Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 51, Pages 7935-7938Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc02164f
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Funding
- MEXT (Japan)-Supported Program for the Strategic Research Foundation at Private Universities
- Hirao Taro Foundation of the Konan University Association for Academic Research
- US National Science Foundation [CHE-1406433]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1406433] Funding Source: National Science Foundation
- Grants-in-Aid for Scientific Research [16H02283] Funding Source: KAKEN
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RNA editing from adenosine to inosine (A-to-I editing) is one of the mechanisms that regulate and diversify the transcriptome. Here, a triplex-forming peptide nucleic acid (PNA) modified with a 2-aminopyridine nucleobase was applied for the recognition of the A-to-I editing event in double-stranded RNAs. The triplex-forming PNA enabled sequence-specific detection of single nucleobase editing at sub-nanomolar concentration.
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