Article
Biochemistry & Molecular Biology
Suping Ren, Yiying Bian, Yongyong Hou, Zhendi Wang, Zhuo Zuo, Zhiyuan Liu, Yue Teng, Jingqi Fu, Huihui Wang, Yuanyuan Xu, Qiang Zhang, Yanyan Chen, Jingbo Pi
Summary: Adipocytes play crucial roles in maintaining energy balance, where NFE2L1 is identified as a key regulator in adipocyte development and function. While the long isoforms of NFE2L1 are known for their involvement in antioxidant response and proteasome homeostasis, the tissue distribution and physiological function of NFE2L1 isoforms, especially the short isoforms, are still under investigation.
Article
Biology
Muhammad Hamza Bokhari, Carina Halleskog, Alice Aslund, Nathalie Boulet, Eva Casadesus Rendos, Jasper Martin Anton de Jong, Robert Csikasz, Ez-Zoubir Amri, Irina Shabalina, Tore Bengtsson
Summary: The study demonstrates the crucial role of UCP1 protein in the thermogenesis of murine brown and brite adipocytes. The use of isothermal microcalorimetry is established as a sensitive and accurate technique for measuring this heat-producing response.
COMMUNICATIONS BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yasuhiro Onogi, Siegfried Ussar
Summary: Brown adipose tissue (BAT) is a tightly controlled regulator of body temperature and nutrient balance, influenced by complex hormonal and nervous inputs. This article provides an overview of key regulatory circuits, including diurnal rhythms and the interdependency of nutrient utilization in thermogenesis. It also discusses additional factors mediating sympathetic BAT activation and limitations of glucose-based BAT activity measurements.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Cell Biology
Jennifer L. Cotton, Kyvan Dang, Lu Hu, Yang Sun, Alka Singh, Mihir S. Rajurkar, Qi Li, Xu Wu, Junhao Mao
Summary: PTEN and LKB1 deficiency in Gli1-expressing gut mesenchymal cells, but not intestinal epithelium, drives polyp formation resembling human polyposis. Additionally, the study reveals the differential roles of PTEN and LKB1 in regulating the mTOR signaling pathway.
Article
Multidisciplinary Sciences
Max Friesen, Andrew S. Khalil, M. Inmaculada Barrasa, Jacob F. Jeppesen, David J. Mooney, Rudolf Jaenisch
Summary: This study developed a protocol using human pluripotent stem cell-derived adipocytes that can produce a potent insulin response comparable to in vivo adipocytes under physiological nutrient conditions. This method provides a novel platform for studying insulin signaling and resistance.
Article
Nutrition & Dietetics
Lichun Qiao, Ziwei Guo, Haobiao Liu, Jiaxin Liu, Xue Lin, Huan Deng, Xuan Liu, Yan Zhao, Xiang Xiao, Jian Lei, Jing Han
Summary: This study reveals the mechanisms underlying liver fibrosis induced by selenium deficiency and the preventive effects of nano-selenium supplementation on liver fibrosis. It demonstrates the crucial roles of mitochondrial energy metabolism and mitophagy in these processes.
Article
Agriculture, Dairy & Animal Science
Jiaqi Liu, Jie Li, Wentao Chen, Xintao Xie, Xingang Chu, Teresa G. Valencak, Yizhen Wang, Tizhong Shan
Summary: The study revealed that porcine CRTC3 expression is associated with fat deposition in vivo, and overexpression of CRTC3 leads to increased lipid accumulation and gene expression related to mature adipocytes. Metabolomic analysis showed significant changes in lipid, amino acid, and nucleotide metabolites in adipocytes with CRTC3 overexpression, while RNA-seq analysis indicated alterations in genes and pathways involved in adipogenesis, fatty acid metabolism, and glycerophospholipid metabolism. These findings suggest that CRTC3 plays a regulatory role in lipid metabolism and influences lipid accumulation in porcine subcutaneous adipocytes.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Summary: White adipocyte metabolism plays a crucial role in systemic metabolism regulation and is often disrupted in conditions like cancer and type 2 diabetes mellitus. This review provides an overview of lipid metabolism in white adipocytes and discusses how these pathways can serve as therapeutic targets in metabolic disorders.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Cell Biology
Gang Wei, Honglin Sun, Kai Dong, Libing Hu, Qi Wang, Qian Zhuang, Yan Zhu, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang, Junli Liu
Summary: Clear cell renal cell carcinoma preferentially invades perinephric adipose tissue (PAT), with a bi-directional communication between ccRCC cells and PAT described in this study. The secretion of PTHrP by ccRCC cells promotes PAT browning, while PAT-mediated thermogenesis enhances ccRCC growth and metastasis. Tyrosine kinase inhibitors (TKIs) used in ccRCC treatment can exacerbate this vicious cycle, but pharmacological suppression of adipocyte browning can enhance the anti-tumor efficacy of TKI sunitinib.
