Review
Oncology
Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, E. A. R. Engku Nur Syafirah, Yusuf Wada, Zaidah Abdul Rahman, Suhana Ahmad, Rohimah Mohamud, Norhafiza Mat Lazim, Chan Yean Yean
Summary: This study found that the prevalence of nasopharyngeal carcinoma in dermatomyositis patients is 3.3%, with higher rates in certain regions like Hong Kong, Malaysia, and Singapore. There is a higher incidence among male patients aged 40 and above, with many cases of NPC being diagnosed after the onset of dermatomyositis. Screening for NPC in older dermatomyositis patients, especially in the Asian region, is therefore essential.
Review
Otorhinolaryngology
Qiuji Wu, Shaojie Li, Jia Liu, Yahua Zhong
Summary: For locally advanced nasopharyngeal carcinoma, induction chemotherapy plus sequential chemoradiotherapy significantly improves progression-free survival and overall survival compared to radiotherapy alone. Among different induction chemotherapy regimens, gemcitabine and cisplatin show the best efficacy and higher treatment compliance.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Oncology
Horace Cheuk-Wai Choi, Sik-Kwan Chan, Ka-On Lam, Sum-Yin Chan, Sze-Chun Chau, Dora Lai-Wan Kwong, To-Wai Leung, Mai-Yee Luk, Anne Wing-Mui Lee, Victor Ho-Fun Lee
Summary: This study aimed to compare the survival benefits of all available induction chemotherapy (IC) regimens followed by concurrent chemoradiotherapy (CCRT) in non-metastatic locoregionally advanced nasopharyngeal carcinoma (NPC) through a network meta-analysis. The results showed that DC, GP, and PX were the most efficacious IC regimens, with doublet and gemcitabine-based regimens demonstrating better survival benefits compared to triplet and taxane-based regimens.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mengshan Ni, Lijun Geng, Fangfang Kong, Chengrun Du, Ruiping Zhai, Yingchen Lyu, Chaosu Hu, Hongmei Ying
Summary: The study analyzed the therapeutic effect and prognostic factors of NPC patients with distant metastases at initial diagnosis receiving induction chemotherapy with IMRT. The results showed that platinum-containing induction chemotherapy combined with IMRT could prolong survival for some patients, but factors like pre-treatment SLDH, number of chemotherapy cycles, and M1 subcategories were associated with poor overall survival. Prospective clinical trials are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Tsung-You Tsai, Yung-Chih Chou, Yi-An Lu, Chung-Jan Kang, Shiang-Fu Huang, Chun-Ta Liao, Kai-Ping Chang
Summary: The study revealed that radiologic extranodal extension (rENE) is a significant prognostic factor in nasopharyngeal carcinoma. Both ungraded and unambiguous advanced rENE were associated with worse overall survival and distant metastasis-free survival, highlighting their importance in prognostic evaluation.
Review
Otorhinolaryngology
Ting Liu, Shuang Dai, Hao Zhang, Xi Zhong, Zhenyu Ding, Xuelei Ma
Summary: This study demonstrates that the combined IC regimen of gemcitabine plus cisplatin (GP) is the most beneficial for patients with locally advanced nasopharyngeal carcinoma, providing both overall survival benefit and longer distant metastasis-free survival. The GP regimen appears to be the optimal choice for these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Alberto Bongiovanni, Alessandro Vagheggini, Valentina Fausti, Laura Mercatali, Sebastiano Calpona, Giandomenico Di Menna, Giacomo Miserocchi, Toni Ibrahim
Summary: For locally-advanced nasopharyngeal carcinoma (NPC), adding specific chemotherapy drugs to concurrent chemoradiotherapy has shown to improve overall survival and locoregional recurrence-free survival in patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Shan-Shan Yang, Jian-Gui Guo, Jia-Ni Liu, Zhi-Qiao Liu, En-Ni Chen, Chun-Yan Chen, Pu-Yun OuYang, Fei Han, Fang-Yun Xie
Summary: The meta-analysis showed that induction chemotherapy in patients with nasopharyngeal carcinoma significantly prolonged progression free survival and overall survival, while improving locoregional and distant control rates. The incidence of grade 3-4 adverse events during concurrent chemoradiotherapy was higher in the induction chemotherapy group, including leukopenia, thrombocytopenia, and fatigue.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Guoxiang Wang, Liangfang Shen
Summary: The meta-analysis demonstrated that for patients with M-NPC, chemotherapy combined with locoregional radiotherapy (LRT) is superior to chemotherapy alone in terms of overall survival, progression-free survival, objective response rate, and disease control rate. Therefore, it is recommended that M-NPC patients opt for chemotherapy combined with LRT as a more suitable treatment choice.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinzhi Teng, Jiang Zhang, Xinyang Han, Jiachen Sun, Sai-Kit Lam, Qi-Yong Hemis Ai, Zongrui Ma, Francis Kar-Ho Lee, Kwok-Hung Au, Celia Wai-Yi Yip, James Chung Hang Chow, Victor Ho-Fun Lee, Jing Cai
Summary: The purpose of this study was to discover intra-tumor heterogeneity signature and validate its predictive value for adjuvant chemotherapy (ACT) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. The results show that predictive radiomic features and subvolumes can effectively predict treatment outcomes, providing a decision-making tool for clinical practice.
Review
Oncology
Fangrui Zhao, Dashuai Yang, Xiangpan Li
Summary: Nasopharyngeal carcinoma is a malignant tumor mainly found in East and Southeast Asia. Radical radiotherapy is the primary treatment for this type of cancer. However, interruptions in radiotherapy can lead to reduced effectiveness and potential tumor progression. This review examines the effects of radiotherapy interruption and explores possible measures to address this issue.
FRONTIERS IN ONCOLOGY
(2023)
Review
Multidisciplinary Sciences
Min Kyoung Lee, Yangsean Choi, So-Lyung Jung
Summary: This meta-analysis showed that pretreatment ADC in nasopharyngeal carcinoma patients has good predictive performance for treatment response, with high sensitivity and moderate specificity.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Haiyan Feng, Ying Zhou, Liuzhen Wang, Yiling Wang, Shiping Zhou, Fanyun Tian
Summary: This systematic review and meta-analysis found a significant association between consumption of processed foods and risk of nasopharyngeal carcinoma (NPC), with the highest intake being associated with a 65% increased risk compared to the lowest intake. Significant positive associations were observed in both Asians and Caucasians.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Dan Li, Hai-Ke Lei, Xiao-Lei Shu, Xin Zhang, Hong-Lei Tu, Feng Wang, Yu-Wei Wang, Ying Wang, Jiang-Dong Sui
Summary: Health insurance programs are effective in preventing financial hardship in cancer patients. However, little is known about how health insurance policies influence the prognosis of patients with nasopharyngeal carcinoma in Southwest China. This study investigated the association of insurance types and self-paying rates with NPC-specific mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Oncology
Bi-Cheng Wang, Bo-Hua Kuang, Xin-Xiu Liu, Guo-He Lin, Quentin Liu
Summary: Different induction chemotherapeutic strategies have varying effects and risks on the survival outcomes of patients with locoregionally advanced nasopharyngeal carcinoma. Gemcitabine plus platinum and docetaxel combined with 5-fluorouracil plus platinum strategies were associated with the highest rates of overall survival. The objective response and disease control rates were high after the completion of induction chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
