Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Monica Macellaro, Nicolaja Girone, Laura Cremaschi, Monica Bosi, Bruno Mario Cesana, Federico Ambrogi, Valentina Caricasole, Federica Giorgetti, Terence A. Ketter, Bernardo Dell'Osso
Summary: This study retrospectively evaluated the applicability and progression of four staging models in a sample of 100 bipolar disorder patients. The results showed a pattern of stage worsening for each model, with a significant increase at each time point. Patients with lower education level, younger age at first episode, shorter illness duration, and shorter duration of untreated illness showed greater stage increases. Lower stage values were associated with certain characteristics, such as BD II, no psychiatric hospitalization, depressive onset, and few lifetime episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Praharaj, Vikas Menon, Raman Deep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, AbMajid Gania, Bhavesh Lakdawala, Ranjan Bhattacharya
Summary: This multicentric study from India examined the long term course and outcome of bipolar disorder (BD), finding that the average number of manic episodes in the study sample exceeded the average number of depressive episodes. A higher proportion of males had a history of co-morbid substance dependence.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Tim B. Bigdeli, Ayman H. Fanous, Yuli Li, Nallakkandi Rajeevan, Frederick Sayward, Giulio Genovese, Rishab Gupta, Krishnan Radhakrishnan, Anil K. Malhotra, Ning Sun, Qiongshi Lu, Yiming Hu, Boyang Li, Quan Chen, Shrikant Mane, Perry Miller, Kei-Hoi Cheung, Raquel E. Gur, Tiffany A. Greenwood, David L. Braff, Eric D. Achtyes, Peter F. Buckley, Michael A. Escamilla, Douglas Lehrer, Dolores P. Malaspina, Steven A. McCarroll, Mark H. Rapaport, Marquis P. Vawter, Michele T. Pato, Carlos N. Pato, Hongyu Zhao, Thomas R. Kosten, Mary Brophy, Saiju Pyarajan, Yunling Shi, Timothy J. O'Leary, Theresa Gleason, Ronald Przygodzki, Sumitra Muralidhar, J. Michael Gaziano, Grant D. Huang, John Concato, Larry J. Siever, Mihaela Aslan, Philip D. Harvey
Summary: Schizophrenia and bipolar disorder are debilitating neuropsychiatric disorders that collectively affect 2% of the world's population. A recent study on US Veterans revealed new susceptibility loci and associations for these disorders, demonstrating the robust generalizability of published findings and providing insights for future research.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Clinical Neurology
Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Kumar Praharaj, Vikas Menon, Ramandeep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, Prasonjit Ghosh, Bhavesh Lakdawala, Ranjan Bhattacharya
Summary: The presence of psychotic symptoms in patients with bipolar disorder is associated with a more severe course of the illness, including lower age of onset, higher episode rates, and higher rates of suicide attempts and hospitalizations. However, the presence of psychotic symptoms is also associated with better cognitive functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jian Zhou, Xiaowei Jiang, Yifang Zhou, Yue Zhu, Linna Jia, Ting Sun, Linzi Liu, Qikun Sun, Luyu Ren, Yanan Guo, Feng Wu, Lingtao Kong, Yanqing Tang
Summary: This study compared white matter network alterations between patients with remitted major depressive disorder (rMDD) and remitted bipolar disorder (rBD). The findings showed specific changes in certain brain regions that could potentially distinguish between these two affective disorders during remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Developmental
Han-Sian Yang, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Teenage pregnancy is a significant public health issue, and there is an association between bipolar disorder and early pregnancy. However, bipolar disorder medications may reduce the risk of early pregnancy.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Oncology
Shih-Hao Ou, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu, Hsuan-Chih Lin
Summary: The study indicates that the presence of sleep disorders in patients with oral squamous cell carcinoma can affect oncologic outcomes, and screening for sleep problems before treatment may serve as a predictor of survival for these patients.
