Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Clinical Neurology
Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett
Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Review
Cell Biology
Josh Turknett, Thomas R. Wood
Summary: This article highlights the importance of lifestyle and environment in the development of Alzheimer's Disease. It suggests that previous approaches focusing solely on biological processes have been inadequate, and calls for a holistic approach that incorporates cognitive demand as a primary factor for intervention.
Review
Pharmacology & Pharmacy
Chloe G. McKee, Madison Hoffos, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: As individuals age, microglia, the resident immune cells of the central nervous system (CNS), become less effective at preserving brain circuits. Increases in microglial inflammatory activity are thought to contribute to age-related declines in cognitive functions and to transitions toward mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia are currently underway, but important questions about target selectivity and microglial heterogeneity remain unanswered.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Yasuhisa Ano, Rena Ohya, Akihiko Takashima, Kazuyuki Uchida, Hiroyuki Nakayama
Summary: Research indicates that consuming beta-lactolin can prevent neural inflammation and alleviate aging-related cognitive decline.
FRONTIERS IN NUTRITION
(2021)
Review
Geriatrics & Gerontology
Asma Braham Chaouche, Maryam Rezaei, Daphne Silvestre, Angelo Arleo, Remy Allard
Summary: Age-related decline in visual perception is often attributed to optical and neural factors, with the detection of light by cones being a crucial step in vision. A novel functional approach can evaluate various aspects of the visual system, including the detection of photons by cones, providing insights into the underlying causes of age-related visual decline.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Paul F. Hill, Danielle R. King, Michael D. Rugg
Summary: Study found that regardless of age, the selectivity with which events are neurally processed at the time of encoding can determine the strength of retrieval-related cortical reinstatement.
Review
Nutrition & Dietetics
Sarah Gauci, Lauren M. Young, Lizanne Arnoldy, Annie-Claude Lassemillante, Andrew Scholey, Andrew Pipingas
Summary: This systematic review investigated the relationship between dietary patterns in healthy middle-aged adults and neurocognition both in middle age and later in life. The findings were mixed, with some studies reporting a significant positive relationship between adherence to various healthy dietary patterns and neurocognition, but others reporting no such relationship. However, the review suggests that adherence to the Mediterranean diet and other healthy dietary patterns in middle age can protect neurocognition later in life.
Article
Neurosciences
Bjorn Herrmann, Burkhard Maess, Molly J. Henry, Jonas Obleser, Ingrid S. Johnsrude
Summary: Listening in everyday life requires the dynamic deployment of attention in order to conserve mental resources, especially for older adults. This study used electroencephalography and magnetoencephalography to investigate the neural and behavioral mechanics of attention regulation during listening and how aging affects these processes. The results showed that younger and older adults employ different neural control strategies to regulate attention in time under listening challenges, with a notable difference in the sources of alpha activity between age groups.
Article
Geriatrics & Gerontology
Monique J. Brown, Nikki L. Hill, Mohammad Rifat Haider
Summary: Depression was found to be positively associated with SCD and various related outcomes by age and gender, suggesting the importance of considering depression in SCD interventions, tailored to different age groups and genders.
AGING & MENTAL HEALTH
(2022)
Article
Nutrition & Dietetics
Aleksandra Bramorska, Wanda Zarzycka, Wiktoria Podolecka, Katarzyna Kuc, Aneta Brzezicka
Summary: The study found that the frequency of food consumption moderates the relationship between age and cognitive functioning, with dietary patterns having a stronger impact on cognitive performance in older adults.
Article
Neurosciences
Fabrizio Sanna, Francesco Loy, Raffaella Piras, Alan Moat, Carla Masala
Summary: The study found that olfactory, gustatory, and cognitive functions decline with age, but depression level does not significantly differ across age ranges. Depression level is associated with sex, odor identification impairment, and decreased attention and language skills.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Educational
Andrew Lynn, John Maule, Dima Amso
Summary: This study found that the development of visual processing and attention in children is closely related to visual features such as color and luminance. Furthermore, changes in feature search and incidental feature integration for luminance and color-defined targets were positively correlated with age. The results also suggest that individual differences in feature search and incidental feature integration mediate age-related changes in visual selective attention.
