Article
Chemistry, Multidisciplinary
Yingying Chen, Xue Gong, Yuhui Gao, Yu Shang, Jinhua Shang, Shanshan Yu, Ruomeng Li, Shizhen He, Xiaoqing Liu, Fuan Wang
Summary: Introducing a novel endogenous DNA repairing enzyme-powered pre-selection strategy, a cancer cell-selective catalytic DNA circuit for imaging microRNA with high anti-interference capacity was developed. This circuit offers a reliable amplification strategy for intracellular biomarker assays in living systems.
Article
Chemistry, Multidisciplinary
Pei Dong, Ruomeng Li, Shizhen He, Qingqing Zhang, Jinhua Shang, Yuqian Jiang, Xiaoqing Liu, Fuan Wang
Summary: The accurate identification of multiple biomarkers involved in disease is crucial for distinguishing cancer cells from normal cells and facilitating reliable cancer diagnosis. In this study, a compact and clamped cascaded DNA circuit was engineered to specifically discriminate cancer cells from normal cells using the amplified multi-microRNA imaging strategy. The proposed DNA circuit combined the traditional cascaded DNA circuit with multiply localized responsive character, streamlining the circuit components and realizing localization-intensified cascaded signal amplification. The sequential activations of the compact circuit by multiple microRNAs, combined with a handy logic operation, significantly improved the cell-discriminating reliability.
Article
Chemistry, Analytical
Cheng Fang, Yuming Li, Song Hu, Hao Wang, Xiaoxia Chen, Xiaoli Zhu
Summary: The developed DNA tree in this study enables amplified analysis of mRNA in living cells, achieving sensitive, accurate, and nondestructive analysis. The probes are transported into cells by exosomes, are LDNAs resistant to degradation, laying the foundation for reliable analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mengni Sun, Na Ma, Hanxing Shi, Ling-Zhi Cheong, Wenge Yang, Zhaohui Qiao
Summary: A multivalent aptamer based on hybridization chain reaction (HCR) was designed as an effective signal amplifier for the sensitive detection of Salmonella. The multi-Apt exhibited a 33-fold enhancement in binding affinity and faster reaction kinetics compared to the monovalent aptamer (mono-Apt). By utilizing the HCR scaffold as a signal carrier, the proposed HCR-based multi-Apt amplifier could detect Salmonella as low as 7 cfu mL-1 with a broad detection range of 10 to 107 cfu mL-1. It also demonstrated excellent specificity against target bacteria and performed well on the detection of spiked food samples, showing great potential in practical Salmonella detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Duoduo Zhang, Kan Wang, Wei Wei, Yong Liu, Songqin Liu
Summary: The study constructed a multifunctional plasmonic core-satellites nanoprobe for clinical cancer diagnosis and therapy, which can be used for miRNA detection, targeting drug release, and therapy evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yan Shan Ang, Lin-Yue Lanry Yung
Summary: This study reports the impact of fluorophore-quencher labelling on the thermodynamics of DNA hairpin opening and proposes two counter strategies to address this issue.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yan Shan Ang, Lin-Yue Lanry Yung
Summary: This study reports the impact of fluorophore-quencher labelling on the thermodynamics of DNA hairpin opening and introduces two counter strategies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Feng Qiu, Xiaoyan Gan, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: This study presents a novel method for sensitive detection of thrombin in human serums. By utilizing target-promoted magnetic nanoparticle-decorated DNA polymers for proximity binding hybridization chain reaction, the detection of thrombin is significantly enhanced.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shiyi Wang, Ziwen Zong, Jianguo Xu, Bangben Yao, Zhou Xu, Li Yao, Wei Chen
Summary: In this study, a visual strategy for rapid and ultrasensitive detection of OTA was proposed by integrating primer-mediated exponential rolling circle amplification (P-ERCA) with a designed nucleic acid lateral flow strip (LFS). This method demonstrates highly sensitive detection of OTA and could be utilized as a universal method for detection of other chemical analytes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lei Liao, Xiaolong Li, Bingying Jiang, Wenjiao Zhou, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescence aptamer sensor was developed for the detection of trace kanamycin in milk samples with high selectivity and sensitivity. The sensor utilized a label- and enzyme-free signal enhancement approach by coupling catalytic hairpin assembly (CHA) with nonlinear hybridization chain reaction (nHCR). The results showed that the sensor achieved sensitive sensing of kanamycin in the dynamic range of 0.1-300 nM with a detection limit of 46.1 pM. Moreover, the sensor demonstrated the ability to selectively monitor kanamycin in spiked milk samples. This signal amplification strategy has the potential to be a sensitive and convenient method for monitoring various antibiotics.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Junyang Wang, Hongxia Li, Caiyi Du, Ying Li, Xinyue Ma, Chuanyu Yang, Wentao Xu, Chunyan Sun
Summary: A novel aptasensor for tobramycin was successfully constructed using hybridization chain reaction (HCR) and fluorescence synergism. The aptasensor showed low detection limit and could monitor tobramycin in a wide concentration range. The amplification of fluorescence signal was achieved through HCR and the released cDNA-FAM acted as an initiator to trigger the amplification. Graphene oxide effectively quenched the background signal, enabling sensitive and specific detection of tobramycin.
Review
Chemistry, Multidisciplinary
Hongxing Li, Xun Li, Shaoguang Li, Zhiwei Shang, Hui Li, Fan Xia
Summary: Electrochemical biosensors are emerging sensor technologies that use amplification strategies to achieve ultrasensitivity for specific analytes. Hybridization chain reaction (HCR) is a cost-effective and enzyme-free amplification strategy that has been coupled with electrochemistry to enhance the sensitivity of biosensors. This review summarizes the significant achievements of HCR-amplified electrochemical biosensors in the past decade, including their design, challenges, and opportunities.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jing Zhang, Meifeng Hou, Guanyu Chen, Huifang Mao, Wenqian Chen, Wenshen Wang, Jinghua Chen
Summary: An electrochemical biosensor based on DNA nano-bridge was developed for detecting exosomal miR-21 with high sensitivity and selectivity, showing potential application in early diagnosis of cancer.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Analytical
Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Jun Chen, Zong Dai
Summary: This study presents a Hairpins@MnO2 nanosystem for intracellular enzyme-free exponential amplification for miRNA imaging. The method combines hybridization chain reaction (HCR) and DNAzymes for efficient miRNA detection. The introduced nanosystem allows for a highly sensitive and specific detection of miRNA expression in living cells, with a detection limit 2.4 x 10(4) times lower than traditional HCR system.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Jun Chen, Zong Dai
Summary: The Hairpins@MnO2 nanosystem enables enzyme-free exponential amplification for miRNA imaging in living cells, offering high sensitivity and specificity. The method combines HCR and DNAzymes for efficient amplification, with a detection limit much lower than traditional HCR systems. It allows accurate differentiation of miRNA expression in cancer cells and normal cells, showing great potential in nucleic acid biological research.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)