Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 85, Pages 12606-12609Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05959g
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Funding
- National Institute of Health [CA161158, GM102735]
- National Science Foundation [CHE-1148684, CHE-1112188, CHE-1306977, DGE-1144081]
- Welch Foundation [A-1715]
- Deutsche Forschungsgemeinschaft [SU 726/6-1 in SPP1623]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1148684] Funding Source: National Science Foundation
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Fluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.
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