BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

(2019) Marion Pardons et al.   PLoS Pathogens

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

(2019) Heidi M. Haikala et al.   Nature Communications

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Have Cells Harboring the HIV Reservoir Been Immunoedited?

(2019) Szu-Han Huang et al.   Frontiers in Immunology

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 + T Cells

(2018) Hsiao-Hsuan Kuo et al.   IMMUNITY

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

(2018) Szu-Han Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome

(2018) Sekar Natesampillai et al.   JOURNAL OF VIROLOGY

Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system

(2018) Kiera L. Clayton et al.   NATURE IMMUNOLOGY

Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

(2018) John F. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

(2018) Zheng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

(2018) Marilina García-Aranda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition

(2017) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Identification of essential genes for cancer immunotherapy

(2017) Shashank J. Patel et al.   NATURE

Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo

(2017) Stephan Halle et al.   TRENDS IN IMMUNOLOGY

Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus

(2016) Laura J. Martins et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Functionally Active HIV-Specific T Cells that Target Gag and Nef Can Be Expanded from Virus-Naïve Donors and Target a Range of Viral Epitopes: Implications for a Cure Strategy after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) Shabnum Patel et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CD8 + Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

(2016) Emily K. Cartwright et al.   IMMUNITY

HIV-specific CD8+ T cells and HIV eradication

(2016) R. Brad Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

(2016) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

(2016) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly-specific Cytotoxic T Cells Targeting Multiple HIV Antigens Are Expanded From HIV+ Patients: Implications for Immunotherapy

(2015) Sharon Lam et al.   MOLECULAR THERAPY

Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

(2015) Ruian Ke et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage

(2013) A. Cohnen et al.   BLOOD

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Emerging strategies to deplete the HIV reservoir

(2013) Nancie M. Archin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Susceptibility to CD8 T-Cell–Mediated Killing Influences the Reservoir of Latently HIV-1–Infected CD4 T Cells

(2013) Maria J. Buzon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8+ T-Cell Antiviral Activity and Correlates with Preservation of the CD4+ T-Cell Compartment

(2013) G. Turk et al.   JOURNAL OF VIROLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Shock and kill

(2012) Steven G. Deeks   NATURE

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

(2011) Adam R Hersperger et al.   Current Opinion in HIV and AIDS

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

(2010) Alberto Bosque et al.   METHODS

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY