Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yen-Tze Liu, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Platyphyllenone can induce both autophagy and apoptosis in oral cancer cells by regulating multiple signaling pathways, providing a potential therapeutic option for chemoprevention against oral cancer proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Zhenzhen Chen, Tiankun Lu, Lan Huang, Zhiwei Wang, Zhongyi Yan, Yubo Guan, Wenjing Hu, Zusen Fan, Pingping Zhu
Summary: The study uncovers the role of the circular RNA cia-MAF in regulating liver tumor-initiating cells by affecting the expression of MAFF to modulate the growth and metastasis of liver TICs. MAFF is highly expressed in liver tumors and liver TICs, and its inhibitor shows therapeutic potential, especially for liver cancer without MAFA/MAFG gene copy number alterations.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Veterinary Sciences
Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutani
Summary: The study revealed that African hedgehog adenovirus uses the p38 pathway for replication in infected cells and induces cytopathic effects. Inhibitors of the p38 pathway were effective in suppressing viral replication, but did not inhibit virus-induced cytopathic effects.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Physiology
Keigo Machida
Summary: This article reviews the links between HCV-associated HCC and TICs, discussing how HCV promotes the genesis of TICs and the development of HCC, and how this process can be utilized as a novel therapeutic target for HCC treatment. Additionally, it introduces the ten hall marks of TIC oncogenesis and HCC development as targets for novel therapeutic modalities.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yuping Wang, Xiaoji Luo, Jinyong Luo
Summary: The study demonstrates that Cardamonin inhibits proliferation, migration, and invasion of osteosarcoma cells, inducing cell cycle arrest. It has minimal effects on normal cells and represses tumor growth in a xenograft mouse model. Mechanistically, Cardamonin activates the P38 and JNK MAPK signaling pathway to promote apoptosis in osteosarcoma cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Article
Biochemistry & Molecular Biology
Yang Gu, Yanying Wang, Luyun He, Jiahang Zhang, Xiaoxiao Zhu, Nian Liu, Jianyi Wang, Tiankun Lu, Lei He, Yong Tian, Zusen Fan
Summary: This study identified circIPO11 as highly expressed in HCC tumor tissues and liver CSCs, playing a critical role in self-renewal maintenance of liver CSCs and HCC development. Mechanistically, circIPO11 activates the Hedgehog signaling pathway, promoting tumor cell propagation. Targeting circIPO11 and the Hedgehog pathway may provide new potential for HCC treatment.
Article
Neurosciences
Xiaokun Zhou, Wenxiang Yi, Yiqiang Zhi, Jurui Yu, Danping Lu, Zhousong Luo, Ling Yuan, Liyu Chen, Zhiheng Xu, Dan Xu
Summary: Stress is considered a major cause of depression, and recent studies have linked JNK kinase activity to depression. We conducted a study on transgenic mice and found that excessive activation of JNK directly leads to depression-like behavior in mice, accompanied by reduced expression of synaptic-associated genes and abnormal dendritic spine development in hippocampal neurons. These findings provide compelling evidence for targeting JNK activity as a potential therapeutic strategy for depression.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Article
Food Science & Technology
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Jong-Choon Kim, Je-Won Ko, Tae-Won Kim
Summary: In this study, the protective effects of DADS against 1,3-DCP-induced hepatotoxicity and oxidative damage were investigated. The results showed that DADS treatment inhibited the increase in serum aminotransferase levels and reduced histopathological alterations in the liver induced by 1,3-DCP. Additionally, DADS treatment reduced 1,3-DCP-induced apoptotic changes in the liver and inhibited phosphorylation of MAPKs. These protective effects may be related to the inhibition of CYP2E1 expression, enhancement of antioxidant enzyme activity, and reduction of apoptotic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ting-Ting Zhang, Qing-Qing Lei, Jie He, Xin Guan, Xin Zhang, Ying Huang, Zi-Yue Zhou, Rui-Xin Fan, Ting Wang, Chen-Xi Li, Jin-Yan Shang, Zhuo-Miao Lin, Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong, Jing-Song Ou, Rui-Ping Pang, Xiao-Ping Fan, Hui Huang, Jia-Guo Zhou
Summary: This study reveals that Best3 mutation, which mainly acts in blood vessels, leads to aortic dissection by regulating the degradation of MEKK2/3, controlling smooth muscle cell phenotypic switch, and maintaining the structural integrity of the aorta. This provides a new therapeutic target for the treatment of aortic dissection.
Article
Biotechnology & Applied Microbiology
Yu-Hsuan Fu, Da-Liang Ou, Yi-Ru Yang, Kuan-Wei Su, Chien-Yuan Chen, Hwei-Fan Tien, Zheng-Sheng Lai, Che-Kun James Shen, Hsiung-Fei Chien, Liang-In Lin
Summary: Cabozantinib promotes erythroid differentiation in leukemia cells through upregulating heme biosynthesis, hemoglobin production, and erythroid-associated pathways, while inhibiting cell proliferation by downregulating cell survival pathways.
CANCER GENE THERAPY
(2022)