4.7 Article

Coupling a DNA-ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 29, Pages 5167-5170

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc10606k

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Funding

  1. National Basic Research Program of China [2012CB720602]
  2. National Natural Science Foundation of China [21210002, 21303182, 21431007, 21533008]

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We have demonstrated the synthesis of a smart nanoprobe by coupling a DNA-ligand ensemble with Ag cluster formation that allows the label-free and ratiometric detection of intracellular biothiols with high sensitivity and selectivity as well as discrimination of normal cells and cancer cells.

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