Suppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia

Differential regulation of GSK-3β in spinal dorsal horn and in hippocampus mediated by IL-1β contributes to pain hypersensitivity and memory deficits following peripheral nerve injury

(2019) Chun-Lin Mai et al.   Molecular Pain

Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation

(2019) Venkatesh Pooladanda et al.   Cell Death & Disease

Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain

(2018) Xinran Hou et al.   NEUROSCIENCE

Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats

(2018) Xiao-Tao He et al.   Frontiers in Pharmacology

Suberoylanilide Hydroxamic Acid Triggers Autophagy by Influencing the mTOR Pathway in the Spinal Dorsal Horn in a Rat Neuropathic Pain Model

(2018) Xiang-Lan Feng et al.   NEUROCHEMICAL RESEARCH

The effects of conditioned media generated by polarized macrophages on the cellular behaviours of bone marrow mesenchymal stem cells

(2017) Xiao-Tao He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells

(2017) Xiao-Fan Hu et al.   Journal of Neuroinflammation

Histone deacetylase 2 is involved in �‑opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain

(2017) Yong‑Hui Liao et al.   Molecular Medicine Reports

Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain

(2017) Yul Huh et al.   Frontiers in Immunology

Targeting glia for bone cancer pain

(2016) Ya-Qun Zhou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke

(2016) Radhika Patnala et al.   MOLECULAR NEUROBIOLOGY

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells

(2015) Daniela Carlisi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

(2015) Chung-Hsi Hsing et al.   MEDIATORS OF INFLAMMATION

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic mechanisms of chronic pain

(2015) Giannina Descalzi et al.   TRENDS IN NEUROSCIENCES

Glial epigenetics in neuroinflammation and neurodegeneration

(2014) Ori Staszewski et al.   CELL AND TISSUE RESEARCH

Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain

(2014) Sarah Falk et al.   JOURNAL OF CLINICAL ONCOLOGY

CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord

(2014) Wen Shen et al.   Journal of Neuroinflammation

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia

(2014) V. Singh et al.   NEUROSCIENCE

Osteoclasts: more than ‘bone eaters’

(2014) Julia F. Charles et al.   TRENDS IN MOLECULAR MEDICINE

HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model

(2013) Yosuke Matsushita et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain

(2013) Han-Rong Weng et al.   EXPERIMENTAL NEUROLOGY

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia

(2013) Vishnu Kannan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Epigenetics: A Promising Paradigm for Better Understanding and Managing Pain

(2013) Seungmae Seo et al.   JOURNAL OF PAIN

Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats

(2013) Chen-Hwan Cherng et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Histone deacetylase inhibition leads to neuroprotection through regulation on glial function

(2013) Xuefei Wu et al.   Molecular Neurodegeneration

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

(2013) Franziska Denk et al.   PAIN

Bone cancer pain: Causes, consequences, and therapeutic opportunities

(2013) Patrick Mantyh   PAIN

Neuropathic pain and cytokines: current perspectives

(2013) Marzia Malcangio et al.   Journal of Pain Research

The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ

(2012) Sadayuki Hashioka et al.   Journal of Neuroinflammation

Global cancer transitions according to the Human Development Index (2008–2030): a population-based study

(2012) Freddie Bray et al.   LANCET ONCOLOGY

Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

(2012) Franziska Denk et al.   NEURON

Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: Evidence for the mechanisms of action

(2012) L. Mazzardo-Martins et al.   NEUROSCIENCE

Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats

(2012) Qi-Liang Mao-Ying et al.   Molecular Brain

SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells

(2011) M. Lauricella et al.   BIOCHIMIE

Epigenetic suppression of GAD65 expression mediates persistent pain

(2011) Zhi Zhang et al.   NATURE MEDICINE

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

(2011) Fernando Correa et al.   NEUROBIOLOGY OF DISEASE

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

(2011) Stephen J. Haggarty et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells

(2010) Hyun Chang et al.   BREAST CANCER RESEARCH AND TREATMENT

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of Class II Histone Deacetylases in the Spinal Cord Attenuates Inflammatory Hyperalgesia

(2010) Guang Bai et al.   Molecular Pain

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Valproate attenuates the development of morphine antinociceptive tolerance

(2010) Tamae Dobashi et al.   NEUROSCIENCE LETTERS

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo

(2009) Giuseppe Faraco et al.   NEUROBIOLOGY OF DISEASE

Sp1-Mediated TRAIL Induction in Chemosensitization

(2008) J. Xu et al.   CANCER RESEARCH

Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain

(2008) Andreas Hald et al.   EUROPEAN JOURNAL OF PAIN

Spinal glial activation contributes to pathological pain states

(2008) Hong Cao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

(2008) A. J. Frew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA