Article
Cardiac & Cardiovascular Systems
Elad Shemesh, Parag Anilkumar Chevli, Tareq Islam, Charles A. German, James Otvos, Joseph Yeboah, Fatima Rodriguez, Christopher deFilippi, Joao A. C. Lima, Michael Blaha, Ambarish Pandey, Muthiah Vaduganathan, Michael D. Shapiro
Summary: This study aimed to examine the association between ketone bodies (KB) and cardiovascular outcomes and mortality. The findings suggest that elevated endogenous KB in a healthy population is associated with a higher rate of cardiovascular disease and mortality, and KB could serve as a potential biomarker for cardiovascular risk assessment.
EUROPEAN HEART JOURNAL
(2023)
Review
Endocrinology & Metabolism
Yu- Cai Ye, Shi-Fan Chai, Xin-Ru Li, Mei-Na Wu, Hong-Yan Cai, Zhao-Jun Wang
Summary: Alzheimer's disease (AD) lacks effective clinical treatments and is characterized by brain energy deficits. Intermittent fasting (IF), which improves brain energy impairments by promoting ketone metabolism, has therapeutic potential for AD.
METABOLIC BRAIN DISEASE
(2023)
Review
Neurosciences
Lizbeth Garcia-Velazquez, Lourdes Massieu
Summary: A growing body of evidence supports the beneficial effects of ketone bodies, specifically acetoacetate and beta-hydroxybutyrate (BHB), on various physiological processes and diseases. BHB, the most abundant ketone body in circulation, can covalently bind to proteins in lysine residues, resulting in a post-translational modification called beta-hydroxybutyrylation (Kbhb). Kbhb has been identified in various proteins involved in chromatin structure, DNA repair, transcription, and metabolism, and it may have implications for cell signaling and genome regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Materials Science, Characterization & Testing
Veronica Luque-Agudo, Juan Manuel Casares-Lopez, Maria Luisa Gonzalez-Martin, Amparo M. Gallardo-Moreno, Margarita Hierro-Oliva
Summary: This research aims to study the degradation of polylactic acid (PLA) in a close-to-reality environment and investigate the influence of glucose and ketone bodies on the degradation process and material properties.
Article
Medicine, General & Internal
Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen
Summary: This study uses triangulation of evidence from observational and Mendelian randomization studies to investigate the association and causation between ketone bodies and cognitive function. The results suggest that 3-beta-hydroxybutyrate (BOHBUT), the most abundant ketone metabolite, has a beneficial effect on cognitive performance and may delay cognitive impairment and reduce the risk of Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Ciara I. I. Makievskaya, Vasily A. A. Popkov, Nadezda V. V. Andrianova, Xinyu Liao, Dmitry B. B. Zorov, Egor Y. Y. Plotnikov
Summary: The ketogenic diet (KD) has been used for epilepsy treatment since the 1920s and is now being considered for preventing other diseases. Research has investigated the use of KD as a therapeutic approach for ischemic injuries, however, conflicting results have been observed. This review provides a systematic analysis of studies from 1980 to 2022 on the effects and mechanisms of KD and its mimetics on ischemia-reperfusion injury in various organs. The analysis reveals a high diversity in KD composition and treatment protocols, which may contribute to the contradictory effects observed in different studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Issei Tomita, Hiroaki Tsuruta, Mako Yasuda-Yamahara, Kosuke Yamahara, Shogo Kuwagata, Yuki Tanaka-Sasaki, Masami Chin-Kanasaki, Yukihiro Fujita, Eiichiro Nishi, Hideki Katagiri, Hiroshi Maegawa, Shinji Kume
Summary: Accumulating evidence suggests that ketone bodies have health benefits, especially for longevity. However, the role of endogenous ketogenesis in mammalian life span and the safety and efficacy of long-term exogenous ketone body supplementation remain unclear. This study shows that a deficiency in endogenous ketogenesis shortens life span in mice, and this can be prevented by daily ketone body supplementation. It is also found that the timing of ketone body supplementation has different effects on mortality rates in normal and aged mice. In conclusion, endogenous ketogenesis affects mammalian survival, and the administration method and health status are important factors in the effects of ketone body supplementation.
