Article
Biotechnology & Applied Microbiology
Xinwei Sun, Qingyu Liu, Jie Huang, Ge Diao, Zhiqing Liang
Summary: Research on the relationship between cancer stem cells and chemoresistance in serous ovarian cancer revealed potential drug-response indicators and prognostic genes, offering new insights for clinical treatments in advanced SOC patients.
Article
Cell Biology
Qi-Ying Yu, Zhi-Wen Wang, Meng-Ying Zhou, Shang-Fu Li, Xing-Hua Liao
Summary: Gastric cancer is a highly lethal malignant disease of the digestive tract. This study aimed to identify regulatory factors of tumor stem cells in gastric cancer and construct a risk prognostic model using co-expression network and regression analysis. A sixteen-gene model was obtained and further experiments confirmed the role of MAGE-A3 as a regulator of tumor stemness. This research provides important insights for the prediction and treatment of gastric cancer.
Article
Gastroenterology & Hepatology
Jia-Liang Cai, Gui-Qi Zhu, Jun-Xian Du, Biao Wang, Jing-Lei Wan, Kun Xiao, Zhi Dai
Summary: Stem cell-related gene expression in HCC was characterized using mRNAsi, leading to the identification of a six-gene signature that accurately predicts patient prognosis, with the low-risk group showing a significantly better prognosis. Future prospective studies are needed to validate the new signature for clinical decision-making.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaofang Wang, Xuan Luo, Zhiyuan Wang, Yanghao Wang, Juan Zhao, Li Bian
Summary: This study identified CBFA2T3 and DENND3 as key genes associated with cancer stemness and M2 macrophages in lung adenocarcinoma (LUAD), and investigated their relationship with clinical characteristics and potential mechanisms. The results showed that CBFA2T3 and DENND3 were significantly correlated with overall and disease-free survival of LUAD patients, and their expression could accurately classify LUAD and control samples. These findings have important implications for the diagnosis and treatment of lung adenocarcinoma.
Article
Genetics & Heredity
Shaohui Hou, Hongrui Xu, Shuzhong Liu, Bingjun Yang, Li Li, Hui Zhao, Chunyang Jiang
Summary: In this study, a 9-gene signature associated with the prognosis of lung adenocarcinoma (LUAD) patients was identified and a predictive model was developed. This model can contribute to decisions in the treatment and prevention of LUAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Yue Huang, Zhuo Zhang, Meijuan Sui, Yang Li, Yi Hu, Haiyu Zhang, Fan Zhang
Summary: This study characterized stem cell-related gene expression in AML and identified eight stemness biomarker genes. Patients in stemness subgroup I had a poor prognosis and benefited from specific treatments. The mRNAsi score showed a significant negative correlation with the immune score.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Bin Zhang, Yang He, Gui Ma, Lili Zhang, Peng Qi, Dali Han, Zhongjin Yue, Panfeng Shang
Summary: This study identified 25 biomarkers associated with stemness indices in bladder cancer and established a ceRNA network based on key mRNAsi-related genes. SNHG12 was found to promote proliferation, invasion, migration, apoptosis, and stemness in bladder cancer.
MOLECULAR AND CELLULAR PROBES
(2022)
Article
Genetics & Heredity
Chunmei Ban, Feiyan Yang, Min Wei, Qin Liu, Jiankun Wang, Lei Chen, Liuting Lu, Dongmei Xie, Lie Liu, Jinxiong Huang
Summary: This study investigated the use of stemness index in predicting prognosis of multiple myeloma (MM) and identified 127 stemness-related genes primarily involved in cell cycle, differentiation, DNA replication and repair. By clustering MM patients into three MM stemness (MMS) clusters, it was found that samples in MMS-cluster3 had the highest stemness fractions and worst prognosis. Additionally, lower immune infiltration was observed in MMS-cluster3, suggesting a negative correlation between stemness and anticancer immunity. The study also proposed a prognostic nomogram for individualized assessment of MM patients' overall survival probabilities.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Chunyu Zhang, Haitao Liu, Pengfei Xu, Yinqiu Tan, Yang Xu, Long Wang, Baohui Liu, Qianxue Chen, Daofeng Tian
Summary: In this study, we identified a five-lncRNA signature that can be used as a reliable tool for predicting the survival of glioma patients. The signature showed high predictive accuracy in different cohorts and was validated as an independent prognostic indicator.
Article
Oncology
Guangwen Wang, Zhenhua Wu, Yesheng Huang, Yingbang Li, Yunpeng Bai, Zhidan Luo, Wendong Huang, Zanxiong Chen
Summary: This study identified key genes related to stomach adenocarcinoma stem cell characteristics and found that the mRNA stemness index was closely related to the clinical characteristics and survival status of stomach adenocarcinoma. The cell-cycle pathway was identified as the most important signaling pathway for these key genes associated with stomach adenocarcinoma stem cells.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Yin Weng, Nicole Salazar
Summary: This study analyzed DNA methylation data from lower-grade glioma and glioblastoma multiforme patients, identifying ten methylation markers associated with glioma grade. These markers, strongly linked to specific molecular alterations, can predict patient survival probabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Zhi-Yu Chen, Huan-Huan Huang, Qiao-Chu Li, Fang-Biao Zhan, Ling-Bang Wang, Tao He, Chao-Hua Yang, Yang Wang, Yuan Zhang, Zheng-Xue Quan
Summary: Previous studies have shown that capsaicin can inhibit osteosarcoma proliferation and enhance its sensitivity to cisplatin. This study further explored the inhibitory effects of capsaicin at low concentrations on stemness and metastasis of osteosarcoma. The results demonstrated that capsaicin can significantly reduce the number of osteosarcoma cancer stem cells and inhibit their invasive and metastatic abilities. This has important implications for the prevention and treatment of osteosarcoma metastasis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Oncology
Zhi Wang, Di Wu, Yu Xia, Bin Yang, Tao Xu
Summary: The study identified 72 hub genes closely linked to ovarian cancer stem cell characteristics, primarily involved in cell division and proliferation. Furthermore, compounds that may disturb these hub genes were identified as potential treatments targeting ovarian cancer stem cells.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Negin Taghehchian, Reza Alemohammad, Moein Farshchian, Ahmad Asoodeh, Mohammad Reza Abbaszadegan
Summary: This study aimed to investigate the clinical significance and biological function of long non-coding RNA LINC00332 in gastric cancer (GC). The results showed that LINC00332 was downregulated in GC tissues and had a negative correlation with MMP-13 expression. Overexpression of LINC00332 inhibited the proliferation, migration, and invasion of GC cells, and reduced cisplatin resistance.
Article
Cell & Tissue Engineering
Yujia Zhang, Fengjun Qiu, Tingjie Ye, Sau Har Lee, Jiatuo Xu, Lingyan Jia, Rui Zeng, Xiaoling Wang, Xudong Hu, Xiaofeng Yan, Hua Li, Yanlin Lu, Rilei Jiang, Wei Xu
Summary: This study identified a signature of 6 resistance genes associated with chemoresistance in lung cancer patients. The EREG/ErbB pathway was found to regulate stemness and maintain chemoresistance through the ERK signaling pathway in NSCLC. Targeting EREG/ErbB could effectively resolve the issue of chemoresistance.
STEM CELL RESEARCH & THERAPY
(2022)