Article
Oncology
Hidde Swartjes, Nelleke P. M. Brouwer, Lindsey C. F. De Nes, Felice N. Van Erning, Rob H. A. Verhoeven, Pauline A. J. Vissers, Johannes H. W. De Wilt
Summary: The incidence of early-onset colorectal cancer is increasing annually in the Netherlands, while CRC incidence for 50-59 year olds showed a significant increase after nationwide screening in 2014. Patients with early-onset CRC received multimodal treatment more often than 50-59 year olds, with little difference in relative survival between the two groups.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Rafael Cardoso, Feng Guo, Thomas Heisser, Monika Hackl, Petra Ihle, Harlinde De Schutter, Nancy Van Damme, Zdravka Valerianova, Trajan Atanasov, Ondrej Majek, Jan Muzik, Mef Christina Nilbert, Anne Julie Tybjerg, Kaire Innos, Margit Magi, Nea Malila, Anne-Marie Bouvier, Veronique Bouvier, Guy Launoy, Anne-Sophie Woronoff, Melanie Cariou, Michel Robaszkiewicz, Patricia Delafosse, Florence Poncet, Alexander Katalinic, Paul M. Walsh, Carlo Senore, Stefano Rosso, Ieva Vincerzevskiene, Valery E. P. P. Lemmens, Marloes A. G. Elferink, Tom Borge Johannesen, Hartwig Korner, Frank Pfeffer, Maria Jose Bento, Jessica Rodrigues, Filipa Alves da Costa, Ana Miranda, Vesna Zadnik, Tina Zagar, Arantza Lopez de Munain Marques, Rafael Marcos-Gragera, Montse Puigdemont, Jaume Galceran, Maria Carulla, Maria-Dolores Chirlaque, Monica Ballesta, Kristina Sundquist, Jan Sundquist, Marco Weber, Andrea Jordan, Christian Herrmann, Mohsen Mousavi, Anton Ryzhov, Michael Hoffmeister, Hermann Brenner
Summary: There are diverse trends in colorectal cancer incidence, mortality, and stage distribution across European countries, mainly due to variations in the implementation of colorectal cancer screening programs.
Article
Oncology
Na Li, Bin Lu, Chenyu Luo, Jie Cai, Ming Lu, Yuhan Zhang, Hongda Chen, Min Dai
Summary: This review examines the status and trends of CRC in China, Europe, and northern America, discussing preventive strategies and screening techniques. While some European and northern American countries have seen decreases in CRC incidence and mortality, China continues to experience increasing rates.
Review
Gastroenterology & Hepatology
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
Summary: In the era of widespread uptake of screening colonoscopy, CRC incidence rates decreased by up to 50% in older age groups in the USA, despite adverse trends in CRC risk factors and increasing CRC incidence at younger ages. However, first results from a randomized trial suggest rather modest effects of screening colonoscopy. The apparent discrepancy between real-world and trial evidence can be explained by factors such as limited screening adherence, widespread uptake of colonoscopy outside the screening offers, and the inclusion of prevalent, non-preventable CRC cases in reported numbers of incident cases. Alternative interpretations of screening endoscopy trial results accounting for prevalence bias are in line with trends in countries offering CRC screening, and should encourage more widespread implementation and uptake of effective CRC screening.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Esther Toes-Zoutendijk, Geraldine Vink, Iris D. Nagtegaal, Manon C. W. Spaander, Evelien Dekker, Monique E. van Leerdam, Sabine Siesling, Iris Lansdorp-Vogelaar, Marloes A. G. Elferink
Summary: This study assessed the impact of the COVID-19 pandemic on colorectal cancer (CRC) incidence and stage distribution in the Netherlands. The findings showed a significant decrease in CRC incidence during the pandemic, particularly for stage I tumors. However, after gradually resuming screening, the number of CRC diagnoses increased.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Chelsea Herbert, Alessandro Paro, Adrian Diaz, Timothy M. Pawlik
Summary: The study found that county-level socioeconomic and healthcare factors were associated with breast and colorectal cancer outcomes, with the level of community distress impacting cancer screening, incidence, and mortality rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Holli A. Loomans-Kropp, Paul Pinsky, Asad Umar
Summary: The study found that aspirin use was not associated with a reduced risk of developing breast, bladder, esophageal, gastric, pancreatic, or uterine cancers in older individuals. However, it was linked to improved survival in bladder and breast cancer patients.