Article
Multidisciplinary Sciences
Na Chen, Mingyang Yuan, NingNing Zhang, Maopei Chen, Ruixin Liu, Jiqiu Wang, Peng Lu
Summary: The study showed that knocking out the Ctnnb1 gene in UCP1-positive adipocytes led to increased browning of white adipose tissue and increased energy expenditure in mice. It was also found that 0-catenin inhibited thermogenic gene expression and Ucp1 expression in differentiated beige adipocytes at the transcription level.
Article
Multidisciplinary Sciences
Vera J. M. Nies, Dicky Struik, Sihao Liu, Weilin Liu, Janine K. Kruit, Michael Downes, Tim van Zutphen, Henkjan J. Verkade, Ronald M. Evans, Johan W. Jonker
Summary: This study found that FGF1 can increase glucose uptake in adipocytes by activating GLUT4 protein. Furthermore, prolonged exposure to FGF1 can stimulate adipocyte glucose uptake by transcription of GLUT1 protein.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Na Chen, Mingyang Yuan, NingNing Zhang, Maopei Chen, Ruixin Liu, Jiqiu Wang, Peng Lu
Summary: Canonical WNT pathway exacerbates obesity in mature adipocytes. Knockout of Ctnnb1 in UCP1-positive adipocytes led to increased browning of white adipose tissue (WAT) and enhanced energy expenditure in mice. Beta-catenin repressed thermogenic genes expression in beige adipocytes and Ucp1 expression at the transcription level.
Article
Environmental Sciences
Zhongmin Sui, Chaoqing Wei, Xuan Wang, Huihui Zhou, Chengdong Liu, Kangsen Mai, Gen He
Summary: Ammonia has significant impacts on the growth and health of crustaceans, leading to oxidative stress and metabolic disorders. However, little is known about its effects on nutrient metabolism and signaling pathways. This study provides important insights into the metabolic responses and nutrient signaling under ammonia stress, enhancing our understanding of the physiological responses and growth performance in shrimp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Lisa Christen, Helen Broghammer, Inka Rapoehn, Kevin Moehlis, Christian Strehlau, Aleix Ribas-Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Koerner, Kerstin Rohde-Zimmermann, Anne Hoffmann, Nora Kloeting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen-Cotta, Michael Stumvoll, Matthias Blueher, John T. Heiker, Juliane Weiner
Summary: This study demonstrates the functional relevance of myoglobin (MB) in brown adipose tissue (BAT), showing that MB controls mitochondrial function and thermogenesis in brown and beige adipocytes. MB not only facilitates oxygen storage and flux to the mitochondria, but also regulates the acute response of BAT to adrenergic stimulation, signaling, and lipolysis. The overexpression of MB in white adipocytes also increases their metabolic activity. These findings provide valuable insights into the mechanisms of thermogenesis in BAT and potential therapeutic approaches for obesity and related diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tomas Venit, Oscar Sapkota, Wael Said Abdrabou, Palanikumar Loganathan, Renu Pasricha, Syed Raza Mahmood, Nadine Hosny El Said, Shimaa Sherif, Sneha Thomas, Salah Abdelrazig, Shady Amin, Davide Bedognetti, Youssef Idaghdour, Mazin Magzoub, Piergiorgio Percipalle
Summary: Metabolic reprogramming is a hallmark of tumorigenesis. In this study, the researchers found that nuclear myosin 1 regulates mitochondrial oxidative phosphorylation through the TFAM and PGC1 alpha transcription factors, and suggest that its depletion contributes to the Warburg effect during tumorigenesis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.