Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Bettsy Y. Recalde, Robertino M. Mera
Summary: This study aimed to assess whether COVID-19-related cognitive decline is a permanent deficit or if it improves over time. The results suggest that long COVID-related cognitive decline may spontaneously improve over time.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Micaela Sandoval, Duc T. Nguyen, Howard J. Huang, Stephanie G. Yi, R. Mark Ghobrial, A. Osama Gaber, Edward A. Graviss
Summary: This investigation found that COVID-19 mortality may be significantly reduced among immunosuppressed SOT recipients within 6 months following vaccination.
Article
Public, Environmental & Occupational Health
Daniele Colombo, Franca Del Nonno, Roberta Nardacci, Laura Falasca
Summary: SARS-CoV-2 infection can lead to tongue swelling, which is believed to be caused by angioedema. Genetic predisposing factors and ACE inhibitors have been suggested as possible causes of angioedema, but other unrecognized factors should also be considered. This case report describes a patient who died from COVID-19 and developed macroglossia, without a family history of angioedema or ACE inhibitors use. Histological analysis revealed tongue muscle atrophy and infiltrating macrophages, suggesting nerve injury repair mechanisms.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Immunology
Yue Zhou, Xuelian Liao, Xiangrong Song, Min He, Fei Xiao, Xiaodong Jin, Xiaoqi Xie, Zhongwei Zhang, Bo Wang, Chenliang Zhou, Yan Kang, Wei Zhang
Summary: During the COVID-19 pandemic, some critically ill patients were unable to be discharged from the ICU despite negative viral tests, leading to a study on the gene expression profiles of peripheral immune cells. The findings showed severely decreased expression of adaptive immunity-related genes in these patients, particularly related to T/B cells and HLA molecules, resulting in long-term secondary infections. No significant change was observed in classic immunosuppression molecules, suggesting that this adaptive immune suppression may be caused by dysregulated host response to severe infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Hong Zhao, Chi Zhang, Xian-Xiang Chen, Qi Zhu, Wen-Xiang Huang, Yi-Lan Zeng, Ying-Xia Liu, Guo-Jun Li, Wei-Jun Du, Jing Yao, Jia-Wen Li, Peng Peng, Gui-Qiang Wang
Summary: This study found that the duration of SARS-CoV-2 RNA positivity was associated with an increased risk of recurrent positive, especially for patients with an SPD of over 28 days compared to those with less than 14 days. Additionally, the risk of recurrent positive may be higher among patients with hypertension and lower monocyte count or percentage.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Multidisciplinary Sciences
Wiktoria Budziar, Katarzyna Gembara, Marek Harhala, Aleksander Szymczak, Natalia Jedruchniewicz, Krzysztof Baniecki, Aleksandra Pikies, Artur Nahorecki, Agnieszka Hoffmann, Amelia Kardas, Alina Szewczyk-Dabrowska, Tomasz Klimek, Zuzanna Kazmierczak, Wojciech Witkiewicz, Kamil Barczyk, Krystyna Dabrowska
Summary: This study investigated the population immunity to SARS-CoV-2 among healthy individuals in Poland and found that 35.5% tested positive for SARS-CoV-2-specific IgG and 52.3% tested positive for SARS-CoV-2-specific IgA. Among the participants, 21.2% developed virus-specific IgG or IgA while being asymptomatic.
Article
Oncology
Laura Mansi, Laurie Spehner, Etienne Daguindau, Kevin Bouiller, Hamadi Almotlak, Ulrich Stein, Adeline Bouard, Stefano Kim, Elodie Klajer, Marine Jary, Guillaume Meynard, Angelique Vienot, Charlee Nardin, Fernando Bazan, Quentin Lepiller, Virginie Westeel, Olivier Adotevi, Christophe Borg, Marie Kroemer
Summary: Cancer patients exposed to SARS-CoV-2 produced a high rate of specific antibodies, but lacked T-cell responses against the virus, indicating a deficiency in protective T-cell immunity. However, their immune memory against common viruses remained intact.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Leyuan Liu, Xiaoxiao Wang, Xiaoguang Li, Nan Li
Summary: The study shows that COVID-19 vaccination can reduce public anxiety and promote willingness for future antibody testing, with those experiencing higher levels of anxiety more likely to undergo antibody testing.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Yu Tian, Kai-yi Sun, Tian-qing Meng, Zhen Ye, Shi-meng Guo, Zhi-ming Li, Cheng-liang Xiong, Ying Yin, Hong-gang Li, Li-quan Zhou
Summary: Recent studies suggest that COVID-19 may lead to intestinal tissue infection and alter the gut microbiota, with these changes potentially not fully restored in recovered patients. Differences in bacterial diversity, species, and relative abundance were observed between recovered COVID-19 male patients and healthy controls.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Han-Sol Park, Janna R. Shapiro, Ioannis Sitaras, Bezawit A. Woldemeskel, Caroline C. Garliss, Amanda Dziedzic, Jaiprasath Sachithanandham, Anne E. Jedlicka, Christopher A. Caputo, Kimberly E. Rousseau, Manjusha Thakar, San Suwanmanee, Pricila Hauk, Lateef Aliyu, Natalia Majewska, Sushmita Koley, Bela Patel, Patrick Broderick, Giselle Mosnaim, Sonya L. Heath, Emily S. Spivak, Aarthi Shenoy, Evan M. Bloch, Thomas J. Gniadek, Shmuel Shoham, Arturo Casadevall, Daniel Hanley, Andrea L. Cox, Oliver Laeyendecker, Michael J. Betenbaugh, Steven M. Cramer, Heba H. Mostafa, Andrew Pekosz, Joel N. Blankson, Sabra L. Klein, Aaron A. R. Tobian, David Sullivan, Kelly A. Gebo
Summary: Benchmarks for protective immunity from infection or severe disease after SARS-CoV-2 vaccination are still being defined. In this study, the researchers compared different immune responses and viral variants in different groups, including vaccinated individuals and symptomatic patients. The findings showed that neutralizing antibody levels declined over time and were lower against the Alpha variant. Partially and fully vaccinated patients had lower neutralizing antibody levels against the parent virus compared to healthy controls. The study also found that neutralization activity against the Alpha variant was lower in the partially and fully vaccinated infected patients. Parent virus neutralization was identified as a predictive factor for breakthrough infections with the Alpha variant.