Article
Biochemistry & Molecular Biology
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota Tatara, Junsei Mimura, Mate Janos Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
Summary: Sulforaphane (SFN) has shown to improve age-related cognitive decline. This study found that broccoli sprout powder containing sulforaphane glucosinolate (SGS) can prevent cognitive decline in senescence-accelerated mice by maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Donatella Coradduzza, Stefania Sedda, Sara Cruciani, Maria Rosaria De Miglio, Carlo Ventura, Alessandra Nivoli, Margherita Maioli
Summary: This systematic review and meta-analysis investigated the relationship between the gut microbiome and cognitive function in the context of aging. The findings suggest that altered microbial abundance, particularly in specific phyla, is associated with cognitive impairments in diseases such as Alzheimer's disease, Parkinson's disease, and dementia. However, there is substantial heterogeneity among studies, highlighting the complexity of the relationship between the gut microbiome and cognitive function. Further research is needed to understand the mechanisms and potential implications of this connection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Swagata Ghatak, Nima Dolatabadi, Richard Gao, Yin Wu, Henry Scott, Dorit Trudler, Abdullah Sultan, Rajesh Ambasudhan, Tomohiro Nakamura, Eliezer Masliah, Maria Talantova, Bradley Voytek, Stuart A. Lipton
Summary: Early stages of human Alzheimer's disease (AD) show hyperexcitability in the brain, leading to extensive synapse loss and cognitive dysfunction, with no current disease-modifying therapy available. Utilizing human iPSC models may be a valuable tool for screening drugs to treat hyperexcitability and synaptic damage in AD, potentially increasing the chances of success in treatment.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Ileana L. Hanganu-Opatz, Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco Garcia, Jessica A. Cardin, Bradley Voytek, Alysson R. Muotri
Summary: This review summarizes recent research on the development of the mammalian neocortex, from genetic determination in neural stem cells to the dynamic role of specific neuronal populations in the earliest circuits of the neocortex, and how they contribute to emergent function and cognition. The perspective across species is imperative when investigating the dysfunction of early neocortical circuits in neurodevelopmental disorders, in order to identify targets for therapeutic intervention.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Thomas Donoghue, Natalie Schaworonkow, Bradley Voytek
Summary: Neural oscillations are prevalent and associated with cognitive tasks, offering an exciting opportunity to link theory, physiology, and mechanisms of cognition. However, careful consideration of the underlying assumptions of the methods used is necessary for proper interpretation of investigations into neural oscillations. Seven methodological considerations for analyzing neural oscillations are discussed, providing a helpful guide for measurement and interpretation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Daril E. Brown, Jairo Chavez, Derek H. Nguyen, Adam Kadwory, Bradley Voytek, Ezequiel M. Arneodo, Timothy Q. Gentner, Vikash Gilja
Summary: The research shows that neuronal activity within the HVC of birds is tightly synchronized with vocal behavior, and local field potentials (LFP) can be used to analyze and study avian singing behavior.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Natalie Schaworonkow, Bradley Voytek
Summary: Invasive electrophysiological recordings of human brain activity can capture a variety of neural oscillations with overlap in space and time. By using spatial filters, researchers can explore variability in oscillation presence across subjects, as well as spatial spread and waveform shapes of different rhythms. Improved measurement of cortical rhythms through data-driven referencing schemes can enhance understanding of brain activity and behavior.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Thomas Donoghue, Bradley Voytek
Summary: Event-related potentials (ERPs) are a common method for studying the neural basis of cognition and disease. An automated text-mining approach was used for meta-analysis to examine relationships between ERP terms, cognitive domains, and clinical disorders. The project aims to create data-driven profiles for each ERP, analyze key associations of each component, compare similarities across components, and ultimately characterize patterns and associations between topics and components.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Leonhard Waschke, Thomas Donoghue, Lorenz Fiedler, Sydney Smith, Douglas D. Garrett, Bradley Voytek, Jonas Obleser
Summary: The study found that the spectral exponent of non-invasive EEG recording is sensitive to changes in E:I balance and can also track stimulus spectral exponents in auditory and visual sensory cortices. The degree of selective stimulus-brain coupling in spectral exponents predicted behavioral performance.
