Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 4, Pages 852-863Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00469
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Funding
- National Council for Scientific and Technological Development (CNPq)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Brazil
- Fund for Scientific Research (FWO), Vlaanderen, Belgium
- Swiss National Science Foundation [316030_164095]
- Swiss National Science Foundation (SNF) [316030_164095] Funding Source: Swiss National Science Foundation (SNF)
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Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two beta-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol (16). Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 mu M, respectively.
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