Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 5, Pages 1505-1514Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01167
Keywords
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Funding
- National Natural Science Foundation of China [31770380, 21572073, 31270394, 3150010539]
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Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (1a, 1b and 2), eight new 14-membered RALs (3-10), and one new 12-membered RAL (11), along with five known 14-membered RALs (12-16), were identified from the fermentation of the soil-derived fungus Ilyonectria sp. sb65. Their structures were established by detailed analyses of 1D and 2D NMR, HRESIMS, and X-ray diffraction crystallography. All new compounds were evaluated for their cytotoxic effects against three human cancer cell lines, along with their potential as TRAIL sensitizers in TRAIL-resistant A549 human lung adenocarcinoma cells and their in vitro immunosuppressive effects against ConA-induced T-cell and LPS-induced B-cell proliferation.
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