Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Polymer Science
Meimei Guo, Zhihua Zhou, Wenjuan Liu, Tianlong Huang, Wei Wu, Jianglong Duan, Meiling Yi, Chao Zhang, Xiao He, Jinxing Chen, Jiaming Gu, Jianjun Fang
Summary: This paper introduces a novel degradable scaffold material for bone tissue repairing, which is prepared by combining polymer with bioceramic. The composite scaffolds showed good pore structure and compressive strength. The results suggest that the composite scaffolds have potential for application in bone tissue regeneration.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2022)
Article
Materials Science, Composites
He Cai, Tongrui Zhang, Ruixian Dai, Shiping Song, Rui Han, Yijun Li, Junyu Chen
Summary: In this study, a PLGA/PCL bone fixation plate with enhanced mechanical and cell adhesion properties was produced by micro-injection process. The in-situ fibrillation of PCL at high injection rate constructed unique parent-daughter fibril morphology, promoting the interaction between PLGA and PCL interfaces. The well-oriented PCL fibrils with high crystallinity served as a barrier to prevent slip of PLGA molecular chain and water molecule invasion, playing a key role in promoting cell proliferation.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Jiaming Gu, Zhihua Zhou, Tianlong Huang, Wei Wu, Wenjuan Liu, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Chao Zhang, Meilin Yi, Xiao He, Jianjun Fang
Summary: Composite porous microspheres based on blends of PLGCL and BMPLGA were prepared using solvent evaporation and particle leaching technique. The microspheres showed porous surface and excellent cytocompatibility, indicating potential for drug delivery and tissue regeneration applications.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2022)
Article
Polymer Science
Yun Ou, Wei Wu, Zhihua Zhou
Summary: A novel type of composite scaffolds based on PLLGC, BMPLGA, NBAG and β-TCP was fabricated by using a TIPS method. The degradation rate of the composite scaffolds decreased due to the alkaline effect of NBAG and β-TCP particles, which neutralized acidic polymeric degradation products and bound H+ ions from tissue fluids.
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
(2022)
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Materials Science, Multidisciplinary
Fanny Bonnet, Bernard Miranda Campos, Gaelle Fontaine, Serge Bourbigot, Gregory Stoclet
Summary: In this study, PLLA-based/glass fabric composites with poly(L-lactide-co-e-caprolactone) as the matrix were reported, displaying high wettability and toughness.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.
Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Pharmacology & Pharmacy
Nguyen Thi Thu Thao, Surha Lee, Gi Ru Shin, Youngji Kang, Sangdun Choi, Moon Suk Kim
Summary: Small intestine submucosa (SIS) was chosen as a drug carrier and electrospun into nanofiber sheets. Poly(epsilon-caprolactone-ran-l-lactide) (PCLA) copolymers were used to improve the electrospinning performance of SIS, resulting in adjustable S/P-NS with different porosities and tensile strengths. The electrospun S/P-NS successfully delivered dexamethasone (Dex) and silver sulfadiazine (AgS) for sustained release over three weeks, suppressing macrophage infiltration.
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Biotechnology & Applied Microbiology
Tiantang Fan, Jingwen Qin, Xiao Meng, Jiafeng Li, Qing Liu, Guannan Wang
Summary: PLPG membranes with sc-PLA improved the crystallizing behavior of PLLA segments, increased thermal stability and degradation ability, and showed low cytotoxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Luca Magazzini, Sara Grilli, Seif Eddine Fenni, Alessandro Donetti, Dario Cavallo, Orietta Monticelli
Summary: Poly(glycolic acid) (PGA) has unique properties including high gas barrier properties, tensile strength, resistance to solvents, heat distortion temperature, stiffness, and biodegradability; combining PGA with other bioplastics can reduce costs and introduce new properties while maintaining green features. The presence of PGA in blends affects thermal properties and degradation behavior, accelerating the hydrolysis process, particularly in PLLA-based systems.
