Article
Immunology
Dmytro Shytikov, Deepak Rohila, Dan Li, Pengfei Wang, Mei Jiang, Mingxu Zhang, Qin Xu, Linrong Lu
Summary: The role of Ly49(+)CD8 T-cells in the immune system and the mechanism of Ly49 expression on CD8 T-cells are still unclear. Studies have shown that Ly49(+)CD8 T-cells express different receptors compared to NK cells and play important roles in immune response and viral infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert L. Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Eva Pascal, Killian Raes, Sarah Bonte, Tessa Kerre, Niels Vandamme, Ruth Seurinck, Jana Roels, Marieke Lavaert, Filip Van Nieuwerburgh, Georges Leclercq, Tom Taghon, Francis Impens, Bjorn Menten, David Vermijlen, Bart Vandekerckhove
Summary: Billiet et al. identify a well-defined but heterogeneous unconventional TCR alpha beta(+) lineage mainly confined to CD8(+) Helios(+) T cells, which represents the post-thymic progeny of CD10(+) PD-1(+) precursors in humans. These unconventional T cells (UTCs) in thymus and blood share a common developmental trajectory, characterized by hallmark transcription factors (ZNF683 and IKZF2) and a polycolonal TCR repertoire with autoreactive features. The UTC lineage can be identified in adult blood and intestinal tissues.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Xiaoqi Wei, Xiuhua Yang
Summary: Preeclampsia (PE) is a unique pregnancy-related disease that can cause maternal and perinatal mortality. Research suggests that natural killer (NK) cells play a central role in immune communication between the fetus and mother, and changes in their count or function may be the cause of PE. This review provides obstetricians with an updated report on the immunological roles of NK cells in PE and suggests that therapeutic measures targeting NK cells are necessary to maintain immune equilibrium.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jose Lourenco Reis, Natacha Nurdine Rosa, Miguel Angelo-Dias, Catarina Martins, Luis Miguel Borrego, Jorge Lima
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial cells outside the uterus. Studies indicate a correlation between the immune system, particularly NK receptors (NKR), and endometriosis, suggesting their essential role in the disease's pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Eleonora Russo, Mattia Laffranchi, Luana Tomaipitinca, Annalisa Del Prete, Angela Santoni, Silvano Sozzani, Giovanni Bernardini
Summary: NK cells, as innate lymphoid cells, play key roles in immune surveillance of tumors with cytotoxic capacity. Increasing evidence shows that NK cell anti-tumor response is influenced by bidirectional interactions with myeloid cell subsets such as dendritic cells and macrophages in the tumor microenvironment. This crosstalk can impact NK cell survival, activation, differentiation, and function, ultimately affecting the efficacy of immunotherapeutic approaches for cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Thessa Laeremans, Sabine den Roover, Cynthia Lungu, Sigrid D'haese, Rob A. A. Gruters, Sabine D. D. Allard, Joeri L. L. Aerts
Summary: This study evaluated the effects of a therapeutic DC-based vaccine consisting of monocyte-derived DCs electroporated with HIV-1 Tat, Rev and Nef encoding mRNA on NK cell frequency, phenotype and functionality in HIV-1-infected individuals. The results showed a significant increase in cytotoxic NK cells, changes in NK cell phenotype associated with migration and exhaustion, as well as improved NK cell-mediated killing and (poly)functionality following immunisation. These findings highlight the importance of evaluating NK cells in future clinical trials of DC-based immunotherapy in the context of HIV-1 infection.
Article
Immunology
Zhi Zhang, Ying Zhou, Jing Lu, Yuan-Fang Chen, Hai-Yang Hu, Xiao-Qin Xu, Geng-Feng Fu
Summary: This study compared the phenotypes of NK cells in subjects with chronic HIV-1 infection, HIV controllers, and healthy donors, showing that controllers had increased activating receptors expression and a higher number of CD56(+)/CD16(-) NK cell subset, along with higher levels of plasma cytokines. This suggests that higher immune activation in controllers may play a key role in killing and suppressing HIV compared to chronic patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hamid Shegarfi
Summary: The study focuses on the cellular immune responses in animal disease models, particularly the role of natural killer (NK) cells in the host-pathogen interaction with Listeria monocytogenes (LM) bacterium. The research reveals that NK cell ligands, including MHC class I molecules and Clr molecules, are influenced in LM-infected cells, leading to the stimulation of rat NK cells. These findings contribute to our understanding of how NK cells recognize and respond to LM infection.
