Article
Cardiac & Cardiovascular Systems
Miguel M. Leiva-Juarez, Luke Benvenuto, Joseph Costa, John W. Blackett, Meghan Aversa, Hilary Robbins, Lori Shah, Bryan P. Stanifer, Phillippe H. Lemaitre, Daniela Jodorkovsky, Selim Arcasoy, Joshua R. Sonett, Frank D'Ovidio
Summary: This study suggests that undergoing fundoplication after lung transplantation can improve posttransplant survival, especially for younger patients with restrictive diseases and those who receive single or double lung transplants. The method of diagnosing gastroesophageal reflux disease has different impacts on outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Article
Respiratory System
Rayoun Ramendra, Juan C. Fernandez-Castillo, Ella Huszti, Rasheed Ghany, Meghan Aversa, Jan Havlin, Peter Riddell, Cecilia M. Chaparro, Lianne G. Singer, Louis Liu, Shaf Keshavjee, Jonathan C. Yeung, Tereza Martinu
Summary: Esophageal motility disorders, specifically oesophagogastric junction outflow obstruction (OGJOO) and major disorders of peristalsis, are associated with an increased risk of chronic lung allograft dysfunction (CLAD) and allograft failure in lung transplant recipients. These findings have implications for risk stratification and personalized treatment for aspiration prevention in this population.
Article
Pediatrics
Charlotte Flatres, Madeleine Aumar, Delphine Ley, Rony Sfeir, Audrey Nicolas, Michel Bonnevalle, Alain Duhamel, Frederic Gottrand
Summary: This study demonstrates a high prevalence of acid gastroesophageal reflux disease (GERD) in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with proton pump inhibitors (PPI) is stopped.
PEDIATRIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Annelies Geeraerts, Livia Guadagnoli, Ans Pauwels, Hannelore Geysen, Thomas Neyens, Lukas Van Oudenhove, Tim Vanuytsel, Jan Tack
Summary: This study aimed to investigate the association between psychological symptoms and reflux phenotype along the GERD spectrum in refractory reflux patients. The findings suggest that psychological symptoms do not differ across reflux phenotypes and do not predict reflux phenotype membership in refractory reflux patients.
Article
Pediatrics
Marinde van Lennep, Frederique Lansink, Marc A. Benninga, Michiel P. van Wijk
Summary: The study aimed to determine age-specific normal values in healthy infants using the Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R). The results showed that reflux symptoms decrease in the first 24 months of life in healthy infants. Validation as a diagnostic tool for GER-disease using age-appropriate normal values is needed.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Pierre H. H. Schneeberger, Chen Yang Kevin Zhang, Jessica Santilli, Bo Chen, Wei Xu, Youngho Lee, Zonelle Wijesinha, Elaine Reguera-Nunez, Noelle Yee, Musawir Ahmed, Kristen Boonstra, Rayoun Ramendra, Courtney W. Frankel, Scott M. Palmer, Jamie L. Todd, Tereza Martinu, Bryan Coburn
Summary: This study compares the allograft microbiota in lung transplant recipients with or without clinically diagnosed GERD in the first year after transplant. The study finds that GERD is associated with high bacterial density and specific bacterial genera. Microbial community types associated with high bacterial density are related to inflammation and early development of ALAD and CLAD. Nissen fundoplication surgery can reduce microbial density and proinflammatory cytokines.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Gaia Pellegatta, Benedetto Mangiavillano, Rossella Semeraro, Francesco Auriemma, Elisa Carlani, Alessandro Fugazza, Edoardo Vespa, Alessandro Repici
Summary: Extraesophageal reflux symptoms are common in the Western population and their clinical management is controversial. This study evaluated a new treatment method for patients with GERD experiencing extraesophageal symptoms. The results showed that the treatment method reduced symptom frequency and severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Shouli Wang, Junliang Kuang, Hongwei Zhang, Wenlian Chen, Xiaojiao Zheng, Jieyi Wang, Fengjie Huang, Kun Ge, Mengci Li, Mingliang Zhao, Cynthia Rajani, Jinshui Zhu, Aihua Zhao, Wei Jia
Summary: This study explores the roles of refluxed bile acids (BAs) and microbiome in gastric carcinogenesis. The results show that certain bile acids and bacteria abundance are increased significantly in the gastric juice of patients with bile reflux gastritis (BRG) and gastric cancer (GC). It is found that taurodeoxycholic acid (TDCA) promotes gastric cell proliferation through the IL-6/JAK1/STAT3 pathway. Mouse models further validate these findings and demonstrate that bile reflux-induced gastric precancerous lesions can be prevented by using a STAT3 inhibitor.
