Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 18, Pages 3684-3686Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc10317g
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Funding
- Simons Foundation [290363]
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We present a scalable synthesis of 3'-amino-3'-deoxy-2-thio-thymidine-5'-phosphoro-2-methylimidazolide, an activated monomer that can copy adenosine residues in nucleic acid templates rapidly without a polymerase. The sulfur atom substitution enhances the rate of template copying by 5-fold compared with the 3'-amino-3'-deoxy-T monomer, while the 3'-amino monomers exhibit a 2- to 3'-fold enhancement compared with their ribonucleotide counterparts.
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