Review
Chemistry, Multidisciplinary
Qasim Ali, Ilona Heldal, Carsten G. Helgesen, Gunta Krumina, Cristina Costescu, Attila Kovari, Jozsef Katona, Serge Thill
Summary: This study aims to explore the importance of vision screening for school-aged children and investigate how eye-tracking technologies can support this. By reviewing interdisciplinary research and discussing current challenges for technology support, the study highlights trends in supportive technologies for vision screening and the potential for developing more supportive ET technologies for non-experts conducting vision screening and training.
APPLIED SCIENCES-BASEL
(2021)
Article
Ophthalmology
Neha Misra, Rohit C. Khanna, Asha Latha Mettla, Srinivas Marmamula, Jill E. Keeffe
Summary: This study investigated the diagnostic accuracy and agreement of the spot vision screener (SVS) in screening preschool children for vision-related disorders. The findings showed that SVS demonstrated good diagnostic accuracy and agreement in identifying possible vision-related disorders in preschool children.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Shion Hayashi, Issaku Suzuki, Akira Inamura, Yaoko Iino, Koichi Nishitsuka, Sachiko Nishina, Hidetoshi Yamashita
Summary: The study compared the efficiency of conventional screening and SVS-based screening in detecting potential cases of amblyopia during the VTYOS. Results showed that SVS-based screening had higher success rates and positive predictive value, suggesting the addition of SVS-based screening to VTYOS.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hae Ri Yum, Yoo Yeon Park, Sun Young Shin, Shin Hae Park
Summary: This study evaluated the diagnostic performance of the Spot Vision photoscreener in detecting exotropia in preschool children. The results showed that the photoscreener had low sensitivity and should not be used alone for assessing exotropia in this population.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Hung-Da Chou, Tsung-Chieh Yao, Yu-Shu Huang, Chung-Ying Huang, Men-Ling Yang, Ming-Hui Sun, Hung-Chi Chen, Chun-Hsiu Liu, Shih-Ming Chu, Jen-Fu Hsu, Kuan-Jen Chen, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: Among school-aged children born prematurely, more time spent outdoors is associated with a lower odds of myopia. However, serum 25-hydroxyvitamin D concentration is not significantly associated with myopia, with a high proportion of participants having insufficient levels.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Pediatrics
Clara Martinez-Perez, Cristina Alvarez-Peregrina, Rita Brito, Miguel Angel Sanchez-Tena
Summary: The relationship between refractive errors and academic performance in school-aged children was investigated in this pilot study. Visual examination conducted on 252 children showed no significant differences in refractive state based on academic performance, but children with a negative spherical equivalent demonstrated better academic performance. Further studies with a larger sample size are needed to validate these findings and explore strategies for reducing myopia progression in schools.
Article
Ophthalmology
Zhuoer Qin, Tingting Peng, Zicheng Zhang, Jiangtao Lou, Chunxiao Wang, Ruzhi Deng, Meiping Xu, Xinping Yu, Wuhe Chen
Summary: The study found that school-aged children who develop myopia before the age of 10 are at risk for developing high myopia, with girls stabilizing their myopia slightly earlier than boys. Children with spherical equivalent larger than -4 D before the age of 10 have an 89.0% risk of developing high myopia at age 16, while children with spherical equivalent between -0.5 D and -2 D still have a 34% risk.
ACTA OPHTHALMOLOGICA
(2022)
Article
Psychology, Multidisciplinary
Deusa Priscila da Silva Resque, Adriany Maria de Moura Lobato, Carolina Gomes da Silva, Daniel Alves da Cruz Filho, Susanne Suely Santos da Fonseca, Felipe de Oliveira Matos, Antonio Pereira
Summary: Gender differences in spatial abilities favor males in both childhood and adulthood, which can be attributed to testosterone surge, societal stereotypes, and gender expectations. A spatial task was used to evaluate the performance of school-aged children, with boys performing better in letter rotation and girls performing better in the mirror task, showing the influence of societal attitudes and expectations. The age difference between younger and older girls in mental rotation may not be linked to reproductive steroids, while boys showed improvement in the inhibition of mirror generalization during reading acquisition.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Ophthalmology
Vishal Kapoor, Shaheen P. Shah, Timothy Beckman, Glen Gole
Summary: This study in Australia found that one in ten preschool children failed visual screening, and a 'hybrid' method combining failed NVAS and SVS had the highest predictive value in identifying ARFs and/or decreased visual acuity.