Article
Medicine, General & Internal
Matteo Rottoli, Alice Gori, Gianluca Pellino, Maria Elena Flacco, Cecilia Martellucci, Antonino Spinelli, Gilberto Poggioli
Summary: This study found a significant association between the SARS-CoV-2 pandemic and more advanced oncologic stage at diagnosis among patients with colorectal cancer, which may indicate a potential reduction in survival for these patients.
Article
Gastroenterology & Hepatology
Myrtle F. Krul, Marloes A. G. Elferink, Niels F. M. Kok, Evelien Dekker, Iris Lansdorp-Vogelaar, Gerrit A. Meijer, Iris D. Nagtegaal, Emilie C. H. Breekveldt, Theo J. M. Ruers, Monique E. van Leerdam, Koert F. D. Kuhlmann
Summary: The nationwide CRC screening program in the Netherlands, started in 2014, has shown a significant reduction in the incidence of stage II and IV CRC. Patients with screen-detected CRCs had improved survival and less extensive disease compared to clinically detected cases.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Yeshwanth Reddy Vedire, Sarbajit Mukherjee, Sumedha Dondapati, Sai Yendamuri
Summary: This study aimed to investigate the association between visceral obesity and disease recurrence and survival in early-stage colorectal cancer (CRC) patients. The researchers also examined if this association is influenced by metformin use. The results showed that visceral obesity, but not BMI, is associated with recurrence risk and poorer survival in stage I/II CRC. Interestingly, this association is influenced by metformin use.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Gastroenterology & Hepatology
Arthur Kooyker, Lucie de Jonge, Esther Toes-Zoutendijk, Manon Spaander, Hanneke van Vuuren, Ernst Kuipers, Folkert van Kemenade, Chris Ramakers, Evelien Dekker, Iris Nagtegaal, Monique van Leerdam, Iris Lansdorp-Vogelaar
Summary: FIT-based screening is effective in detecting early-stage colorectal cancer, and this effectiveness is maintained even with repeat screening. Increasing the FIT cut-off value significantly reduces the number of detected cancers, but the majority of detected cancers are still diagnosed at an early stage.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Mu Li, Eduardo A. Vega, Sebastian Mellado, Omid Salehi, Olga Kozyreva, Claudius Conrad
Summary: The incidence of very early onset colorectal cancer (EOCRC) has increased, particularly among White and Hispanic populations, as well as in counties with high poverty, unemployment, language barrier, foreign-born residents, and high school dropout rates. Minority and low-income patients have worse outcomes in terms of cancer-specific survival (CSS). Living in high poverty counties is an independent risk factor for poorer CSS in very early EOCRC.
SURGICAL ONCOLOGY-OXFORD
(2023)
Article
Oncology
Kenechukwu Chudy-Onwugaje, Wen-Yi Huang, L. Joseph Su, Mark P. Purdue, Christine C. Johnson, Lingxiao Wang, Hormuzd A. Katki, Kathryn Hughes Barry, Sonja I. Berndt
Summary: In this study, a beneficial role for both aspirin and ibuprofen in preventing advanced adenoma and curbing progression to recurrence and cancer among older adults was observed during long-term follow-up.