Article
Clinical Neurology
Charles Laidi, Ophelia Godin, Bruno Etain, Frank Bellivier, Yannis Elandaloussi, Emilie Olie, Bruno Aouizerate, Sebastien Gard, Josephine Loftus, Raoul Belzeaux, Caroline Dubertret, Hakim Laouamri, Christine Passerieux, Agnes Pelletier, Mircea Polosan, Raymund Schwan, Ludovic Samalin, Pierre-Michel Llorca, Philippe Courtet, Isabelle Durand-Zaleski, Marion Leboyer
Summary: This study aims to estimate the direct healthcare cost associated with bipolar disorder and to study the evolution of cost during a two-year follow-up period. Previous studies have mainly relied on insurance claims data and have limited information on the clinical characteristics and course of bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Faith Dickerson, Andrea Origoni, Kelly Rowe, Emily Katsafanas, Theresa Newman, Rita S. Ziemann, Amalia Squire, Sunil Khushalani, Cassie Stallings, Gail Daumit, Robert Yolken
Summary: Research shows that individuals with serious mental illness have a higher natural cause mortality rate, with factors such as smoking, diseases like diabetes and hypertension, lower cognitive functioning, divorced/separated status, and the use of specific medications contributing to the risk.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Mette Bagge Jensen, Hanne Lie Kjaerstad, Klara Coello, Sharleny Stanislaus, Sigurd Melbye, Kimie Ormstrup Sletved, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: The study found no significant differences in cognitive profiles between recently diagnosed BD-I and BD-II, indicating that neither affective nor non-affective cognition are indicative of BD subtype.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
B. Etain, F. Bellivier, E. Olie, B. Aouizerate, V. Aubin, R. Belzeaux, P. Courtet, C. Dubertret, R. Schwan, P. Roux, M. Polosan, M. Leboyer, O. Godin
Summary: The study found that the time to first recurrence of any polarity was earlier in BD-II compared to BD-I, with first depressive recurrence occurring earlier in BD-II and first (hypo)manic recurrence occurring earlier in BD-I. In clinical terms, predictors of the time to a first mood recurrence in BD-I were associated with depressive symptoms, lifetime rapid cycling, global activation, and the number of psychotropic medications at baseline, while in BD-II, predictors were associated with a younger age at onset of BD and a higher number of lifetime mood episodes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Ingrid Lieber, Michael Ott, Robert Lundqvist, Mats Eliasson, Mikael Sandlund, Ursula Werneke
Summary: This study investigated the relevance of hyperthyroxinaemia as a risk factor for lithium intoxication and found that hyperthyroxinaemia was associated with a low incidence of unintentional lithium intoxication. There was no direct causal link between hyperthyroxinaemia and altered tubular renal function. Therefore, increasing the frequency of thyroid function tests may not reduce the risk of lithium intoxication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Liliana Gomez Cardona, Kristyn Brown, Taylor Goodleaf, Mary McComber, Rebecca D'Amico, Allyson Phillips, Cyndy Boyer, Codey Martin, Brooke Splicer, Suzy Goodleaf, Darrell Thompson, Melissa Haswell, Arlene Laliberte, Outi Linnaranta
Summary: The study culturally adapted the Growth and Empowerment Measure for the Kanien'keha:ka people of Quebec, using a qualitative, collaborative, and participatory approach. Through focus group meetings and data analysis, socioculturally relevant elements were integrated to create a versatile assessment tool reflecting local well-being factors.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
Petri Arvilommi, Jukka Valkonen, Lars H. LIndholm, Selma Gaily-Luoma, Kirsi Suominen, Outi M. Ruishalme, Marena Kukkonen, Harri Sihvola, Erkki Isometsa
Summary: This study compared the effectiveness of the Attempted Suicide Short Intervention Program (ASSIP) and crisis counseling (CC) in preventing repeat suicide attempts, and found no significant difference between the two interventions.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2022)
Article
Psychiatry
Johan Ahti, Tuula Kieseppa, Jaana Suvisaari, Kimmo Suokas, Minna Holm, Asko Wegelius, Ari Ahola-Olli, Katja Hakkinen, Olli Kampman, Markku Lahteenvuo, Tiina Paunio, Jari Tiihonen, Annamari Tuulio-Henriksson, Erkki Isometsa
Summary: This study compared psychosocial functioning between schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder with psychotic features. The results showed that schizophrenia had the worst level of functioning, while bipolar disorder had the best. Gender and number of hospitalizations were strongly associated with marriage, employment, and independent living across all diagnostic categories.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Clinical Neurology
