the optimal method in predicting recurrence, with higher accuracy and sensitivity compared to CT with LI-RADS TRA or MRI with mRECIST.
EUROPEAN RADIOLOGY
(2023)