Review
Neurosciences
Dario Garcia-Rodriguez, Alfredo Gimenez-Cassina
Summary: Ketone bodies are metabolites that can replace glucose as the main fuel of the brain in glucose scarcity situations. Apart from being an alternative fuel, they also have effects on neuronal physiology and gene expression, regulating neuronal excitability and responding to oxidative stress. In addition, they can act as signaling molecules in brain cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jong-Min Moon, Rafael Del Cano, Chochanon Moonla, Kittiya Sakdaphetsiri, Tamoghna Saha, Leticia Francine Mendes, Lu Yin, An-Yi Chang, Sumeyye Seker, Joseph Wang
Summary: P-Hydroxybutyrate (HB) is a key physiological ketone body that plays an important role in human health and wellness. Researchers have developed a noninvasive, simple, and rapid touch-based sweat testing method to measure HB, which can track the dynamic changes in HB levels following the intake of ketone supplements.
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Juan Antonio Requena-Ibanez, Belen Picatoste, Brian Fardman, Kiyotake Ishikawa, Renata Mazurek, Michael Pieper, Samantha Sartori, Jorge Rodriguez-Capitan, Valentin Fuster, Juan J. Badimon
Summary: This study investigates the cardioprotective potential of empagliflozin and ketone bodies during acute myocardial infarction. Pretreatment with empagliflozin for one week reduces ischemia reperfusion injury, MI size, microvascular obstruction, and increases myocardial salvage, while preserving left ventricle systolic function and reducing apoptosis and oxidative stress. Intravenous infusion of BOHB during myocardial ischemia also induces cardioprotection.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Chemistry, Applied
Xinyu Du, Xinghao Qi, Kai Li, Xiaoyan Li, Hongjian Sun, Olaf Fuhr, Dieter Fenske
Summary: The novel silylene-supported iron hydride 1 was synthesized via C(sp(3))-H bond activation and exhibited excellent catalytic activity for hydrosilylation of aldehydes and ketones. It showed good tolerance and catalytic activity for substrates with different functional groups on the benzene ring, with both ketones and aldehydes being reduced in good to excellent yields under the same catalytic conditions. A possible catalytic mechanism was proposed based on experiments and literature reports.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Chemistry, Analytical
Rafael Del Cano, Tamoghna Saha, Chochanon Moonla, Ernesto De la Paz, Joseph Wang
Summary: The development of mobile and wearable sensing devices for continuous ketone detection has received great attention. This review discusses the importance of ketone bodies and the advances in decentralized ketone sensing strategies in biomedical and nutrition applications. Special attention is given to electrochemical sensing platforms for on-site and wearable detection of I3-hydroxybutyrate (BHB) and the challenges of extended on-body BHB monitoring. Future trends, opportunities, and challenges in frequent home self-testing and continuous monitoring of ketone bodies for personalized healthcare, nutrition, and wellness are discussed in connection to mobile and wearable devices coupled to artificial intelligence.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Marie-Sophie L. Y. de Koning, B. Daan Westenbrink, Solmaz Assa, Erwin Garcia, Margery A. Connelly, Dirk J. van Veldhuisen, Robin P. F. Dullaart, Erik Lipsic, Pim van der Harst
Summary: Circulating ketone bodies are increased in patients with ST-segment elevation myocardial infarction (STEMI). Higher ketone bodies at 24 hours post-reperfusion are associated with larger myocardial infarct size and lower left ventricular ejection fraction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nadia Bendridi, Anna Selmi, Aneta Balcerczyk, Luciano Pirola
Summary: This review discusses the impact of diet on inflammatory environment and chronic diseases, as well as the potential of a no-carbohydrate ketogenic diet as a solution. Research has shown that ketone bodies modulate inflammation and influence gene transcription. Additionally, epigenome and chromatin remodeling may also play a key role in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna I. Miller, David Diaz, Bo Lin, Patryk K. Krzesaj, Sarah Ustoyev, Alfred Shim, Eugene J. Fine, Ehsan Sarafraz-Yazdi, Matthew R. Pincus, Richard D. Feinman
Summary: Ketone bodies, including acetoacetate and beta-hydroxybutyrate, inhibit the proliferation of cancer cells. Sodium acetoacetate and lithium ion both block the growth of cancer cells without killing them. Ketone bodies and ketogenic diets can enhance the efficacy of chemotherapeutic agents in killing cancer cells.