Gerard Anmella, Maria Faurholt-Jepsen, Diego Hidalgo-Mazzei, Joaquim Radua, Ives C. Passos, Flavio Kapczinski, Luciano Minuzzi, Martin Alda, Sandra Meier, Tomas Hajek, Pedro Ballester, Boris Birmaher, Danella Hafeman, Tina Goldstein, Elisa Brietzke, Anne Duffy, Benno Haarman, Carlos Lopez-Jaramillo, Lakshmi N. Yatham, Raymond W. Lam, Erkki Isometsa, Rodrigo Mansur, Roger S. McIntyre, Benson Mwangi, Eduard Vieta, Lars Vedel Kessing
Summary: This study examined the effectiveness of smartphone-based interventions for bipolar disorder (BD) and how the included studies reported user-engagement indicators. The results showed no evidence to support the reduction of depressive or manic symptoms in BD through smartphone interventions. The high heterogeneity among studies suggests the need for expert consensus and the use of more sensitive outcomes in future research.
Article
Psychiatry
Petri Arvilommi, Sanna Pallaskorpi, Outi Linnaranta, Kirsi Suominen, Sami Leppamaki, Hanna Valtonen, Erkki Isometsa
Summary: This study investigated the predictors of long-term work disability among patients with bipolar disorder (BD). The results showed that older age, type I BD, comorbidities with generalized anxiety disorder, post-traumatic stress disorder, or avoidant personality disorder, and duration of depressive or mixed symptoms were associated with disability pensions.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2022)
Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kursat Altinbas, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Ana Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsa, Maja Ivkovic, Sven Janno, Simon Johnsen, Flavio Kapczinski, Gregory N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara Koenig, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landen, Erik R. Larsen, Melanie Lenger, Ute Lewitzka, Rasmus W. Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Ostergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Ybe Meesters, Ingrid Melle, Fatima Meza-Urzua, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, Rene Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Michaela Ratzenhofer, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, Jose Smith, Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow
Summary: This study investigated the relationship between solar insolation and the polarity of the first episode of BD I. The results showed that the greater the change in solar insolation throughout the year, the more likely the first episode polarity was depression. Other associated variables included being female and increasing percentage of gross domestic product spent on country health expenditures. This study highlights the need for increased awareness and research into circadian dysfunction throughout the course of BD.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Clinical Neurology
Tuukka T. Raij, Emma Komulainen, Dogu Baran Aydogan, Siina Pamilo, Erkki Isometsa, Tommi Raij
Summary: This study successfully improved the efficacy of transcranial magnetic stimulation (TMS) treatment for depression by constructing a core network model (CNM) and found that DLPFC connectivity is closely associated with the severity of depression and TMS efficacy.
Article
Clinical Neurology
Ilya Baryshnikov, Talayeh Aledavood, Tom Rosenstrom, Roope Heikkila, Richard Darst, Kirsi Riihimaki, Outi Saleva, Jesper Ekelund, Erkki Isometsa
Summary: This study aimed to investigate whether depressed patients accurately recall their recent mood states when completing the Patient Health Questionnaire (PHQ-9). The results showed that despite fluctuations in the severity of depressive symptoms, patients with depression were able to accurately recall their most dominant symptoms without a recall bias favoring the most recent days.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, Research & Experimental
Katja Hakkinen, Wilma Kiander, Heidi Kidron, Markku Lahteenvuo, Lea Urpa, Jonne Lintunen, Kati-Sisko Vellonen, Seppo Auriola, Minna Holm, Kaisla Lahdensuo, Olli Kampman, Erkki Isometsa, Tuula Kieseppa, Jouko Lonnqvist, Jaana Suvisaari, Jarmo Hietala, Jari Tiihonen, Aarno Palotie, Ari V. Ahola-Olli, Mikko Niemi
Summary: Six rare SLCO1B1 single nucleotide variants (SNVs) were identified in Finnish individuals with a psychotic disorder, which may affect the expression and functionality of the OATP1B1 protein. Functional studies showed that one of these SNVs (c.629G>T) resulted in the loss of OATP1B1 function and decreased membrane protein expression.
