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Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Jie Wang, Zhiwei He, Jian Xu, Peng Chen, Jianxin Jiang
Summary: The study found that LINC00941 acts as an oncogene in the progression of pancreatic cancer, functioning as a ceRNA for miR-335-5p. High expression of LINC00941 was associated with tumor size, lymph node metastasis, and poor prognosis, and its silencing significantly inhibited cell growth and metastasis in PC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Oncology
Shili Ning, Yuzhuo Chen, Guangzhi Wang, Yongtai Liu, Yingchi Yang, Zhongtao Zhang
Summary: The study found that high expression of RNF128 in colorectal cancer tissues is associated with enhanced proliferation, migration, and invasion abilities of cancer cells, and it promotes malignant behaviors by inhibiting the Hippo signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Huiling Liao, Lan Zhang, Shimin Lu, Wei Li, Weiguo Dong
Summary: This study found that KIFC3 is highly expressed in colorectal cancer (CRC) and is negatively correlated with patient survival. Silencing of KIFC3 inhibits proliferation, migration, and invasion of CRC cells, and regulates the cell cycle and epithelial-to-mesenchymal transition (EMT) process. Furthermore, KIFC3 modulates the EMT process through the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Sang-Soo Park, Yea Seong Ryu, Dong-In Koh, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Mi Jin Kim, Do Yeon Kim, Jun Ki Hong, Eun Ho Kim, Hong-Rae Jeong, Yoon Sun Park, Joseph Kim, Dong Min Kim, Hyeseon Yun, Joo-Yeon Shin, Dong-Hoon Jin
Summary: SVCT2 E264K mutation plays a critical role in proliferation in colorectal cancer (CRC), with its overexpression increasing cell growth and knockdown reducing cell proliferation while promoting apoptosis. The findings suggest that SVCT2 E264K could be a promising novel therapeutic target in CRC.
Article
Biotechnology & Applied Microbiology
Qi-Qi Zhan, Qian-Yu Liu, Xin Yang, Yu-Hui Ge, Lei Xu, Guan-Yi Ding, Shang Guo, Bing Zhu, Wei-Guo Xu
Summary: The silencing of neuropilin-2 (NRP-2) was found to significantly inhibit the proliferation, migration, and invasion abilities of colorectal cancer HT-29 cells.
Article
Biochemistry & Molecular Biology
Le Du, Ning Liu, Jianfeng Jin, Meng Cao, Yuantian Sun, Xinzheng Gao, Banzhan Ruan, Shangfeng Yang, Dongsheng Ge, Yingzhuan Ye, Yinxi Zhou, Erfei Chen, Jin Yang
Summary: Colorectal cancer is a highly prevalent and deadly tumor. This study investigated the role of zinc finger protein 3 (ZNF3) in colorectal cancer and found that ZNF3 is highly expressed in colorectal cancer tissue and cells, particularly in older patients. Overexpression of ZNF3 promotes cell migration, while knockdown of ZNF3 suppresses cell proliferation, migration, and invasion and induces cell cycle arrest. ZNF3 appears to regulate the expression of TWIST and MMP1, which are involved in epithelial-mesenchymal transition, and their overexpression exacerbates cell proliferation and affects cell functions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Cell Biology
Yang Bai, Ling Li, Zhiyong Zhang
Summary: This study found that Linc00883 plays a promoting role in the proliferation, invasion, and migration of colorectal cancer cells, and this function is achieved through regulating the miR-577/FKBP14 axis.
Article
Oncology
Tomoya Takeda, Yuuta Yamamoto, Masanobu Tsubaki, Takuya Matsuda, Akihiro Kimura, Natsumi Shimo, Shozo Nishida
Summary: This study found that YAP protein is associated with migration and invasion of CRC cells. Silencing YAP expression or using a drug to inhibit YAP can suppress the migration and invasion of CRC cells.
Article
Biotechnology & Applied Microbiology
Min Feng, Ningfei Dong, Xin Zhou, Lihong Ma, Rui Xiang
Summary: MYL9 promotes the proliferation, invasion, migration, and angiogenesis of colorectal cancer cells by binding to YAP1 and activating Hippo signaling.
