Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Shui Tian, Qiang Wang, Siqi Zhang, Zhilu Chen, Zhongpeng Dai, Wei Zhang, Zhijian Yao, Qing Lu
Summary: This study used magnetoencephalography (MEG) to explore the neuro-electrophysiological features of major depressive disorder (MDD) at baseline and predicted their early antidepressant response. The results showed that patients with early response (ER) exhibited increased functional couplings across brain regions after treatment, which were significantly correlated with severity of depressive symptoms. The study highlighted the identification ability of large-scale couplings biomarkers in early antidepressant response prediction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Robert Gyorgy Vida, Eszter Saghy, Richard Bella, Sandor Kovacs, Dalma Erdosi, Judit Jozwiak-Hagymasy, Antal Zemplenyi, Tamas Tenyi, Peter Osvath, Viktor Voros
Summary: A systematic literature review found that unilateral High-Frequency Left-sided (HFL) repetitive Transcranial Magnetic Stimulation (rTMS) was more effective than sham rTMS in treating Treatment-Resistant Depression (TRD). rTMS may be beneficial as an adjunctive treatment in patients with Major Depressive Disorder (MDD) after two treatment failures.
Article
Neurosciences
Tiffany C. Ho, Boris Gutman, Elena Pozzi, Hans J. Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J. Veltman, Knut Schnell, Ilya Veer, Henrik Walter, Ian H. Gotlib, Matthew D. Sacchet, Andre Aleman, Nynke A. Groenewold, Dan J. Stein, Meng Li, Martin Walter, Christopher R. K. Ching, Neda Jahanshad, Anjanibhargavi Ragothaman, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Philipp G. Saemann, Lianne Schmaal
Summary: This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Multidisciplinary
Sijia Liu, Ruihua Ma, Yang Luo, Panqi Liu, Ke Zhao, Hua Guo, Jing Shi, Fude Yang, Yunlong Tan, Shuping Tan, Zhiren Wang
Summary: The study found lower accuracy in facial expression recognition in patients with MDD compared to healthy controls, with differences in facial expression recognition. The reaction time for facial expression recognition was significantly longer in MDD patients, and abnormalities were found in some brain regions during resting state. Changes in ReHo values may represent abnormal patterns of spontaneous brain activity in neural circuits related to emotion perception.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pawel Mocko, Katarzyna Sladowska, Pawel Kawalec, Yana Babii, Andrzej Pilc
Summary: Major depressive disorder is a severe mental disorder that can lead to suicide if left untreated. Scopolamine is being explored as a potential therapeutic option for depression, with varying levels of antidepressant effects observed in studies. Further large randomized controlled trials are needed to confirm the effectiveness and safety of scopolamine in treating depression, particularly through different routes of administration.
Article
Psychiatry
Caroline B. B. C. M. Heuschen, Roel J. T. Mocking, Jasper B. Zantvoord, Caroline A. Figueroa, Aart H. Schene, Damiaan A. J. P. Denys, Henricus G. Ruhe, Claudi L. H. Bockting, Anja Lok
Summary: This study demonstrates that self-reported suicidal symptoms persist during remission in rrMDD and predict recurrence, independent of residual symptoms. Monitoring both suicidal and depressive symptomatology during remission in rrMDD, preferably using self-reported questionnaires, is recommended for future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Or Duek, Rebecca Seidemann, Robert H. Pietrzak, Ilan Harpaz-Rotem
Summary: Emotional numbing symptoms are not simply a manifestation of major depressive disorder, but a unique feature of PTSD. These findings suggest that emotional numbing should be addressed within the context of trauma as a distinct aspect of PTSD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Ying Li, Peidong Miao, Fang Li, Jinsong Huang, Lijun Fan, Qiaoling Chen, Yunan Zhang, Feng Yan, Yan Gao
Summary: This study investigates the relationship between clock genes and Major Depressive Disorder (MDD). The researchers identified six clock genes that are closely related to MDD and established a diagnostic model for depression using these genes. The pathways associated with these clock genes were mainly involved in circadian rhythm, TGF-beta signaling, and adipocytokine signaling. The study also revealed correlations between immune cells and clock genes, as well as potential therapeutic drugs for MDD. The findings provide valuable insights for understanding the pathogenesis of MDD and potential targets for treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Hossein Malekizadeh, Omid Saed, Alireza Rashtbari, Mozhdeh Sajjadi, Davoud Ahmadi, Eivind Haga Ronold
Summary: This study compares deficits in executive function (EF) among hospitalized, outpatient, and subclinical depressed patients, as well as a healthy control group. The results highlight the impact of depression severity on EF deficits, with more severe depressive symptoms associated with greater deficits in EF.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Zhifang Deng, Jue Liu, Shen He, Wenqi Gao
