Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 335, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneumeth.2020.108629
Keywords
Virus; Gene delivery; Lineage tracing; Circuit mapping; Gene therapy; Cell type
Categories
Funding
- National Key RAMP
- D Program of China [2018YFA0108000]
- National Natural Science Foundation of China [31771196, 31471037]
- Shanghai Science and Technology Commission Innovation Fund [17JC1401500]
- Shanghai Commission of Health Youth Program [2017YQ016]
- Shanghai RisingStar Program [18QA1400600]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ZJLab
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Viral vectors are widely used to study the development, function and pathology of neural circuits in the mammalian brain. Their flexible payloads with customizable choices of tool genes allow versatile applications ranging from lineage tracing, circuit mapping and functional interrogation, to translational and therapeutic applications. Different applications have distinct technological requirements, therefore, often utilize different types of virus. This review introduces the most commonly used viruses for these applications and some recent advances in improving the resolution and throughput of lineage tracing, the efficacy and selectivity of circuit tracing and the specificity of cell type targeting.
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