4.7 Article

Galactose-decorated light-responsive hydrogelator precursors for selectively killing cancer cells

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 85, Pages 12574-12577

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05707a

Keywords

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Funding

  1. NSFC [51573092, 51273111, 51173105]
  2. National Basic Research Program of China (973 Program) [2012CB933803]
  3. Shanghai Jiao Tong University (SJTU) - University of Michigan (UM) Collaborative Research Program
  4. Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning

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A multi-functional gelator precursor with high photosensitivity is rationally designed, which can not only selectively target hepatocellular carcinoma (HCC) cells, but also form intracellular self-assembly triggered by light and subsequently inducing cell death. The study develops amethodology to design biological targets of supramolecular self-assembly under external stimuli for cancer research.

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