OPHTHALMIC EPIDEMIOLOGY
(2022)
Article
Nursing
Fernanda Manuela Loureiro, Ana Vanessa dos Reis Ameixa Antunes, Tiina Pelander, Zaida Borges Charepe
Summary: This study aimed to identify the best and worst experiences of school-aged children during hospitalisation. Results showed that children identified 'people', 'physical environment', 'activities', 'outcomes' and 'food' as best experiences, while the worst experiences included 'feelings', 'activities', 'food', 'environment' and 'outcomes'. Healthcare professionals should consider these findings to improve the hospitalisation experience for children.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Odile Feys, Pierre Corvilain, Alec Aeby, Claudine Sculier, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege, Florence Christiaens
Summary: This study compared the effectiveness of cryogenic and on-scalp MEG in detecting and localizing focal interictal epileptiform discharges (IEDs) in children with epilepsy. The results showed that on-scalp MEG had higher IED amplitudes and signal-to-noise ratios compared to cryogenic MEG, and the localization value was similar between the two modalities.
Review
Psychology, Multidisciplinary
Sofiane Souissi, Karim Chamari, Tarek Bellaj
Summary: This article examines current theories and models of Executive Functions (EF) in children, discusses assessment tools, issues, and challenges, and explores their impact on children's development. The assessment of EF requires considering multiple factors and further research is needed to improve assessment methods and validity.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Endocrinology & Metabolism
Jasmin M. de Groot, Madelon L. Geurtsen, Susana Santos, Vincent W. V. Jaddoe
Summary: Prevalence of liver fat accumulation and NAFLD differs between ethnic subgroups living in the Netherlands, especially for those with a Turkish background. Early-life factors have a strong influence on these associations and may hold clues for future preventive strategies.
Article
Public, Environmental & Occupational Health
Mijie Li, Chuen-Seng Tan, Lingqian Xu, Li-Lian Foo, Fabian Yap, Chen-Hsin Sun, Elaine K. H. Tham, Shirong Cai, Marcus Ang, Seang-Mei Saw, Charumathi Sabanayagam
Summary: In this study of elementary school-aged children in Singapore, various sleep factors such as quality, duration, timing, and consistency were not independently associated with myopia, spherical equivalent, and axial length. Large longitudinal studies are needed to verify these results.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Zihang Xu, Ziyun Wu, Ying Wen, Meihua Ding, Wei Sun, Yirong Wang, Zhen Shao, Yi Liu, Mingkun Yu, Guoyong Liu, Yuanyuan Hu, Hongsheng Bi
Summary: This study investigated the prevalence and associated factors of anisometropia in school-aged children in Shandong Province, China. The results showed that ocular parameters and lifestyle parameters were associated with the occurrence of anisometropia, including differences in axial length, habitual visual acuity, corneal astigmatism, stereoacuity, indoor near work time, and outdoor activity time. Preventing myopia and treating anisometropic amblyopia early may be effective in reducing the prevalence of anisometropia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
Aastha Khatiwada, Bethany J. Wolf, Jennifer K. Mulligan, Judy R. Shary, Martin Hewison, John E. Baatz, Danforth A. Newton, Catherine Hawrylowicz, Bruce W. Hollis, Carol L. Wagner
Summary: This double-blind RCT investigated the impact of plasma 25-hydroxyvitamin D (25(OH)D) on plasma immune-mediators during pregnancy. The study found that although baseline 25(OH)D was associated with TGF-β, IFN-γ, and IL-2, vitamin D supplementation during pregnancy did not significantly impact immune-mediators in later trimesters.