Review
Peripheral Vascular Disease
James E. Sharman, Isabella Tan, George S. Stergiou, Carolina Lombardi, Francesca Saladini, Mark Butlin, Raj Padwal, Kei Asayama, Alberto Avolio, Tammy M. Brady, Alan Murray, Gianfranco Parati
Summary: Automated oscillometric blood pressure measuring devices have replaced manual auscultatory blood pressure measurement by mercury sphygmomanometers in clinical settings. These validated devices provide similar blood pressure values to manual measurement, making them the recommended standard for hypertension diagnosis and management globally.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Peripheral Vascular Disease
Dean S. Picone, Raj Padwal, George S. Stergiou, Jordana B. Cohen, Richard J. McManus, Siegfried Eckert, Kei Asayama, Neil Atkins, Michael Rakotz, Cintia Lombardi, Tammy M. Brady, James E. Sharman
Summary: Clinically validated, automated arm-cuff blood pressure measuring devices are recommended for accurate measurement. However, most devices available for consumers lack proper validation, which increases the risk of misdiagnosis and mismanagement of blood pressure. Validated device lists have been developed to address this issue, but there are still challenges to overcome.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Azusa Hara, Takuo Hirose, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo
Summary: This study investigated the association between ambulatory blood pressure and the risk of home hypertension in a normotensive population. The results showed that considering ambulatory blood pressure can improve the accuracy of the 10-year prediction model for home hypertension risk.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Peripheral Vascular Disease
Yu-Ling Yu, Wen-Yi Yang, Azusa Hara, Kei Asayama, Harry A. Roels, Tim S. Nawrot, Jan A. Staessen
Summary: Lead is an environmental hazard that requires global attention. Human lead exposure in the western world has decreased to levels comparable to preindustrial era, primarily from natural sources. To reassess the health risks associated with present-day lead exposure, a two-pronged approach was used. Population metrics on adverse health effects of lead exposure were critically evaluated, and the results of the Study for Promotion of Health in Recycling Lead were compared. This comprehensive review suggests that current understanding of public and occupational health risks related to lead exposure urgently needs updating due to significant decrease in exposure levels over the past 40 years.
HYPERTENSION RESEARCH
(2023)
Editorial Material
Peripheral Vascular Disease
Kei Asayama
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Chisa Matsumoto, Shigeru Shibata, Takuya Kishi, Satoshi Morimoto, Masaki Mogi, Koichi Yamamoto, Kazuo Kobayashi, Masami Tanaka, Kei Asayama, Eiichiro Yamamoto, Hironori Nakagami, Satoshi Hoshide, Masashi Mukoyama, Kazuomi Kario, Koichi Node, Hiromi Rakugi
Summary: COVID-19 can result in long-term symptoms, known as long COVID, which may have an impact on hypertension and cardiovascular diseases. This article summarizes the potential effects of long COVID on hypertension and related organs, and discusses the influence of age and sex on long COVID. Lastly, it explores areas of uncertainty and future directions for improved understanding and prognosis of clinical problems associated with COVID-19.
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Shigeru Shibata, Kazuo Kobayashi, Masami Tanaka, Kei Asayama, Eiichiro Yamamoto, Hironori Nakagami, Satoshi Hoshide, Takuya Kishi, Chisa Matsumoto, Masaki Mogi, Satoshi Morimoto, Koichi Yamamoto, Masashi Mukoyama, Kazuomi Kario, Koichi Node, Hiromi Rakugi
Summary: The number of reported COVID-19 cases worldwide has exceeded 620 million, impacting people's health and daily lives since December 2019. The pandemic has affected blood pressure control in hypertensive patients due to restricted medical care access, psychological distress, and lifestyle changes.
