Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Clinical Neurology
Anette-Eleonore Schrag, Davide Martino, Hanyuying Wang, Gareth Ambler, Noa Benaroya-Milstein, Maura Buttiglione, Francesco Cardona, Roberta Creti, Androulla Efstratiou, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Pablo Mir, Astrid Morer, Natalie Moll, Norbert E. Muller, Kirsten R. Muller-Vahl, Kerstin J. Plessen, Cesare Porcelli, Renata Rizzo, Veit Roessner, Markus Schwarz, Zsanett Tarnok, Susanne Walitza, Andrea Dietrich, Pieter J. Hoekstra
Summary: This study aimed to investigate the association between group A streptococcal (GAS) infections and tic incidence among unaffected children with a family history of chronic tic disorders (CTDs). Findings showed a strong association between sex and tic onset, with girls having a lower risk of developing tics compared to boys. However, there was no statistical evidence to suggest an association between GAS exposure and tic onset.
Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Daniel A. Geller, Saffron Homayoun, Gabrielle Johnson
Summary: Early onset of Obsessive Compulsive Disorder (OCD) may represent a unique developmental subtype of the disorder, with several age-related factors identified by research. Early diagnosis and intervention in affected youth are crucial to reduce the functional impairments caused by untreated illness.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Masanori Isobe, Matilde Vaghi, Naomi A. Fineberg, Annemieke M. Apergis-Schoute, Edward T. Bullmore, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: The study demonstrates a link between cognitive inflexibility and putamen morphology in OCD patients and their relatives, indicating a familial marker of OCD. The findings suggest a shared abnormality in basal ganglia structure associated with cognitive rigidity among individuals with OCD and their asymptomatic relatives.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Psychology, Clinical
Behrang Mahjani, Katharina Bey, Julia Boberg, Christie Burton
Summary: Obsessive-compulsive disorder (OCD) is a heritable, polygenic disorder with contributions from both common and rare genetic variants. Genetics play an important role in the susceptibility to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide studies show that OCD shares genetic risk with its comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Prerika Sharma, Maria C. Rosario, Ygor A. Ferrao, Lucy Albertella, Euripedes C. Miguel, Leonardo F. Fontenelle
Summary: This study investigated the characteristics of patients with comorbid generalized anxiety disorder (GAD) and obsessive-compulsive disorder (OCD), and found that comorbid GAD was associated with an increased number of avoidant behaviors and greater severity of anxiety.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Antonella Gagliano, Alessandra Carta, Marcello G. Tanca, Stefano Sotgiu
Summary: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by a constellation of acute symptoms followed by a chronic course. Recent research has focused on clinical and pathophysiological aspects of PANS, as well as strategies for disease management. The importance of a comprehensive approach to treatment and the role of neuro-inflammation in psychiatric disorders are highlighted. This article is rated 7 out of 10 in terms of importance.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Psychology, Multidisciplinary
Faranak Kadivari, Mahmoud Najafi, Vahid Khosravani
Summary: This study found that childhood maltreatment has both direct and indirect effects on obsessive-compulsive symptoms, with the indirect effect mediated by the behavioral inhibition system. The findings highlight the role of the behavioral inhibition system in linking childhood maltreatment to obsessive-compulsive symptomology.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Behavioral Sciences
Emily A. Troyer, Jordan N. Kohn, Gertrude Ecklu-Mensah, Gajender Aleti, David R. Rosenberg, Suzi Hong
Summary: Research supports further exploration of immune-microbiome signaling in OCD, with evidence including: 1) associations between gut microbiota and OCD, though causal mechanisms are unclear; 2) overlap of early environmental risk factors for OCD with critical periods of immune-microbiome development; 3) increased risk of immune-mediated disorders and changes in immune parameters in OCD, which are related to the microbiome; and 4) manipulations of the gut microbiome in animal models leading to changes in immunity and obsessive-compulsive symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Lingxiao Cao, Hailong Li, Xinyu Hu, Jing Liu, Yingxue Gao, Kaili Liang, Lianqing Zhang, Xinyue Hu, Xuan Bu, Lu Lu, Yanlin Wang, Shi Tang, Qiyong Gong, Xiaoqi Huang
Summary: This study aimed to identify pathophysiological specifics in OCD with different onset times by assessing amygdala subregional functional connectivity alterations. The findings emphasized different patterns of amygdala subregional connectivity alterations associated with EO-OCD and LO-OCD patients, providing unique insights into constructing distinct OCD subtypes based on brain intrinsic connectivity. Specific management for EO-OCD and LO-OCD patients may be needed based on these results.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Obstetrics & Gynecology
Lai-Ling Chan, Tsz-Kin Lo, Wai-Lam Lau, Samuel Lau, Bassanio Law, Hin-Hung Tsang, Wing-Cheong Leung
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2013)
Letter
Pediatrics
Avis Chan, Jennifer Frankovich
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2019)
Article
Rheumatology
Anne McHugh, Avis Chan, Carolyn Herrera, Jennifer M. Park, Imelda Balboni, Dana Gerstbacher, Joyce J. Hsu, Tzielan Lee, Margo Thienemann, Jennifer Frankovich
Summary: This study aimed to evaluate emotional and behavioral symptoms in children with juvenile spondyloarthritis (SpA) and polyarticular arthritis (PolyA) and investigate the relationship between these symptoms and disease activity. The results showed that more active disease was associated with worse psychological functioning and more internalized emotional disturbances.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Avis L. Chan, Nan Guo, Rita Popat, Thalia Robakis, Yair Y. Blumenfeld, Elliott Main, Karen A. Scott, Alexander J. Butwick
Summary: This retrospective cohort study using data from the Office of Statewide Planning and Development in California found that Black women had the highest cumulative incidence of hospital-based care for postpartum depression, while Asian women had the lowest. Compared with White women, Black women were more likely to receive hospital-based care for postpartum depression, while Asian and Hispanic women were less likely.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2021)
Review
Medicine, General & Internal
Vivian K. S. Ng, Avis L. Chan, W. L. Lau, W. C. Leung
HONG KONG MEDICAL JOURNAL
(2020)
Article
Biotechnology & Applied Microbiology
S. K. P. Lau, P. C. Y. Woo, R. Y. Y. Fan, S. S. L. Ma, W.-T. Hui, S.-Y. Au, L.-L. Chan, J. Y. F. Chan, A. T. K. Lau, K.-Y. Leung, T. C. T. Pun, H. H. L. She, C.-Y. Wong, L. L. L. Wong, K.-Y. Yuen
JOURNAL OF APPLIED MICROBIOLOGY
(2007)
