Article
Biochemistry & Molecular Biology
Ernestini Tyfoxylou, Nick Voulgaris, Chris Gravvanis, Sophia Vlachou, Athina Markou, Labrini Papanastasiou, Nikolaos Tentolouris, Eva Kassi, Gregory Kaltsas, George P. Chrousos, George P. Piaditis
Summary: This study aimed to investigate the prevalence of PA and exaggerated aldosterone response to stress in patients with DM-2, and found that a significant proportion of DM-2 patients had PA or an exaggerated aldosterone response to stress. Treatment with MRAs effectively reduced blood pressure.
Article
Endocrinology & Metabolism
Saba S. Memon, Anurag Lila, Rohit Barnabas, Manjunath Goroshi, Vijaya Sarathi, Vyankatesh Shivane, Virendra Patil, Nalini Shah, Tushar Bandgar
Summary: The study aims to assess the prevalence of primary aldosteronism (PA) in Asian Indian patients with Type 2 diabetes mellitus (T2DM) and hypertension, revealing that a significant number of patients tested positive for PA, showing higher levels of uncontrolled blood pressure and more severe disease conditions compared to those without PA. Further research is needed to evaluate the cost-effectiveness of routine screening for PA in this population.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fabio Bioletto, Martina Bollati, Chiara Lopez, Stefano Arata, Matteo Procopio, Federico Ponzetto, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: Primary aldosteronism is recognized as the most common cause of secondary hypertension, associated with high-risk phenotypes and increased cardiovascular morbidity. Excessive aldosterone secretion can contribute to the development of hypertension and drug resistance through various mechanisms and worsen end-organ damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kiyotaka Itcho, Kenji Oki, Haruya Ohno, Masayasu Yoneda
Summary: Primary aldosteronism (PA) is the most common form of secondary hypertension, with two main subtypes: aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism. Recent advancements in genetic analysis have led to the discovery of mutations in causative genes, contributing to a better understanding of the mechanism of excess aldosterone synthesis.
Article
Endocrinology & Metabolism
Ahmed Saadi, Mohamed Ali Bedoui, Selim Zaghbib, Hamza Boussaffa, Seif Mokaddem, Ibtissem Ben Nacef, Haroun Ayed, Amine Derouiche, Karima Khiari, Marouene Chakroun, Riadh Ben Slama
Summary: This study retrospectively analyzed the medical records of 71 Tunisian patients who underwent surgery for UPA. The complete clinical success rate was 48% and the partial clinical success rate was 43%. Absence of diabetes, low BMI, high plasma ARR, and high ARS were identified as the main predictors of complete resolution of hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Niki Mourtzi, Amalia Sertedaki, Athina Markou, George P. Piaditis, Evangelia Charmandari
Summary: Recent genetic studies have made significant progress in understanding primary aldosteronism, with the identification of various mutations associated with both sporadic and familial forms of the disease. The prevalence of PA is higher than previously thought, highlighting the need for improved diagnostic tools and further research to identify milder forms of the condition and explore underlying molecular mechanisms.
Article
Peripheral Vascular Disease
James M. Luther, Dawei S. Wei, Kakali Ghoshal, Dungeng Peng, Gail K. Adler, Adina F. Turcu, Hui Nian, Chang Yu, Carmen C. Solorzano, Ambra Pozzi, Nancy J. Brown
Summary: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules generated by the action of CYP450s, with vasodilatory, anti-inflammatory, and insulin-enhancing effects. Treatment of primary aldosteronism led to an increase in EET concentrations, particularly 14,15-DHETs.