Review
Gastroenterology & Hepatology
Suzanna Hirsch, Rachel Rosen
Summary: Gastroesophageal reflux (GER) is a common complaint in pediatric gastroenterology, and both typical and atypical GER can cause various symptoms in children. While traditional diagnosis and treatment focus on acid, the importance of nonacid reflux in both children and adults is being recognized. This review examines the role of nonacid reflux in pediatric patients, including definitions, symptom associations, pathophysiologic mechanisms, and treatment implications.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Inyoung Hwang, Sang Chun Ji, Jaeseong Oh, Hyojin Kim, Hyunju Cha, John Kim, Chang-Seok Lee, Kyung-Sang Yu, SeungHwan Lee
Summary: This study investigated the safety, tolerability, pharmacodynamics, pharmacokinetics, and pharmacogenomics of zastaprazan. The results showed that zastaprazan effectively suppressed gastric acid secretion and exhibited favorable pharmacokinetic properties. The evaluation indicated that zastaprazan is safe and suitable for the treatment of acid-related diseases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Surgery
Deepika Razia, Sumeet K. Mittal, Rajat Walia, Sofya Tokman, Jasmine L. Huang, Michael A. Smith, Ross M. Bremner
Summary: This study compared the 30-day readmission rate and short-term morbidity after laparoscopic antireflux surgery (LARS) between lung transplant recipients and matched nontransplant controls. The results showed that lung transplant recipients had a higher 30-day readmission rate but similar short-term morbidity compared to the nontransplant controls. The study suggests that LARS after lung transplantation is safe in a large-volume center with expertise in transplant and foregut surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Respiratory System
Samantha E. Halpern, Aryaman Gupta, Oliver K. Jawitz, Ashley Y. Choi, Hai Salfity, Jacob A. Klapper, Matthew G. Hartwig
Summary: The study investigated the safety of using the LINX device for GERD treatment after lung transplantation, and found that patients showed improvement in acid testing and medication use after the procedure, although experienced more early side effects.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Gastroenterology & Hepatology
Chamara Basnayake, Annelies Geeraerts, Ans Pauwels, Ger Koek, Michael Vaezi, Tim Vanuytsel, Jan Tack
Summary: The prevalence of duodenogastroesophageal reflux (DGER) increases with more advanced esophageal lesions in patients with gastroesophageal reflux disease (GERD) and persists in patients on proton pump inhibitor (PPI) therapy. PPIs appear to be effective in treating DGER, but further research is needed for future therapies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Physiology
Menglei Wang, Enzhe Lou, Zengfu Xue
Summary: Intestinal metaplasia (IM), a precancerous lesion of gastric cancer (GC), is the transformation of non-intestinal epithelium into intestinal-like mucosa. It greatly increases the risk of developing the intestinal type of GC, commonly found in the stomach and esophagus. Recent studies have confirmed that bile acids (BAs), present in gastric and duodenal contents, play a role in the occurrence and development of IM and Barrett's esophagus (BE). This review aims to discuss the mechanism of IM induced by bile acids, providing a foundation for improving current management strategies for BE and IM.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Surgery
Julia R. Amundson, Haris Zukancic, Kristine Kuchta, Christopher J. Zimmermann, Vanessa N. VanDruff, Stephanie Joseph, Simon Che, Shun Ishii, H. Mason Hedberg, Michael B. Ujiki
Summary: This study reviewed the outcomes of patients undergoing anti-reflux surgery (ARS) based on different criteria for the diagnosis of GERD. The study found that the updated AGA criteria exclude a portion of patients who would have been diagnosed with and surgically treated for GERD. However, the outcomes of these excluded patients were not inferior to those who met the traditional criteria.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Cardiac & Cardiovascular Systems