Article
Psychology, Developmental
Brendan Ostlund, Thomas Donoghue, Berenice Anaya, Kelley E. Gunther, Sarah L. Karalunas, Bradley Voytek, Koraly E. Perez-Edgar
Summary: This paper discusses the importance of the explicit parameterization of neural power spectra in cognitive neuroscience research, and introduces an automated spectral parameterization algorithm. The paper provides annotated code for power spectral parameterization and demonstrates its utility through an analysis of EEG data in children. Ultimately, the explicit parameterization of EEG power spectra helps refine our understanding of the impact of dynamic neural communication on cognition across the lifespan.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Editorial Material
Biochemical Research Methods
Bradley Voytek
Summary: This approach enables neuroscientists to integrate heterogeneous brain data and place it within a broader neuroscientific context.
Article
Neurosciences
Manuel R. Mercier, Anne-Sophie Dubarry, Francois Tadel, Pietro Avanzini, Nikolai Axmacher, Dillan Cellier, Maria Del Vecchio, Liberty S. Hamilton, Dora Hermes, Michael J. Kahana, Robert T. Knight, Anais Llorens, Pierre Megevand, Lucia Melloni, Kai J. Miller, Vitoria Piai, Aina Puce, Nick F. Ramsey, Caspar M. Schwiedrzik, Sydney E. Smith, Arjen Stolk, Nicole C. Swann, Mariska J. Vansteensel, Bradley Voytek, Liang Wang, Jean-Philippe Lachaux, Robert Oostenveld
Summary: Intracranial electroencephalography (iEEG) provides a detailed understanding of the human brain. This article critically reviews iEEG research practices, provides guidelines for newcomers, and addresses issues faced by experienced researchers. The paper covers data collection, electrode localization, preprocessing steps, signal analysis methods, statistical approaches, and unique perspectives on iEEG research. A glossary is also provided for consistent terminology.
Review
Psychiatry
Jumana Ahmad, Claire Ellis, Robert Leech, Bradley Voytek, Pilar Garces, Emily Jones, Jan Buitelaar, Eva Loth, Francisco Pascoa dos Santos, Adrian F. Amil, Paul F. M. J. Verschure, Declan Murphy, Grainne McAlonan
Summary: Brain function is influenced by the balance between excitatory and inhibitory activity, and disruptions in this balance are thought to contribute to a range of neuropsychiatric conditions. However, there is a lack of validated methods for assessing excitatory and inhibitory function in humans. Recent research has identified novel EEG markers that could serve as proxy indicators of excitatory and inhibitory activity at specific neural levels.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Erik J. Peterson, Burke Q. Rosen, Aysenil Belger, Bradley Voytek, Alana M. Campbell
Summary: This paper investigated the differences in oscillatory and aperiodic activity between patients with schizophrenia and healthy controls during a target detection task. The steepness of the power spectrum better predicted group status than traditional band-limited oscillatory power. Aperiodic activity outperformed predictions made using participants' behavioral responses. The differences in aperiodic activity were highly consistent across all electrodes, suggesting it as a more accurate and robust way to differentiate patients with schizophrenia from healthy controls.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Psychiatry
Sydney E. Smith, Vincent Ma, Celene Gonzalez, Angela Chapman, David Printz, Bradley Voytek, Maryam Soltani
Summary: This exploratory study on nine MDD patients shows that aperiodic activity increases with ECT treatment and better explains EEG slowing compared to power in oscillatory peaks. This increase in aperiodic activity is linked to increasing levels of inhibitory activity, suggesting that ECT may ameliorate depressive symptoms by restoring healthy levels of inhibition in frontal cortices.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Juan Molina, Joyce Sprock, Dylan Iwanaga, Jo Talledo, Yash Joshi, Bradley Voytek, Lisa Delano-Wood, Christopher Gonzalez, Steven Huege, Gabriel Leger, Greg Light, Neal Swerdlow
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Education, Scientific Disciplines
Thomas Donoghue, Bradley Voytek, Shannon E. Ellis
Summary: The article discusses the shift in statistical education to include computing and the response of universities to the growing demand for data science education. The course focuses on project-based learning, practical application, standardized tools, and ethical considerations, aiming to prepare students for interdisciplinary work and emphasize creative problem solving.
JOURNAL OF STATISTICS AND DATA SCIENCE EDUCATION
(2021)