Summary: This study identifies the role of pyroptosis in major depressive disorder (MDD) and develops a novel diagnostic model based on pyroptosis-related genes. The study also finds two distinct pyroptosis subtypes in MDD cases, which have different immune and biological characteristics.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Joan Winter, Kimberly Curtis, Bo Hu, Anita H. Clayton
Summary: Sexual dysfunction is a common symptom in approximately 70% of patients with major depressive disorder. Antidepressant medications and adjunctive treatments can contribute to sexual dysfunction, making evaluation and treatment complex.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Clinical Neurology
Nathaniel A. Shanok, Santiago Rodriguez, Sabrina Muzac, Carla Huertas Del Pino, Leah Brown, Raul Rodriguez
Summary: This study investigated the neurophysiological changes resulting from Deep TMS treatment for depression using resting-state quantitative electroencephalography (QEEG) measures. The results showed a reduction in slow-frequency brain activity in the prefrontal cortex following treatment, and baseline QEEG measures accurately predicted treatment response. These findings suggest that TMS improves depressive symptoms by modulating slow-wave brain activity in the prefrontal cortex.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Nethi Walia, Ajeet Sidana, Priti Arun, Gurjit Kaur, Vishal Sharma
Summary: The study found that telomerase activity was higher in drug-naive patients with major depressive disorder (MDD) compared to healthy controls, and it was significantly correlated with the severity of depression. Non-responders had significantly higher telomerase activity compared to responders, indicating telomerase activity as a potential biomarker in the underlying biological mechanism of MDD and response to antidepressant pharmacotherapy.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Kevin P. Hill, Mark S. Gold, Charles B. Nemeroff, William McDonald, Adrienne Grzenda, Alik S. Widge, Carolyn Rodriguez, Nina Kraguljac, John H. Krystal, Linda L. Carpenter
Summary: This review aims to outline the evidence for the therapeutic use of cannabinoids for specific medical conditions and the potential side effects associated with acute and chronic cannabis use. The results show that there are currently no approved psychiatric indications for cannabinoids, and the evidence supporting their use in the treatment of psychiatric disorders is limited. The strongest evidence for cannabinoid prescription is for the management of pain and spasticity.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Charles B. Nemero
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
S. J. Sharp, M. A. Bond, K. S. Chiang, S. J. Collier, J. Farrington, T. Lanza di Scalea, C. B. Nemeroff, D. J. Newport, D. A. Spelber, S. M. Strakowski, J. R. C. Almeida
Summary: The study validated a significant positive correlation between the depression subscale of ASRS and PHQ-9 and QIDS-16, establishing meaningful clinical thresholds for depression assessment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Luca Sforzini, Courtney Worrell, Melisa Kose, Ian M. Anderson, Bruno Aouizerate, Volker Arolt, Michael Bauer, Bernhard T. Baune, Pierre Blier, Anthony J. Cleare, Philip J. Cowen, Timothy G. Dinan, Andrea Fagiolini, I. Nicol Ferrier, Ulrich Hegerl, Andrew D. Krystal, Marion Leboyer, R. Hamish McAllister-Williams, Roger S. McIntyre, Andreas Meyer-Lindenberg, Andrew H. Miller, Charles B. Nemeroff, Claus Normann, David Nutt, Stefano Pallanti, Luca Pani, Brenda W. J. H. Penninx, Alan F. Schatzberg, Richard C. Shelton, Lakshmi N. Yatham, Allan H. Young, Roland Zahn, Georgios Aislaitner, Florence Butlen-Ducuing, Christine Fletcher, Marion Haberkamp, Thomas Laughren, Fanni-Laura Mantyla, Koen Schruers, Andrew Thomson, Gara Arteaga-Henriquez, Francesco Benedetti, Lucinda Cash-Gibson, Woo Ri Chae, Heidi De Smedt, Stefan M. Gold, Witte J. G. Hoogendijk, Valeria Jordan Mondragon, Eduard Maron, Jadwiga Martynowicz, Elisa Melloni, Christian Otte, Gabriela Perez-Fuentes, Sara Poletti, Mark E. Schmidt, Edwin van de Ketterij, Katherine Woo, Yanina Flossbach, J. Antoni Ramos-Quiroga, Adam J. Savitz, Carmine M. Pariante
Summary: The document discusses the criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) which are not clearly defined, using a Delphi-method-based consensus approach. It reviews literature and gathers international experts to evaluate controversies and provide recommendations on designing clinical trials and guiding research. It aims to support the design of a protocol for platform trials of new medications for TRD/PRD as part of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Martin H. Teicher, Jeoffry B. Gordon, Charles B. Nemeroff
Summary: Childhood maltreatment is the most important preventable risk factor for psychiatric disorders. Those who have been maltreated tend to develop psychiatric disorders earlier, have more severe symptoms, more comorbidities, and respond less favorably to treatment compared to non-maltreated individuals. Additionally, maltreated individuals show distinct alterations in stress-susceptible brain regions, hormonal responses, and inflammatory markers, highlighting the need for a more nuanced approach to diagnosis and treatment in psychiatric disorders.