Review
Endocrinology & Metabolism
Suranut Charoensri, Adina F. F. Turcu
Summary: Primary aldosteronism (PA) is a common cause of secondary hypertension and can lead to cardiovascular and renal complications if left untreated. The exact disease burden of PA remains challenging to determine due to variations in testing and population studied. This review highlights the impact of rigid versus permissive criteria on the perception of PA prevalence.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Endocrinology & Metabolism
Sho Katsuragawa, Yuya Tsurutani, Tomoko Takiguchi, Jun Saito, Tetsuo Nishikawa
Summary: The study found that primary aldosteronism (PA) is an independent risk factor for renal dysfunction in patients with type 2 diabetes mellitus. Patients with PA had significantly lower estimated glomerular filtration rates compared to those without PA, indicating the importance of recognizing and addressing PA in preventing the progression of renal failure.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Chun-Kai Chang, Chin-Chen Chang, Vin-Cent Wu, Jiun-Hung Geng, Hsiang-Ying Lee
Summary: This study revealed a strong association between primary aldosteronism (PA) and renal stones, with PA-related renal stones being larger and harder than those in the essential hypertension group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Josephine McCarthy, Jun Yang, Ben Clissold, Morag J. Young, Peter J. Fuller, Thanh Phan
Summary: Primary aldosteronism carries a higher risk of stroke, atrial fibrillation, and cardiovascular disease compared to essential hypertension. While there are targeted treatments and potentially curative surgical options for primary aldosteronism, there is a lack of guidelines for screening and diagnosing the condition in stroke patients with hypertension. However, accurate diagnosis of primary aldosteronism could lead to improved blood pressure control and reduced cardiovascular risk in this population.
Article
Endocrinology & Metabolism
Xinyu Liu, Chao Guo, Jin Bian, Sufang Hao, Ying Lou, Huimin Zhang, Xianliang Zhou, Jun Cai, Wenjun Ma
Summary: The study aimed to examine the consistency of plasma aldosterone concentration at 1 and 2 hours in the captopril challenge test (CCT) and explore the possibility of replacing 2-hour aldosterone concentration with 1-hour aldosterone concentration for diagnosing primary aldosteronism (PA). The results showed that using 1-hour aldosterone concentration with 11 ng/dl as the cutoff, the sensitivity and specificity for diagnosing PA were 87.2% and 78.2%, respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Shivaraj Patil, Chaitanya Rojulpote, Aman Amanullah
Summary: Cardiovascular disease, especially ischemic heart disease, is a major global cause of illness and death. Primary aldosteronism is the main cause of secondary hypertension, but it is often under-diagnosed. Recent studies have shown that excessive production of aldosterone is associated with an increased risk of ischemic heart disease, which is disproportionate to the effects caused by hypertension alone. Understanding primary hyperaldosteronism and the distinctive pathophysiology of ischemic heart disease in this condition is crucial for improving outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Summary: This study aimed to assess the prevalence and risk factors of type-2 DM in Ethiopian population. The pooled prevalence of DM in Ethiopia was 6.5%, with identified risk factors including older age, illiteracy, cigarette smoking, MBI >= 25, family history of DM, history of hypertension, and physical inactivity. Awareness of these risk factors is crucial for effective prevention and management of type-2 DM in this population.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Minjae Yoon, Namki Hong, Jaehyung Ha, Chan Joo Lee, Cheol Ryong Ku, Yumie Rhee, Sungha Park
Summary: This study evaluated the prevalence and clinical characteristics of primary aldosteronism in Korean hypertension patients. The results showed a higher prevalence of primary aldosteronism among Korean hypertensive patients than previously recognized, and it was associated with more severe target organ damage and higher blood pressure levels.
HYPERTENSION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wei Liu, Jingjing Zhang, Yaling Yang, Yinxin Jin, Zaizhao Li, Liting You, Jianguang Luo, Xin Su
Summary: The aim of this study was to investigate the usefulness of metanephrine (MN) and normetanephrine (NMN) in bilateral simultaneous adrenal vein sampling (AVS) with and without ACTH stimulation. The results showed that MN is the best index for determining the catheterization selectivity in AVS, especially in the absence of ACTH stimulation.
HORMONE AND METABOLIC RESEARCH
(2022)