Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 27, Pages 11717-11733Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b13402
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Funding
- Dartmouth College, from Walter and Constance Burke Research Initiation Award
- National Science Foundation EPSCoR award [1757371]
- Army Research Office Young Investigator Program [W911NF-17-1-0398]
- Sloan Research Fellowship [26019]
- Cottrell Scholar Award [26019]
- 3M Non-Tenured Faculty Award
- James O. Freedman Presidential Scholars Program at Dartmouth College
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This paper describes the first implementation of an array of two-dimensional (2D) layered conductive metal-organic frameworks (MOFs) as drop-tasted film electrodes that facilitate voltammetric detection of redox active neurochemicals in a multianalyte solution. The device configuration comprises a glassy carbon electrode modified with a film of conductive MOF (M3HXTP2; M = Ni, Cu; and X = NH, 2,3,6,7,10,11-hexaiminotriphenylene (HITP) or 0, 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP)). The utility of 2D MOFs in voltammetric sensing is measured by the detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), and serotonin (5-HT) in 0.1 M PBS (pH = 7.4). In particular, Ni3HHTP2 MOFs demonstrated nanomolar detection limits of 63 +/- 11 nM for DA and 40 +/- 17 nM for 5-HT through a wide concentration range (40 nM-200 mu M). The applicability in biologically relevant detection was further demonstrated in simulated urine using Ni3HHTP2 MOFs for the detection of 5-HT with a nanomolar detection limit of 63 +/- 11 nM for 5-HT through a wide concentration range (63 nM-200 mu M) in the presence of a constant background of DA. The implementation of conductive MOFs in voltammetric detection holds promise for further development of highly modular, sensitive, selective, and stable electroanalytical devices.
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