4.7 Article

One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 46, Pages 7406-7408

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc01996j

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Funding

  1. National Natural Science Foundation of China [31470963, 81371667]

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A new type of membrane fusogenic lipid was prepared to deliver DNA or siRNA into the cytoplasm directly in a fusion-dependent manner in order to bypass the cellular endocytosis to avoid the inefficient escape from the endosome and low transfection efficacy.

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