Cynthia L. Green, Brian C. Gulack, Shaf Keshavjee, Lianne G. Singer, Kenneth McCurry, Marie M. Budev, Tammy L. Reece, Anne O. Lidor, Scott M. Palmer, R. Duane Davis
Summary: A multicenter retrospective study found limited benefits of fundoplication for preventing bronchiolitis obliterans syndrome and improving survival compared to reflux disease without surgery after lung transplantation. However, the study had limitations in terms of sample size, follow-up duration, and potential selection bias, highlighting the need for a randomized, prospective study.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Carmen Lefaucheur, Kevin Louis, Anna B. Morris, Jean-Luc Taupin, Peter Nickerson, Anat R. Tambur, Howard M. Gebel, Elaine F. Reed
Summary: This consensus report provides clinical practice recommendations in kidney, heart, lung, and liver transplantation based on expert assessment of quality and strength of evidence regarding the relationship between anti-HLA donor-specific antibodies and transplant outcome. The recommendations address major clinical problems in transplantation, including the clinical implications of positive posttransplant DSA detection, the relevance of posttransplant DSA assessment for diagnosis and treatment management, and the relevance of posttransplant DSA for allograft prognosis and risk stratification.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Aparna C. Swaminathan, Alec McConnell, Sarah Peskoe, Mustafa R. Bashir, Erika Bush Buckley, Courtney W. Frankel, Daniel J. Turner, Patrick J. Smith, Lorenzo Zaf, Lianne G. Singer, Laurie D. Snyder
Summary: This study investigated the relationship between multiple frailty models before lung transplantation and short-term outcomes after surgery. It found that cumulative deficit models of frailty were associated with outcomes within the first 90 days, while phenotypic frailty was associated with 1-year survival.
Correction
Cardiac & Cardiovascular Systems
Emily S. Clausen, Jeremy M. Weber, Megan L. Neely, Kathleen J. Ramos, Laurie D. Snyder
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jamie L. Todd, Jeremy M. Weber, Francine L. Kelly, Megan L. Neely, Andrew Nagler, Dylan Carmack, Courtney W. Frankel, David M. Brass, John A. Belperio, Marie M. Budev, Matthew G. Hartwig, Tereza Martinu, John M. Reynolds, Pali D. Shah, Lianne G. Singer, Laurie D. Snyder, S. Sam Weigt, Scott M. Palmer
Summary: This study found an association between reduced levels of club cell secretory protein (CCSP) in bronchoalveolar lavage fluid (BALF) and the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. Decreased CCSP in early post-transplant BALF may indicate an increased risk of later CLAD.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Liran Levy, Sajad Moshkelgosha, Ella Huszti, Sarah Hunter, Benjamin Renaud-Picard, Gregory Berra, Mitsuaki Kawashima, Juan Fernandez-Castillo, Eyal Fuchs, Milagros Dianti, Rasheed Ghany, Shaf Keshavjee, Lianne G. Singer, Jussi Tikkanen, Tereza Martinu
Summary: This study found that markers of epithelial activity and injury in bronchoalveolar lavage fluid (BAL) are associated with the diagnosis of chronic lung allograft dysfunction (CLAD) and different phenotypes of CLAD. The abnormal expression of airway mucins and epithelial cell death may be involved in the pathogenesis of CLAD, and their detection could assist in the development of targeted therapies.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Virology
Lorenzo Zaffiri, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, Micah A. Luftig