Review
Immunology
Hakim Medjouel Khlifi, Sophie Guia, Eric Vivier, Emilie Narni-Mancinelli
Summary: NK cells are innate lymphoid cells that can directly kill tumor cells. They identify tumor cells through activating receptors and secrete cytokines and chemokines to shape the immune response. Targeting the activating receptors of NK cells has become an important strategy in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Rosa Molfetta, Sara Petillo, Marco Cippitelli, Rossella Paolini
Summary: SUMOylation is an important reversible modification that affects the function and stability of proteins. It has been discovered to play a role in the regulation of genomic stability and immune responses, particularly in natural killer (NK) cells. NK cells are innate immune cells that are crucial for host defense against viral infections and tumors. The expression of NK cell receptors and ligands on target cells is tightly regulated through post-translational modifications, including SUMOylation. This review focuses on the role of SUMOylation and related pathways in the biology of NK cells, with a special emphasis on their response against cancer. The potential use of selective inhibitors to enhance NK cell-mediated killing of tumor cells is also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Letter
Oncology
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu
Summary: This study identifies a four-stage developmental model for mouse NK cell development and defines two distinct populations of immature NK cells.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Idoia Mikelez-Alonso, Susana Magadan, Africa Gonzalez-Fernandez, Francisco Borrego
Summary: NK cells are lymphocytes with potent antitumor and antiviral functions, exhibiting memory-like responses. Various NK cell-based immunotherapies have been developed, with nanotechnology considered as an attractive option to enhance NK cell effector functions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Oncology
Dhanashree Murugan, Vasanth Murugesan, Balaji Panchapakesan, Loganathan Rangasamy
Summary: This paper reviews the role of natural killer (NK) cells in killing tumor cells and the receptors that can be targeted for signaling. It also highlights the potential of nanoparticles in activating NK cells and enhancing their cytotoxic activity against cancer.
Review
Cell Biology
Patricia Pascual-Vargas, Patricia C. Salinas
Summary: The Wnt pathway regulates the formation and function of neuronal circuits through Frizzled receptors, with aberrant signaling linked to synaptic defects and neurodegenerative diseases. The localization and stability of Fzd receptors are crucial for determining Wnt function, with post-translational modifications playing a key role. However, only phosphorylation and glycosylation have been studied as mechanisms for modulating Fzd function in the central nervous system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Sofia Carreira-Santos, Nelson Lopez-Sejas, Marina Gonzalez-Sanchez, Eva Sanchez-Hernandez, Alejandra Pera, Fakhri Hassouneh, Esther Duran, Rafael Solana, Javier G. Casado, Raquel Tarazona
Summary: This study provides a deep phenotypic characterization of in vitro-expanded CIML NK cells. Moreover, the correlations found between NK cell receptors and degranulation capacity of CIML NK cells allowed the identification of several biomarkers that could be useful in clinical settings.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Megan M. Tu, Mir Munir A. Rahim, Celine Sayed, Ahmad Bakur Mahmoud, Andrew P. Makrigiannis
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Dikchha Rijal, Ardeshir Ariana, Andrew Wight, Kwangsin Kim, Norah A. Alturki, Zoya Aamir, Emmanuelle S. Ametepe, Robert G. Korneluk, Christopher Tiedje, Manoj B. Menon, Matthias Gaestel, Scott McComb, Subash Sad
