Severe Acute Lung Injury Related to COVID‐19 Infection: A Review and the Possible Role for Escin

Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis

(2020) Holger Müller-Redetzky et al.   ANESTHESIOLOGY

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

Coronavirus infections and immune responses

(2020) Geng Li et al.   JOURNAL OF MEDICAL VIROLOGY

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

(2020) Clark D Russell et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial

(2020) Yaseen M. Arabi et al.   Trials

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection

(2020) David N. Juurlink   CANADIAN MEDICAL ASSOCIATION JOURNAL

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

(2020) Lisi Deng et al.   JOURNAL OF INFECTION

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

(2020) Li Runfeng et al.   PHARMACOLOGICAL RESEARCH

Escin suppresses HMGB1-induced over-expression of aquaporin-1 and increased permeability in endothelial cells

(2019) Changjun Chen et al.   FEBS Open Bio

Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo

(2019) Franco Maximiliano Salinas et al.   ANTIVIRAL RESEARCH

Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome

(2019) Chelsea Kotch et al.   Expert Review of Clinical Immunology

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties

(2019) Luca Gallelli   Drug Design Development and Therapy

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza

(2019) Louise E. Lansbury et al.   CRITICAL CARE MEDICINE

Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

(2018) Yaseen M. Arabi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of adjuvant immunomodulatory agents for treatment of severe influenza

(2018) David S. Hui et al.   ANTIVIRAL RESEARCH

FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell‐Induced Severe or Life‐Threatening Cytokine Release Syndrome

(2018) Robert Q. Le et al.   ONCOLOGIST

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

(2018) Yaseen M. Arabi et al.   Trials

Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract

(2018) Flavia M. Michelini et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications

(2016) Dominik Domanski et al.   PLoS One

Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury

(2014) Dai-Kun He et al.   INHALATION TOXICOLOGY

The impact of sodium aescinate on acute lung injury induced by oleic acid in rats

(2011) Tian Wei et al.   EXPERIMENTAL LUNG RESEARCH

Escin attenuates acute lung injury induced by endotoxin in mice

(2010) Wenyu Xin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro

(2010) Wenyu Xin et al.   PHYTOMEDICINE

Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases

(2008) Ewa Jablonska et al.   THROMBOSIS AND HAEMOSTASIS