Summary: Reactivation of Epstein-Barr virus (EBV) is often seen in lung transplant recipients (LTRs), but the cellular immune responses to EBV in adult LTRs have not been fully described. In this study, we found significant changes in CD4/CD8 ratio, EBV-specific CD8(+)CD69(+) T cell responses, and NK cell phenotypic changes in adult LTRs with EBV-associated diseases. These findings provide valuable insights into the immune responses to EBV in adult LTRs and may contribute to improved management of EBV-related complications.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Critical Care Medicine
Aparna C. Swaminathan, Laurie D. Snyder, Hwanhee Hong, Susanna R. Stevens, Alexander S. Long, Eric Yanchenko, Ying Qiu, Rong Liu, Hongtao Zhang, Aryeh Fischer, Leah Burns, Lisa M. Wruck, Scott M. Palmer
Summary: This study aimed to develop IPF ECs using fit-for-purpose data standards and evaluate their endpoint comparability with the BMS-986020 phase II RCT. The results showed that IPF ECs generated from historical RCT placebo arms had comparable primary treatment effects to that of the original clinical trial, while ECs from real-world data sources did not.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Andrew T. Sage, Laura L. Donahoe, Alaa A. Shamandy, S. Hossein Mousavi, Bonnie T. Chao, Xuanzi Zhou, Jerome Valero, Sharaniyaa Balachandran, Aadil Ali, Tereza Martinu, George Tomlinson, Lorenzo Del Sorbo, Jonathan C. Yeung, Mingyao Liu, Marcelo Cypel, Bo Wang, Shaf Keshavjee
Summary: In this study, authors developed a machine learning model called InsighTx, which accurately predicts transplant outcomes and increases organ utilization rates. Training and test datasets showed that InsighTx model achieved a high AUROC in predicting transplant outcomes. Implementation study also demonstrated that InsighTx increased the likelihood of transplanting suitable donor lungs and decreased the likelihood of transplanting unsuitable donor lungs.
NATURE COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Omar Al-Qudsi, John M. Reynolds, John C. Haney, Ian J. Welsby
Summary: Hypoxia is a common issue in the ICU, occurring due to various pathological characteristics. The oxygen-hemoglobin dissociation curve explains the affinity between hemoglobin and PO2, as well as factors affecting oxygen uptake and release. Limited research exists on manipulating the hemoglobin-oxygen relationship. Voxelotor, a hemoglobin oxygen-affinity modulator approved by the FDA, was used to assist with chronic hypoxia and weaning off mechanical support in two non-sickle cell disease patients.
Meeting Abstract
Cardiac & Cardiovascular Systems
W. M. Tsuang, Ml Neely, S. M. Palmer, LG. Singer, M. Budev, P. Shah, J. A. Belperio, J. M. Reynolds, L. D. Snyder
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Joao A. de Andrade, Megan L. Neely, Anne S. Hellkamp, Daniel A. Culver, Hyun J. Kim, Timothy Liesching, Leonard J. Lobo, Murali Ramaswamy, Zeenat Safdar, Shaun Bender, Craig S. Conoscenti, Thomas B. Leonard, Scott M. Palmer, Laurie D. Snyder
Summary: This study investigated the impact of antifibrotic therapy on mortality and other outcomes in patients with idiopathic pulmonary fibrosis (IPF) using causal inference methodology. The results suggest that patients with IPF who receive antifibrotic therapy have improved survival but may also have increased risks of respiratory-related hospitalizations and acute worsening of IPF.
CLINICAL THERAPEUTICS
(2023)
Article
Respiratory System
Todd L. L. Astor, Hilary J. J. Goldberg, Laurie D. D. Snyder, Andrew Courtwright, Ramsey Hachem, Tahuanty Pena, Lorenzo Zaffiri, Gerard J. J. Criner, Marie M. M. Budev, Tany Thaniyavarn, Thomas B. B. Leonard, Shaun Bender, Aliaa Barakat, Janis L. L. Breeze, Peter LaCamera
Summary: In patients with idiopathic pulmonary fibrosis, discontinuing anti-fibrotic therapy < 5 medication half-lives before lung transplant may increase the risk of anastomotic and sternal dehiscence, while there were no differences in other intra-operative and post-transplant complications based on the timing of discontinuation of anti-fibrotic therapy.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
