4.7 Article

A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 50, Pages 7818-7821

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc03163c

Keywords

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Funding

  1. National Natural Science Foundation of China [21190044, 21205032]
  2. Hunan Provincial Natural Science Foundation of China [13JJ4032]
  3. International Science & the Technology Cooperation Program of China [2010DFB30300]
  4. Fundamental Research Funds for the Central Universities
  5. Open Funding Project of the State Key Laboratory of Bioreactor Engineering

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A FRET-based sensor is anchored on the cell surface through streptavidin-biotin interactions. Due to the excellent properties of the pH-sensitive i-motif structure, the sensor can detect extracellular pH with high sensitivity and excellent reversibility.

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