Article
Chemistry, Medicinal
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang
Summary: The study demonstrates that physcion protects neuronal cells against I/R injury by inhibiting the TLR4/NF-kB pathway, reducing inflammatory response and oxidative stress, and decreasing apoptosis, suggesting a promising therapeutic candidate for ischemic stroke.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Environmental Sciences
Emad H. M. Hassanein, Heba F. Khader, Rasha A. Elmansy, Hanan S. Seleem, Mohamed Elfiky, Zuhair M. Mohammedsaleh, Fares E. M. Ali, Tarek Hamdy Abd-Elhamid
Summary: This study demonstrated the protective role of umbelliferone against ischemia/reperfusion injury in the liver, with a mechanism involving activation of the Keap-1/Nrf-2/ARE signaling pathway and suppression of the TLR4/NF-kappa B-p65 signaling pathway. Umbelliferone effectively reduced oxidative stress, activated antioxidant enzymes, and modulated inflammatory responses to ameliorate liver injury caused by IR.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Lin Li, Shaoqian Yue, Rui Han, Yajun Yu, Peng Zhang, Ling Lv, Jinqiang Zhu, Min Zhou, Xiang Fan, Han Zhang
Summary: This study aimed to investigate the neuroprotective effects and underlying mechanisms of storax on oxygen-glucose deprivation/reoxygenation (OGD/R) in injured cortical neurons. The results showed that storax protected primary cortical neurons by suppressing ROS generation and cell apoptosis, alleviating inflammatory cytokines expression, and inhibiting the TLR4/TRAF6/NF-kappa B signaling pathway.
Article
Medicine, Research & Experimental
Mahmoud M. Samaha, Omnia A. Nour, Haitham M. Sewilam, Dalia H. El-Kashef
Summary: This study investigated the potential beneficial effects of Diacerin on adenine-induced CKD in rats. The results showed that Diacerin effectively ameliorated renal damage and attenuated oxidative stress caused by adenine.
Article
Medicine, Research & Experimental
Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair, Walaa Yehia Abdelzaher
Summary: Telmisartan demonstrates protective effects against hepatic I/R injury in rats by modulating oxidative stress parameters, myeloperoxidase levels, PPARγ and TLR4 mRNA expression, as well as NF-κB and caspase-3 immunoexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Sachiko Watanabe, Kosuke Zenke, Masashi Muroi
Summary: In this study, a novel function of lipoteichoic acid (LTA) was discovered, which involves suppression of TLR4-mediated signaling independently of TLR2 under serum-free conditions. LTA promotes the association of MD-2 molecules to form an inactive TLR4/MD-2 complex dimer, thereby preventing TLR4-mediated signaling.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Plant Sciences
Hai-Dong Chen, Ming-Zhao Jiang, Ying-Ying Zhao, Xin Li, Hai Lan, Wan-Qi Yang, Yong Lai
Summary: This study discussed the protective effect of Erigeron breviscapus extract (breviscapine) on cerebral ischemia and its possible mechanism by targeting intestinal flora, brain inflammatory pathway, and intestinal CYP3A4. The results indicated that breviscapine could protect rats from cerebral ischemia-reperfusion injury by regulating intestinal flora, inhibiting brain TLR4/MyD88/NF-.B inflammatory pathway, and intestinal CYP3A4 expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Summary: Sevoflurane postconditioning exerts hepatoprotective effects by inhibiting apoptosis, oxidative stress, and inflammatory response, improving survival rates in HIRI mice. Regulation of miR-142 and HMGB1 expression, as well as blocking the TLR4/NF-kappa B pathway activation, contribute to the protective effects of sevoflurane in hepatic I/R injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zijun Zhao, Yishuai Li, Fei Chi, Li Ma, Yanan Li, Zhiyong Hou, Qiujun Wang
Summary: In this study, we investigated the protective effect of sevoflurane postconditioning against cerebral ischemia reperfusion (I/R) injury and its potential mechanism. The results showed that sevoflurane postconditioning ameliorated neurological deficits induced by cerebral I/R and suppressed neuroinflammatory responses by inhibiting the TLR4/MyD88/TRAF6 signaling pathway.
Article
Integrative & Complementary Medicine
Yuting Cui, Fangyuan Zhang, Weiming Xu, Ziyun Li, Jiaxi Zou, Ping Gao, Jingqing Hu
Summary: This study found that Si-Miao-Yong-An decoction can improve coronary artery disease by reducing inflammation and regulating gut microbiota. Si-Miao-Yong-An was found to enhance cardiac function, decrease inflammatory factors, and modify the composition of gut microbiota. The results suggest that Si-Miao-Yong-An holds promise as a therapeutic agent for the management of CAD.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Surgery
Jing Yang, Youping Wu, Yan Xu, Ji Jia, Wenbin Xi, Hui Deng, Weifeng Tu
Summary: Dexmedetomidine (DEX) exerts protective effects against intestinal ischemia/reperfusion (I/R) injury in rats and OGD/R-induced damage in Caco-2 cells, possibly through its anti-inflammatory properties and inhibition of the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cell Biology
Ji Young Kim, Ji Hye Shin, Mi-Jeong Kim, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee
Summary: beta-arrestin 2 (ARRB2) is shown to have a negative regulatory role in lung cancer progression by inhibiting TLR3 and TLR4-induced autophagy. The decrease in ARRB2 expression is correlated with enrichment gene sets associated with oncogenic and cancer genes. ARRB2 interacts with TRAF6 and BECN1 to inhibit NF-κB activation and autophagy induced by TLR3 and TLR4. Knockout of ARRB2 enhances cancer migration, invasion, colony formation, and proliferation in response to TLR3 and TLR4 stimulation.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mohamed A. Morsy, Yasmine F. Ibrahim, Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Seham A. Abdel-Gaber
Summary: Paeonol can protect against hepatic ischemia/reperfusion injury by inhibiting oxidative stress, inflammation, and apoptosis.
Article
Cell & Tissue Engineering
Tomoya Muto, Maria Guillamot, Jennifer Yeung, Jing Fang, Joshua Bennett, Bettina Nadorp, Audrey Lasry, Luna Zea Redondo, Kwangmin Choi, Yixiao Gong, Callum S. Walker, Kathleen Hueneman, Lyndsey C. Bolanos, Laura Barreyro, Lynn H. Lee, Kenneth D. Greis, Nikita Vasyliev, Alireza Khodadadi-Jamayran, Evgeny Nudler, Amaia Lujambio, Scott W. Lowe, Iannis Aifantis, Daniel T. Starczynowski
Summary: Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of pre-leukemic cells that acquire specific mutations. TRAF6, a ubiquitin ligase gene, is identified to cooperate with pre-leukemic cells and its loss leads to overt myeloid leukemia through MYC-dependent stem cell signatures. Repression of TRAF6 signaling can potentially contribute to the development of acute leukemia.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.