4.7 Article

Structure and in vitro dissolution of Mg and Sr containing borosilicate bioactive glasses for bone tissue engineering

Journal

JOURNAL OF NON-CRYSTALLINE SOLIDS
Volume 533, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.jnoncrysol.2020.119893

Keywords

Borosilicate glasses; Bioactive glasses; Tissue engineering; Structural properties; In vitro dissolution

Funding

  1. Jane & Aatos Erkko Foundation (AGATE project)
  2. Academy of Finland
  3. DAAD

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Borosilicate bioactive glasses are promising for bone tissue engineering. The objective was to assess the impact of magnesium and/or strontium, when substituted for calcium on the glasses' thermal and dissolution properties. Both Mg and Sr substitution appeared to enhance the hot forming domain, i.e. the ability to hot process (sinter, draw fibres) without adverse crystallization. Structural analysis indicated that substitution of MgO and/or SrO for CaO results in changes in the BO3/BO4 ratio as well as in the ratio between bridging and non-bridging oxygen atoms in the silicate structure. Additionally, a de-shielding effect was noticed when Ca, Mg and Sr are present together in the glass network, possibly owing to PO43- charge-balanced preferentially by Na+. The Mg and/or Sr substitution resulted in a lower ion release in simulated body fluid and delayed formation of hydroxyapatite. However, once this layer formed it consisted of a Mg/Sr-substituted apatite. This work highlights the effect of combined ionic substitutions on bioactive glass structure and properties.

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