PEDIATRIC RESEARCH
(2021)
Article
Emergency Medicine
Matthew M. Moake, Bradley C. Presley, Jeanne G. Hill, Bethany J. Wolf, Ian D. Kane, Carrie E. Busch, Benjamin F. Jackson
Summary: This study aimed to evaluate the gastric content of pediatric emergency department patients undergoing procedural sedation and analgesia (PSA) using point-of-care ultrasound (POCUS). It found that the majority of patients had high-risk gastric content and fasting duration was not a good predictor of risk category.
PEDIATRIC EMERGENCY CARE
(2022)
Article
Ophthalmology
Robert W. Arnold, Sean P. Donahue, David Silbert, Susannah Q. Longmuir, Geoffrey E. Bradford, Mae Millicent W. Peterseim, Amy K. Hutchinson, James W. O'Neil, Alejandra G. de Alba Campomanes, Stacy L. Pineles
Summary: This study revised the guidelines and devices for pediatric vision screening, lowering the thresholds for amblyogenic anisometropia and raising the thresholds for symmetric astigmatism in order to identify risk factors more accurately. The study also emphasized the performance of screening instruments in detecting amblyopia and its impact on school performance.
Article
Environmental Sciences
Jacopo Umberto Verga, Matthew Huff, Diarmuid Owens, Bethany J. Wolf, Gary Hardiman
Summary: This review examines the effects of exposure to Endocrine Disrupting Chemicals (EDC) on human, animal, and environmental health. It explores the use of genomics technologies, specifically whole transcriptome sequencing, in risk assessment and toxicology studies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Brian Troyer, Jessalyn Rodgers, Bethany J. Wolf, James C. Oates, Richard R. Drake, Tamara K. Nowling
Summary: The development of nephritis increases the risk of morbidity and mortality in systemic lupus erythematosus patients. Standard induction therapies are only effective for approximately 50% of SLE patients with nephritis, and there is a critical need to predict treatment response before starting therapy. Elevated urine glycosphingolipids (GSLs) may serve as a potential biomarker for predicting treatment response in lupus nephritis patients.
Article
Biology
Rebecca Morgan, Dulcie Keeley, E. Starr Hazard, Emma H. Allott, Bethany Wolf, Stephen J. Savage, Chanita Hughes Halbert, Sebastiano Gattoni-Celli, Gary Hardiman
Summary: Men of African descent have a higher risk of developing and dying from prostate cancer compared to men of European descent. However, they are underrepresented in genetic studies and clinical trials. This study used computational approaches to compare fusion genes in prostate cancer between men of African and European descent, and identified novel fusion genes unique to African men.
Article
Anesthesiology
Rishi Ashok Patel, Jackson M. Condrey, Renuka M. George, Bethany J. Wolf, Sylvia H. Wilson
Summary: Sympathetic ganglion blocks (SGB) can effectively interrupt or treat electrical storm, and SGB catheters allow for prolonged arrhythmia cessation without repeated blocks. A retrospective cohort study found that 90% of patients achieved sustained cessation of electrical storm for 24 hours after left SGB, and 90% had no documented episodes of ventricular arrhythmias requiring intervention within 6 hours after SGB.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Letter
Ophthalmology
M. Millicent Peterseim
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Stephanie K. Jones, Anthony J. Alberg, Kristin Wallace, Brett Froeliger, Matthew J. Carpenter, Bethany Wolf
Summary: This study investigated the genetic associations with smoking relapse among female smokers throughout adulthood. The findings revealed specific genetic variations that are associated with the likelihood and proportion of relapse, especially among postmenopausal women.
