4.7 Article

A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 9, Pages 1843-1846

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc08636a

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Funding

  1. Defense Threat Reduction Agency [HDTRA1-13-1-0046]
  2. Deutsche Forschungsgemeinschaft [SFB 1032]

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A novel thermoresponsive snaptop for stimulated cargo release from superparamagnetic iron oxide core - mesoporous silica shell nanoparticles based on a [2 + 4] cycloreversion reaction (retro-Diels Alder reaction) is presented. The non-invasive external actuation through alternating magnetic fields makes this material a promising candidate for future applications in externally triggered drug delivery.

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