Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 7, Pages 1482-1485Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc08977h
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Funding
- National Natural Science Foundation of China [21190044, 21221003, 21322509, 21305035, 21305038]
- Hunan Provincial Natural Science Foundation [2015JJ3044]
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An activatable split aptamer probe with target-induced shape change and thermosensitivity was developed. Triggered by proteins on the cell surface, the probe could assemble into a desired binding shape, thus affording a FRET-based tumor cell assay. Moreover, a reversible cell catch/release strategy was realized through mild temperature switching (4 degrees C/37 degrees C).
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