CANCER PREVENTION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Luciani, Mauro Montalbano, Luca Troncone, Camilla Bacchin, Keita Uchida, Gianlorenzo Daniele, Bethany Jacobs Wolf, Helen M. Butler, Justin Kiel, Stefano Berto, Cortney Gensemer, Kelsey Moore, Jordan Morningstar, Thamonwan Diteepeng, Onder Albayram, Jose F. Abisambra, Russell A. Norris, Thomas G. Di Salvo, Benjamin Prosser, Rakez Kayed, Federica del Monte
Summary: This study found that Tau protein is expressed and aggregates in the heart tissue of patients with heart failure and Alzheimer's disease. Furthermore, monoclonal antibody therapy can improve heart function and clear toxic aggregates, suggesting that Tau may be a potential target for heart failure treatment.
EUROPEAN HEART JOURNAL
(2023)
Article
Mathematical & Computational Biology
Virginia B. Shipes, Caitlyn Meinzer, Bethany J. Wolf, Hong Li, Mathew J. Carpenter, Hooman Kamel, Renee H. Martin
Summary: Estimating sample size and subject accrual in multi-site time-to-event clinical trials is challenging. This study introduces a PERT model into the estimation process to account for site start-up delays and provide flexibility in power assessment and planning.
STATISTICS IN MEDICINE
(2023)
Article
Clinical Neurology
Sylvia H. Wilson, Joel M. Sirianni, Kathryn H. Bridges, Bethany J. Wolf, Isabella E. Valente, Michael D. Scofield
Summary: This study examined the use of N-acetylcysteine (NAC) for postoperative analgesia in patients undergoing spine surgery. The results showed that patients randomized to NAC consumed less opioids postoperatively and reported lower pain scores compared to the placebo group. Larger randomized controlled trials are needed to further evaluate the analgesic effect of NAC.
Article
Clinical Neurology
Loren Francis, Jackson Condrey, Christopher Wolla, Tara Kelly, Bethany Wolf, Ryan Mcfadden, Adam Brown, Sanford Zeigler, Sylvia H. Wilson
Summary: Anesthesia for cardiac surgery has evolved to incorporate non opioid analgesics and regional anesthesia for fast-track recovery. This retrospective cohort study compared the use of preoperative parasternal intercostal plane block catheters with postoperative ropivacaine infusions in patients undergoing cardiac surgery. The results demonstrated that while there was no significant difference in postoperative opioid consumption and pain scores, the use of block catheters was associated with reduced intraoperative opioid use, as well as decreased length of stay in the intensive care unit and hospital.
Article
Biochemistry & Molecular Biology
Kristy M. Waldrep, Jessalyn I. Rodgers, Sara M. Garrett, Bethany J. Wolf, Carol A. Feghali-Bostwick
Summary: Pulmonary fibrosis associated with systemic sclerosis is characterized by overexpression of insulin-like growth factor-II (IGF-II), which upregulates fibrosis-related molecules and contributes to the progression of the disease. Our study found that IGF-II enhances the expression of profibrotic signaling molecules and collagen-related enzymes in human lung fibroblasts. We also discovered that IGF-II induces the overexpression of SRY-box transcription factor 9 (SOX9) in lung fibroblasts, which further regulates the expression of fibrosis-related genes. These findings provide novel insights into the role of IGF-II in promoting pulmonary fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bethany Wolf, Calvin R. K. Blaschke, Sandy Mungaray, Bryan T. Weselman, Mariia Stefanenko, Mykhailo Fedoriuk, Hongxia Bai, Jessalyn Rodgers, Oleg Palygin, Richard R. Drake, Tamara K. Nowling
Summary: Lupus nephritis (LN) is a serious complication primarily affecting women with systemic lupus erythematosus. Our study found significant differences in lactosylceramide (LacCer) and N-linked glycosylated proteins (N-glycans) in the urine of LN patients, with more pronounced differences in males. Female-derived primary human renal mesangial cells (hRMCs) showed higher levels of calcium ion (Ca2+) flux, cytokine secretion, and glycosphingolipids compared to male-derived hRMCs when stimulated with LN sera. These findings suggest that urine LacCers and N-glycan profiles could serve as definitive biomarkers for LN, and the differences in males may indicate worse disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)