MOLECULAR PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Markku Lahteenvuo, Ari Ahola-Olli, Kimmo Suokas, Minna Holm, Zuzanna Misiewicz, Tuomas Jukuri, Teemu Maennynsalo, Asko Wegelius, Willehard Haaki, Risto Kajanne, Aija Kyttala, Annamari Tuulio-Henriksson, Kaisla Lahdensuo, Katja Hakkinen, Jarmo Hietala, Tiina Paunio, Jussi Niemi-Pynttari, Tuula Kieseppa, Juha Veijola, Jouko Lonnqvist, Erkki Isometsa, Olli Kampman, Jari Tiihonen, Steven Hyman, Benjamin Neale, Mark Daly, Jaana Suvisaari, Aarno Palotie
Summary: The purpose of this study is to establish a large Finnish collection of psychosis cases, including diverse populations from Asia, Latin America, and Africa, in addition to known population isolates like Finland. A total of 10,474 individuals aged 18 years or older were recruited and genotyped. The future plans of this study include investigating the effects of common variants, rare variants, and copy number variations on the severity of psychotic illness, as well as tracking the longitudinal course of illness based on nationwide register data.
Article
Psychiatry
Kirsi Riihimaki, Harri Sintonen, Maria Vuorilehto, Erkki Isometsa
Summary: Depression affects health-related quality of life, and it is not known at what degree of remission depressive patients' HRQoL corresponds to the normal range.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kuersat Altinbas, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Michael J. Gitlin, Ana. Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsa, Maja Ivkovic, Sven Janno, Simon Johnsen, Flavio Kapczinski, Gregory N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara Koenig, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landen, Erik R. Larsen, Melanie Lenger, Rasmus W. Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Ostergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Ybe Meesters, Ingrid Melle, Fatima Meza-Urzua, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin V. Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, Rene Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard J. Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Michaela Ratzenhofer, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, Jose Smith, Jr Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow
Summary: This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production. The results showed that the age of onset at locations with UVB threshold below the threshold was 1.66 years younger than those with UVB threshold equal to or above the threshold. The conclusion suggests that UVB and vitamin D may play an important role in the development of bipolar disorder.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Health Care Sciences & Services
Quinta Seon, Noor Mady, Michelle Yang, Maharshee Karia, Myrna Lashley, Claudia Sescu, Maud Lalonde, Stephen Puskas, Joy Outerbridge, Echo Parent-Racine, Catherine Pagiatakis, Liliana Gomez-Cardona, Di Jiang, Stephane Bouchard, Outi Linnaranta
Summary: This study presents a protocol for a culturally adapted virtual reality cognitive behavioral therapy trial among Inuit in Quebec. The research aims to investigate the feasibility, benefits, and challenges of the culturally adapted intervention compared to a commercial self-management program, as well as examine self-rated mental well-being and objective psychophysiological measures. The study's importance lies in meeting the need for accessible and appropriate psychological well-being resources for Inuit, incorporating novel technology and measurement methods, and providing evidence for culturally adapted RCTs.
JMIR RESEARCH PROTOCOLS
(2023)
Review
Psychiatry
Michelle Yang, Quinta Seon, Liliana Gomez Cardona, Maharshee Karia, Gajanan Velupillai, Valerie Noel, Outi Linnaranta
Summary: Implementing culturally sensitive psychometric measures of depression can improve acceptance and reliability. However, the psychometric properties of culturally adapted depression scales remain unclear, with some improvements in cultural sensitivity but potential decreases in specificity and negative predictive value.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)