4.7 Article

Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 9, Pages 1879-1882

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09252c

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Funding

  1. National Natural Science Foundation of China [U1132002, 21571155, 81101243]
  2. National Major Research Special Foundation of China [2013ZX10004805, 2014ZX10004002]
  3. Fundamental Research Funds for the Central Universities

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Conventional therapeuticmonoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs and provides a new intracellular strategy to control viral infections.

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