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Immunology
Andreas Margraf, Stephanie Volmering, Jennifer Skupski, Veerle Van Marck, Andrew P. Makrigiannis, Helena Block, Alexander Zarbock
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Andrew Wight, Ahmad Bakur Mahmoud, Michal Scur, Megan M. Tu, Mir Munir A. Rahim, Subash Sad, Andrew P. Makrigiannis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Immunology
Elias Abou-Samra, Zachary Hickey, Oscar A. Aguilar, Michal Scur, Ahmad Bakur Mahmoud, Sergey Pyatibrat, Megan M. Tu, Jeffrey Francispillai, Arthur Mortha, James R. Carlyle, Mir Munir A. Rahim, Andrew P. Makrigiannis
CELLULAR & MOLECULAR IMMUNOLOGY
(2019)
Article
Virology
Oscar A. Aguilar, Isabella S. Sampaio, Mir Munir A. Rahim, Jackeline D. Samaniego, Mulualem E. Tilahun, Mithunah Krishnamoorthy, Branka Popovic, Marina Babic, Astrid Krmpotic, Bebhinn Treanor, David H. Margulies, David S. J. Allan, Andrew P. Makrigiannis, Stipan Jonjic, James R. Carlyle
JOURNAL OF VIROLOGY
(2020)
Article
Virology
Mir Munir A. Rahim, Brendon D. Parsons, Emma L. Price, Patrick D. Slaine, Becca L. Chilvers, Gregory S. Seaton, Andrew Wight, Daniel Medina-Luna, Sayanti Dey, Shannen L. Grandy, Lauryn E. Anderson, Natalia Zamorano Cuervo, Nathalie Grandvaux, Marta M. Gaglia, Alyson A. Kelvin, Denys A. Khaperskyy, Craig McCormick, Andrew P. Makrigiannis
JOURNAL OF VIROLOGY
(2020)
Article
Multidisciplinary Sciences
Xianli Shen, Yiguo Qiu, Andrew E. Wight, Hye-Jung Kim, Harvey Cantor
Summary: Expression of CD11c and OPN marks a stable microglial subset in the brain, independent of environmental activation stimuli. OPN is required for subset stability and the execution of phagocytic and proinflammatory responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Pilar Baldominos, Alex Barbera-Mourelle, Olga Barreiro, Yu Huang, Andrew Wight, Jae-Won Cho, Xi Zhao, Guillem Estivill, Isam Adam, Xavier Sanchez, Shannon McCarthy, Julien Schaller, Zara Khan, Albert Ruzo, Ricardo Pastorello, Edward T. Richardson, Deborah Dillon, Paula Montero-Llopis, Romualdo Barroso-Sousa, Juliet Forman, Sachet A. Shukla, Sara M. Tolaney, Elizabeth A. Mittendorf, Ulrich H. von Andrian, Kai W. Wucherpfennig, Martin Hemberg, Judith Agudo
Summary: This study discovered that in primary breast cancer, tumor cells that resist T cell attack are quiescent and form clusters with reduced immune infiltration. These quiescent cancer cells show superior tumorigenic capacity and higher expression of chemotherapy resistance and stemness genes. Single-cell RNA sequencing revealed differential phenotypes in infiltrating cells based on their intra-tumor location, and uncovered hypoxia-induced immune-suppressive programs. The findings suggest that eliminating quiescent cancer cells holds the promise to counteract immunotherapy resistance and prevent disease recurrence in TNBC.
Article
Multidisciplinary Sciences
Andrew E. Wight, Jessica M. Sido, Sandrine Degryse, Lin Ao, Hidetoshi Nakagawa, Yiguo Qiu(Vivian), Xianli Shen, Oba Oseghali, Hye-Jung Kim, Harvey Cantor
Summary: Regulatory T cells (Treg) expressing interleukin 23 receptor (IL23R) promote suppressive activity, hindering antitumor immunity. Disrupting IL23R enhances Treg responsiveness to IL12, resulting in increased production of γ-interferon and recruitment of CD8 T cells that inhibit tumor growth. Combined targeting of destabilization pathways in Treg can lead to robust and synergistic antitumor responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Oscar A. Aguilar, Richard Berry, Mir Munir A. Rahim, Johanna J. Reichel, Branka Popovic, Miho Tanaka, Zhihui Fu, Gautham R. Balaji, Timothy N. H. Lau, Megan M. Tu, Christina L. Kirkham, Ahmad Bakur Mahmoud, Aruz Mesci, Astrid Krmpotic, David S. J. Allan, Andrew P. Makrigiannis, Stipan Jonjic, Jamie Rossjohn, James R. Carlyle