Article
Health Care Sciences & Services
Ania Gorostiza, Arantzazu Arrospide, Igor Larranaga, Aitziber Barandiaran, Adolfo Ruiz de Austri, Oliver Ibarrondo, Javier Mar
Summary: The study evaluated the effectiveness of an integrated care program for heart failure in the Basque Country, finding that intervention intensity is a key factor affecting the program's effectiveness. Differences between IHOs partially stem from the intensity of implementation. There is gender inequity in the implementation of the program, with women receiving lower intensity of intervention.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2021)
Article
Health Care Sciences & Services
Oliver Ibarrondo, Garbine Lizeaga, Jose Miguel Martinez-Llorente, Igor Larranaga, Myriam Soto-Gordoa, Isabel Alvarez-Lopez
Summary: This study quantitatively demonstrates the economic burden of different stages of breast, prostate, colorectal, and lung cancers, highlighting the impact on the healthcare system. Surgery and chemotherapy were found to be the most significant cost components.
Article
Nutrition & Dietetics
Maria Encarnacion Andreu-Reinon, Maria Dolores Chirlaque, Diana Gavrila, Pilar Amiano, Javier Mar, Mikel Tainta, Eva Ardanaz, Rosa Larumbe, Sandra M. Colorado-Yohar, Fernando Navarro-Mateu, Carmen Navarro, Jose Maria Huerta
Summary: The Mediterranean diet is associated with a reduced risk of dementia, especially in women and participants with lower education levels. The results varied by dementia sub-type, gender, and education, but there was no significant evidence of effect modification.
Article
Health Care Sciences & Services
Igor Larranaga, Inigo Etxebarria-Foronda, Oliver Ibarrondo, Ania Gorostiza, Cristina Ojeda-Thies, Jose Miguel Martinez-Llorente
Summary: This study conducted a cost-utility analysis of total versus partial hip arthroplasty in patients with femoral neck fractures. The results showed that the choice of surgical procedure depended on the patient's age and ASA risk class, with total hip arthroplasty being cost-effective for patients under 80 years old and hemiarthroplasty being cost-effective for ASA class I-II patients.
Article
Psychiatry
Javier Mar, Ania Gorostiza, Arantzazu Arrospide, Igor Larranaga, Ane Alberdi, Carlos Cernuda, Alvaro Iruin, Mikel Tainta, Lorea Mar-Barrutia, Oliver Ibarrondo
Summary: This study aimed to estimate the population incidence and prevalence of dementia and neuropsychiatric symptoms (NPS). The results showed that depressive and psychotic symptoms were common in the elderly population, with depressive symptoms being associated with dementia diagnosis time, living in a nursing home, and female gender, while psychotic symptoms were associated with male gender and older age.
REVISTA DE PSIQUIATRIA Y SALUD MENTAL
(2022)
Article
Health Care Sciences & Services
Arantzazu Arrospide, Oliver Ibarrondo, Ivan Castilla, Igor Larranaga, Javier Mar
Summary: This study described the development and validation of an obesity model which simulated cardiovascular risks associated with different BMI categories to evaluate the epidemiological and economic impact of obesity population policies. The model demonstrated the potential to reduce cardiovascular events and improve quality-adjusted life-years through simulations.
MEDICAL DECISION MAKING
(2022)
Article
Neurosciences
Oliver Ibarrondo, Jose Maria Huerta, Pilar Amiano, Maria Encarnacion Andreu-Reinon, Olatz Mokoroa, Eva Ardanaz, Rosa Larumbe, Sandra M. Colorado-Yohar, Fernando Navarro-Mateu, Maria Dolores Chirlaque, Javier Mar
Summary: This study developed and validated competing risk models to predict the late risk of dementia based on variables assessed in middle age in a southern European population. The study found that the AUC of the model for over-55-year-olds was much higher than the overall AUC in the first 15 years of follow-up and remained that way in the subsequent follow-up. The weight of the competing risk of death was greater than that of dementia, especially when the entire population was included.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Infectious Diseases
Lorea Arteche-Eguizabal, Inigo Corcuera-Martinez de Tobillas, Federico Melgosa-Latorre, Saioa Domingo-Echaburu, Ainhoa Urrutia-Losada, Amaia Eguiluz-Pinedo, Natalia Vanina Rodriguez-Piacenza, Oliver Ibarrondo-Olaguenaga
Summary: This study evaluated the adequacy of antibiotic treatment for community-acquired pneumonia in patients at a Spanish hospital. The results showed the highest agreement among departments in terms of antibiotic indication, time of first dose administration, and monitoring of efficacy and adverse effects. However, there were areas of disagreement regarding antibiotic choice, de-escalation/sequential therapy, treatment duration, and medical record documentation.