MOLECULAR PSYCHIATRY
(2022)
Review
Psychiatry
Mara Parellada, Alvaro Andreu-Bernabeu, Monica Burdeus, Antonia San Jose Caceres, Elena Urbiola, Linda L. Carpenter, Nina V. Kraguljac, William M. McDonald, Charles B. Nemeroff, Carolyn I. Rodriguez, Alik S. Widge, Matthew W. State, Stephan J. Sanders
Summary: The aim of this study was to evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms. A systematic review was conducted and 280 articles were included, reporting on 940 biomarkers. However, the studies showed high heterogeneity and there is currently no sufficient evidence for response biomarkers in ASD clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Justin K. Rajendra, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: This study aimed to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. The results showed that remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or combining these treatment approaches.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Biographical-Item
Neurosciences
Charles B. B. Nemeroff
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Psychology, Clinical
Kevin M. Crombie, Tom G. Adams, Joseph E. Dunsmoor, Benjamin N. Greenwood, Jasper A. Smits, Charles B. Nemeroff, Josh M. Cisler
Summary: Posttraumatic stress disorder (PTSD) is often accompanied by heightened emotional responses, avoidance of trauma-related triggers, and physical health concerns. Traditional therapies focus on reducing anxiety symptoms, but do not address the physical health issues associated with PTSD. Recent evidence suggests that timed aerobic exercise can enhance fear extinction learning, making it a promising adjunctive strategy to improve physical health and enhance the effects of exposure therapies. This review provides an overview of relevant studies, discusses mechanisms behind enhanced fear extinction, and suggests areas for future research to further explore the importance of incorporating exercise into PTSD treatment.
JOURNAL OF ANXIETY DISORDERS
(2023)
Review
Psychiatry
Alik S. Widge, Ayana Jordan, Nina V. Kraguljac, Christi R. P. Sullivan, Saydra Wilson, Tami D. Benton, Jonathan E. Alpert, Linda L. Carpenter, John H. Krystal, Charles B. Nemeroff, Kafui Dzirasa
Summary: Investigators from minoritized backgrounds are underrepresented in psychiatric research, leading to disparities in mental health care. This underrepresentation is a result of the interlocking effects of structural biases, such as limited access to advanced training and opportunities, stereotype threats and microaggressions, isolation, limited funding, and unique financial pressures. Structural racism, which perpetuates race-based disparities, exists despite efforts to increase diversity. Potential approaches to address these biases include undergraduate research experiences, financial support for training programs, targeted mentoring, better use of diversity funding, scientific reentry support, diversity efforts in leadership, and examination of hiring and promotion practices. Implementing these approaches alongside outcome measurement has the potential to reverse decades of structural bias in psychiatry and psychiatric research.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Jeffrey D. Shahidullah, James Custer, Oscar Widales-Benitez, Nazan Aksan, Carly Hatchell, Jeffrey Newport, Karen Dineen Wagner, Eric A. Storch, Cynthia Claassen, Amy Garrett, Irma T. Ugalde, Wade Weber, Charles B. Nemeroff, Paul J. Rathouz
Summary: This study aims to describe the rater training protocol for administering semi-structured psychiatric interviews in large, multi-site studies and evaluate its effectiveness. The training involved synchronous and asynchronous learning modules, and certification included critique of mock scale administration. The protocol resulted in strong interrater reliability across all measures.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Shaunna L. Clark, Cody G. Dodd, Leslie Taylor, Sunita Stewart, Nancy Yang, Jeffrey D. Shahidullah, Andrew G. Guzick, Robyn Richmond, Nazan Aksan, Paul J. Rathouz, Justin F. Rousseau, D. Jeffrey Newport, Karen Dineen Wagner, Charles B. Nemeroff
Summary: This study investigated the substance use patterns and co-occurring psychiatric disorders in trauma-exposed youth. Four primary patterns of substance use were identified, with different characteristics. The findings highlight the importance of universal assessments of trauma, substance misuse, and mental health symptoms in youth.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: Using neuroimaging data, researchers identified increased connectivity between the subcallosal cingulate cortex and the anterior insula, as well as decreased connectivity between the subcallosal cingulate cortex and the bilateral primary visual cortex and the insula and the bilateral caudate, as predictive factors for recurrence in major depressive disorder (MDD).
NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Neurosciences
Mark A. A. Frye, Charles B. B. Nemeroff
Summary: Pharmacogenomic technology is a developing field with broad application potential. Although previous studies did not show significant benefit, they laid the foundation for further research that should address limitations and include diverse populations. Future research needs to include large scale pharmacogenomic trials with GWAS analytics and explore optimal EHR user interface design.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Roger S. Mcintyre, Mohammad Alsuwaidan, Bernhard T. Baune, Michael Berk, Koen Demyttenaere, Joseph F. Goldberg, Philip Gorwood, Roger Ho, Siegfried Kasper, Sidney H. Kennedy, Josefina Ly-Uson, Rodrigo B. Mansur, R. Hamish McAllister-Williams, James W. Murrough, Charles B. Nemeroff, Andrew A. Nierenberg, Joshua D. Rosenblat, Gerard Sanacora, Alan F. Schatzberg, Richard Shelton, Stephen M. Stahl, Madhukar H. Trivedi, Eduard Vieta, Maj Vinberg, Nolan Williams, Allan H. Young, Mario Maj
Summary: Treatment-resistant depression is common and has serious public health implications. The lack of a consensus definition hampers accurate estimates of its prevalence and efforts to identify effective interventions, leading to heterogeneity in treatment decision-making and potentially compromising quality of care.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)