Review
Medicine, General & Internal
Mariam Nikolaishvili, Ani Pazhava, Vito Di Lernia
Summary: Henoch-Schonlein purpura, also known as IgA vasculitis, is a common type of vasculitis in children and adults. It affects small blood vessels and can cause skin and systemic symptoms, with some patients developing kidney failure. The specific pathophysiology of this disorder is not well understood, but it is believed to be related to abnormally glycosylated IgA1. Various factors, including infections, drugs, and vaccines, can trigger the condition. In the context of the COVID-19 pandemic, SARS-CoV-2 infection and COVID-19 immunization have been identified as significant triggers for IgA vasculitis. This review provides insights into the relationship between viral infections, viral vaccines, and Henoch-Schonlein purpura.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Zhongshan Cheng, Yi Cai, Ke Zhang, Jingxuan Zhang, Hongsheng Gui, Yu-Si Luo, Jie Zhou, Brian DeVeale
Summary: Through an integrative analysis of two genome-wide association studies, we identified ancestry-linked genetic risk variants associated with COVID-19 hospitalization and identified four more frequent single nucleotide polymorphisms in COVID-19-hospitalized patients with non-European ancestry. Among them, the COVID-19 risk SNP rs16831827 showed the largest difference in minor allele frequency (MAF) between populations with African and European ancestry and also exhibited higher MAF in hospitalized COVID-19 patients with mixed ancestry (odds ratio [OR] = 1.20, 95% CI: 1.10-1.30) and entirely African ancestry (OR = 1.30, 95% CI: 1.02-1.67). rs16831827 is an expression quantitative trait locus of MAP3K19, which is highly expressed in ciliated tissues including lungs, and its reduced expression may increase the risk of severe COVID-19.
News Item
Multidisciplinary Sciences
Roxanne Khamsi
Summary: Evidence suggests that self-attacking autoantibodies may be crucial in understanding some of the most severe cases of SARS-CoV-2 infection.
Review
Immunology
Ying Wang, Pengfei Huo, Rulin Dai, Xin Lv, Shaofei Yuan, Yang Zhang, Yiming Guo, Rui Li, Qian Yu, Kun Zhu
Summary: The effectiveness of convalescent plasma (CP) immunotherapy for COVID-19 in reducing mortality and improving clinical symptoms remains controversial based on current evidence, but it may have a positive impact on treating COVID-19 patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Allison N. Grossberg, Lilia A. Koza, Aurelie Ledreux, Chad Prusmack, Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Ann-Charlotte Granholm, Daniel A. Linseman
Summary: This study presents results from a multiplex serology test for assessing COVID-19 antibody responses, showing distinct dynamics of IgG, IgM, and IgA responses in patients with different disease severity. It suggests that antibody responses to SARS-CoV-2 may serve as important biomarkers for assessing the risk of viral transmission.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Erika L. Fuchs, Jacqueline M. Hirth, Fangjian Guo, V. Gnaukita Brown, Leslie Cofie, Abbey B. Berenson
Summary: The study examined infant vaccination education preferences among low-income pregnant women, finding that incorporating vaccination education into prenatal nurse-led programs would be well accepted in this population.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Oncology
Fangjian Guo, Jacqueline M. Hirth, Erika L. Fuchs, Leslie E. Cofie, Veronica Brown, Yong-Fang Kuo, Maria E. Fernandez, Abbey B. Berenson
Summary: Knowledge, attitudes, and patient preferences about genetic testing and subsequent risk management for cancer prevention among average risk populations, especially among Hispanics, are understudied. This study assessed these aspects by conducting in-person surveys among young women. The findings indicate that in this low-income, mostly Hispanic population, there is poor knowledge about genetic testing and cancer risk, but most individuals have positive opinions about genetic testing for cancer prevention. However, they show a stronger preference for chemoprevention and a lesser preference for prophylactic surgeries in a hypothetical scenario, highlighting the importance of genetic counseling and education.