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Kei Asayama, Katarzyna Stolarz-Skrzypek, Wen-Yi Yang, Tine W. Hansen, Jana Brguljan-Hitij, Augustine N. Odili, Yan Li, Jan A. Staessen
Summary: The International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome conducted a meta-analysis which found that 24-hour and nighttime blood pressure levels are the best predictors of adverse health outcomes. They also established corresponding thresholds for home and ambulatory blood pressure. The study emphasized the importance of out-of-office blood pressure monitoring in tackling the hypertension pandemic.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Gianfranco Parati, Grzegorz Bilo, Anastasios Kollias, Martino Pengo, Juan Eugenio Ochoa, Paolo Castiglioni, George S. Stergiou, Giuseppe Mancia, Kei Asayama, Roland Asmar, Alberto Avolio, Enrico G. Caiani, Alejandro De La Sierra, Eamon Dolan, Andrea Grillo, Przemyslaw Guzik, Satoshi Hoshide, Geoffrey A. Head, Yutaka Imai, Eeva Juhanoja, Thomas Kahan, Kazuomi Kario, Vasilios Kotsis, Reinhold Kreutz, Konstantinos G. Kyriakoulis, Yan Li, Efstathios Manios, Anastasia S. Mihailidou, Pietro Amedeo Modesti, Stefano Omboni, Paolo Palatini, Alexandre Persu, Athanasios D. Protogerou, Francesca Saladini, Paolo Salvi, Pantelis Sarafidis, Camilla Torlasco, Franco Veglio, Charalambos Vlachopoulos, Yuqing Zhang
Summary: Blood pressure is not static, but fluctuates continuously due to environmental and behavioral factors. Increased blood pressure variability may indicate impaired cardiovascular regulation and is associated with increased mortality and disease incidence.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Michihiro Satoh, Tomoya Yoshida, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Takuo Hirose, Kyosuke Takabatake, Megumi Tsubota-Utsugi, Azusa Hara, Kyoko Nomura, Kei Asayama, Masahiro Kikuya, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo
Summary: The long-term reproducibility of the white-coat effect is limited in the general population without antihypertensive treatment, and the change in the white-coat effect is mainly caused by office blood pressure variation.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kei Asayama
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Narumi Eguchi, Kei Asayama, Tomohiro Katsuya, Yutaka Hatori, Masaaki Miyakawa, Mitsuhiko Noda
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kayo Godai, Mio Kubo, Mai Kabayama, Arisa Wada, Michiko Kido, Sumiyo Hashimoto, Makiko Higashi, Hiromi Hatanaka, Takeshi Kikuchi, Takayuki Dodo, Yasuharu Tabara, Kei Asayama, Takayoshi Ohkubo, Hiromi Rakugi, Kei Kamide
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Arisa Wada, Mai Kabayama, Kayo Godai, Michiko Kido, Sumiyo Hashimoto, Makiko Higashi, Hiromi Hatanaka, Takeshi Kikuchi, Takayuki Dodo, Kei Asayama, Takayoshi Ohkubo, Hiromi Rakugi, Yasuharu Tabara, Kei Kamide
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Megumi Tsubota-Utsugi, Michihiro Satoh, Jun Watanabe, Jun Takebayashi, Tomoyuki Oki, Yukako Tatsumi, Kei Asayama, Masahiro Kikuya, Takahisa Murakami, Takuo Hirose, Hirohito Metoki, Azusa Hara, Kyoko Nomura, Atsushi Hozawa, Yoshitaka Tsubono, Yutaka Imai, Takayoshi Ohkubo
Summary: This study examined the association between hydrophilic and lipophilic antioxidant capacities of a Japanese diet and chronic kidney disease (CKD) risk. The findings suggest that a high intake of lipophilic antioxidants may be associated with a reduced risk of CKD, particularly in women. Achieving a balance between dietary antioxidant intake and pro-oxidants induced by unhealthy lifestyles may be crucial for preventing future kidney deterioration.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)