Article
Psychiatry
Javier Mar, Igor Larranaga, Oliver Ibarrondo, Ana Gonzalez-Pinto, Carlota las Hayas, Ane Fullaondo, Irantzu Izco-Basurko, Jordi Alonso, Inaki Zorrilla, Gemma Vilagut, Maider Mateo-Abad, Esteban de Manuel
Summary: The purpose of this study was to estimate the incidence and age of onset of mental disorders in children, adolescents, and young adults in the whole population of the Basque Country. The study found that the incidence of mental disorders was high, with marked differences by gender and socioeconomic status (SES). Males had higher incidence rates of ADHD, conduct disorders, depression, psychosis/personality disorders, and substance use, while females had higher rates of anxiety, eating disorders, and self-harm.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Renata Linertova, Carmen Guirado-Fuentes, Javier Mar-Medina, Conor Teljeur
Summary: This study estimated the costs and benefits of HPV vaccination in Spain, comparing two types of vaccine, only in girls or in both genders. The analysis considered both direct and indirect protection provided by vaccination. The results suggest that vaccinating all adolescents may not be cost-effective, but including protection against additional cancers or reducing the vaccine price would make it worth vaccinating all adolescents in Spain. The study also highlighted ethical arguments supporting HPV vaccination for both genders.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Psychiatry
Javier Mar, Igor Larranaga, Oliver Ibarrondo, Ana Gonzalez-Pinto, Carlota las Hayas, Ane Fullaondo, Irantzu Izco-Basurko, Jordi Alonso, Inaki B. Zorrilla, Jessica Fernandez-Sevillano, Esteban de Manuel
Summary: This study used a simulation model to evaluate the cost-effectiveness of a school-based intervention in promoting resilience and mental health in adolescence. The intervention was found to be economically advantageous from a societal perspective and more cost-effective in the most deprived group.
Article
Mathematical & Computational Biology
Nico Stollenwerk, Carlo Delfin S. Estradilla, Javier Mar, Joseba Bidaurrazaga Van-Dierdonck, Oliver Ibarrondo, Ruben Blasco-Agaudo, Maira Aguiar
Summary: Vaccine efficacy is not static and requires long-term population studies to evaluate its performance. COVID-19 vaccines have shown high effectiveness against severe disease and infection. A study in the Basque Country, Spain, using a model evaluated the impact of different vaccine types and observed a reduction in hospitalized COVID-19 cases after five months of vaccine rollout.
INFECTIOUS DISEASE MODELLING
(2023)
Article
Mathematics, Applied
Nico Stollenwerk, Stefano Spaziani, Javier Mar, Irati Eguiguren Arrizabalaga, Damian Knopoff, Nicole Cusimano, Vizda Anam, Akhil Shrivastava, Maira Aguiar
Summary: This study investigates models to describe respiratory diseases caused by fast mutating virus pathogens, which lead to the loss of acquired resistance in hosts after some years and the infection with new variants of the pathogen. Such models are important for understanding the seasonality and complex dynamics of respiratory diseases, and may also contribute to understanding the ongoing COVID-19 pandemic with emerging new variants and limited vaccine efficacies.
COMPUTATIONAL AND MATHEMATICAL METHODS
(2022)
Article
Biochemistry & Molecular Biology
Arantxa Acera, Juan Carlos Gomez-Esteban, Ane Murueta-Goyena, Marta Galdos, Mikel Azkargorta, Felix Elortza, Noelia Ruzafa, Oliver Ibarrondo, Xandra Pereiro, Elena Vecino
Summary: In this study, tear proteome analysis was used to identify proteins related to neurodegeneration in Parkinson's disease (PD). The findings suggest that lysosomal function plays a role in the pathophysiology of PD and may be associated with aggressive disease phenotype in PD patients.