JOURNAL OF CANCER EDUCATION
(2022)
Letter
Virology
Yufeng Shang, Tao Liu, Jingfeng Li, Xinghuan Wang, Fuling Zhou
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Hui-Hui Zhang, Chao Li, Jian-Wei Ren, Lian Liu, Xue-Hua Du, Jie Gao, Tao Liu, Shang-Ze Li
Summary: The study reveals that OTUB1 promotes bladder cancer progression by stabilizing ATF6, and raised expression of OTUB1 in bladder cancer patients has drawn attention. Genetic ablation of OTUB1 significantly inhibits bladder cancer cell proliferation, viability, and migration.
Article
Immunology
Yufeng Shang, Tao Liu, Jingfeng Li, Natasha Mupeta Kaweme, Xinghuan Wang, Fuling Zhou
Summary: The study found that the absence of IgG antibody conversion in some COVID-19 patients may indicate disease progression to a severe state, while factors such as advanced age, dyspnea, and gasping are associated with illness worsening. Patients with prominent clinical symptoms are more likely to generate IgG antibody responses, and factors such as fever, cancer, cephalosporins, and antimalarial drugs are associated with IgG response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu, Tao Liu
Summary: This study identified MINDY1 as a deubiquitinating enzyme of YAP in bladder cancer, demonstrating its role in interacting with, deubiquitinating, and stabilizing YAP. Depletion of MINDY1 led to decreased cell proliferation in bladder cancer, which could be rescued by YAP overexpression, affecting the expression of YAP and its target genes.
CANCER CELL INTERNATIONAL
(2021)
Meeting Abstract
Oncology
Fangjian Guo, Mihyun Chang, Abbey Berenson
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Fangjian Guo, Lyuba Levine, Abbey Berenson
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Virology
Yufeng Shang, Yuxing Liang, Tao Liu, Jingfeng Li, Fuling Zhou
Summary: Early detection and intervention are crucial for improving outcomes in COVID-19 patients. Molecular assays and antibody testing play important roles in COVID-19 diagnosis. Differences in infection rates and gender disparities were observed in different patient groups.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Letter
Oncology
Abbey B. Berenson, Fangjian Guo, Mihyun Chang
Review
Biochemistry & Molecular Biology
Yang Liu, Shujun Zhou, Du Xiang, Lingao Ju, Dexin Shen, Xinghuan Wang, Yanfeng Wang
Summary: Acute lung injury (ALI) is a condition caused by various factors leading to acute hypoxic respiratory insufficiency, with oxidative stress playing a significant role in its pathogenesis. While antioxidants can alleviate ALI by scavenging ROS, they may have no significant effect and could even aggravate severe organ injury.
Article
Public, Environmental & Occupational Health
Fangjian Guo, Matthew Scholl, Erika L. Fuchs, Abbey B. Berenson, Yong-Fang Kuo
Summary: Since the discovery of BRCA1 and BRCA2 pathogenic variants, genetic testing has been recommended for cancer prevention and treatment. This study assessed the trends in BRCA test rates and results among US women aged 18 to 65 between 2007 and 2017. The results showed that the test rates increased while the documented positive results decreased. The utilization and outcomes of testing varied significantly across races/ethnicities.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Oncology
Fangjian Guo, Mihyun Chang, Matthew Scholl, Brian McKinnon, Abbey B. Berenson
Summary: This study investigated the impact of HPV vaccination on the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) in the US. The results showed a decrease in the incidence of HPV-related OPSCC among young adults during the vaccination era, but no improvement in cancer-specific 5-year survival for young females.
FRONTIERS IN ONCOLOGY
(2022)
Article
Computer Science, Information Systems
Shixiao Wu, Xinghuan Wang, Chengcheng Guo
Summary: During feature propagation, the low-level convolution layers in the forward feature propagation network lack semantic information, leading to information loss when transferring fine-grained information to higher-level convolution layers. To address this, a multi-stage feature fusion network is introduced to handle the interaction between low-level and high-level convolution layers. By incorporating a two-way feature feedback network and feature fusion mechanism, a new object detection network called Feature Pyramid Network (FPN)-based Feature Fusion Single Shot Multibox Detector (FFSSD) is developed. The proposed network achieves a mAP of 83.58% for prostate capsule image detection, demonstrating real-time detection capability. The context interaction mechanism effectively transfers high-level semantic information to low-level convolution layers, resulting in convolution with richer location and semantic information.
Article
Oncology
Fangjian Guo, Victor Adekanmbi, Christine D. Hsu, Abbey B. Berenson
Summary: We compared the incidence rates of HPV-related cancers before and after the introduction of HPV vaccines in the United States. The results show that the incidence rates of HPV-related cancers among females aged 15-24 years and 25-34 years have decreased in the postvaccine era. However, there was no observed decrease in young males, while males aged 25-34 years experienced a slight decline in oropharyngeal squamous cell carcinoma. These findings suggest the potential early effects of HPV vaccination in the United States.
JNCI CANCER SPECTRUM
(2023)
