Correction
Oncology
Yao-Yin Li, Chuan-Xiang Zhou, Yan Gao
Summary: This article points out an error in Figure 7 and provides a corrected version. However, this error does not affect the interpretation of the figure and does not impact the conclusions of the study.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Cristina Stefania Dumitru, Amalia Raluca Ceausu, Nela Pusa Gaje, Cristian Silviu Suciu, Marius Raica
Summary: This study demonstrates the importance of double immunolabeling in assessing lymphangiogenesis and tumor proliferation in correlation with histopathological grades in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jun Suzuki, Keiju Aokage, Shinya Neri, Takashi Sakai, Hiroko Hashimoto, Yinghan Su, Shota Yamazaki, Hiroshi Nakamura, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiro Tsuboi, Genichiro Ishii
Summary: PDPN+ CAFs in lung squamous cell carcinoma showed higher TGFB1 expression and were associated with infiltration of CD204(+) TAMs, indicating that PDPN+ CAFs were related to the immunosuppressive tumor microenvironment.
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Zhi-Yun Liu, Chun-Guang Zhao
Summary: The study revealed that PDPN expression was enriched in TSCC tissues and cells, and its knockdown inhibited the viability, adhesive ability, and migratory capacity of TSCC cells. This effect could be reversed by the application of a miR-532-3p inhibitor, indicating a direct target relationship between miR-532-3p and PDPN.
CHINESE MEDICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Thomas Dittmar
Summary: CS/ICs play a crucial role in cancer research and therapy, but their complexity makes identification challenging. Cell-cell fusion could lead to the generation of tumor hybrids with different CS/IC properties, contributing to the heterogeneity of the CS/IC pool within tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jee-Eun Choi, Carlos Sebastian, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas LaSalle, Anna Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael S. Regan, Murat Cetinbas, Gloria Pascual, Gregory R. Wojtkiewicz, Giorgia G. Silveira, Ruben Boon, Kenneth N. Ross, Itay Tirosh, Srinivas V. Saladi, Leif W. Ellisen, Ruslan I. Sadreyev, Salvador Aznar Benitah, Nathalie Y. R. Agar, Nir Hacohen, Raul Mostoslavsky
Summary: The study highlights the important tumor suppressor role of NAD(+)-dependent histone deacetylase sirtuin 6 in squamous cell carcinoma, as well as the existence of a subset of highly glycolytic tumor-propagating cells with elevated antioxidant capacity. These findings emphasize the key role of metabolism in intra-tumor heterogeneity.
Article
Oncology
Masaki Shimizu, Yu-ichiro Koma, Hiroki Sakamoto, Shuichi Tsukamoto, Yu Kitamura, Satoshi Urakami, Kohei Tanigawa, Takayuki Kodama, Nobuhide Higashino, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: In this study, we found that MT2A plays a crucial role in the progression of ESCC, affecting the migration and invasiveness of tumor cells in CAF-like cells and cancer cells. MT2A and IGFBP2 may serve as potential novel therapeutic targets in ESCC.
Review
Pathology
Guorui Sun, Yanru Yang, Jin Liu, Zizhao Gao, Tianqi Xu, Jia Chai, Junpeng Xu, Zhenge Fan, Tian Xiao, Qingge Jia, Mingyang Li
Summary: This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Anatomy & Morphology
Xiao-Qin Liu, Yao Yao, Jing-Wen Mu, Feng-Ying Yang
Summary: This study found that high cytoplasmic expression of Sema4A is related to T classification, clinical stage, and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed higher microvessel density (MVD) and poorer prognosis in OSCC. Over-expression of Sema4A can inhibit the invasion, migration, and angiogenesis abilities of oral squamous cell carcinoma cells.
Article
Cell Biology
Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu
Summary: Research suggests that SOX2 functions as an oncogene in esophageal squamous cell carcinoma (ESCC). However, directly targeting SOX2 is not feasible due to its roles in tissue maintenance. This study identified CDP as a SOX2 binding partner enriched in ESCC and found that blocking the interaction between CDP and SOX2 with peptide aptamers, such as P58, inhibits ESCC progression. Synthetic peptide P58, containing a cell-penetrating peptide and a fluorophore, also demonstrated efficacy in blocking ESCC growth and metastasis in mice and zebrafish. Targeting the SOX2 binding partner CDP with peptide P58 provides an alternative approach to treating ESCC with increased SOX2 levels.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Review
Physiology
Keigo Machida
Summary: This article reviews the links between HCV-associated HCC and TICs, discussing how HCV promotes the genesis of TICs and the development of HCC, and how this process can be utilized as a novel therapeutic target for HCC treatment. Additionally, it introduces the ten hall marks of TIC oncogenesis and HCC development as targets for novel therapeutic modalities.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Veterinary Sciences
Shunsuke Noguchi, Asuka Matsui
Summary: This study aimed to investigate the molecular mechanisms underlying the migration and invasion of tonsillar squamous cell carcinoma (TSCC) cells. The study found that miR-203 expression was lower in TSCC tissues than in normal oral mucosa and non-tonsillar SCC (NTSCC) tissues. Transfection of miR-203 mimic inhibited cell migration and invasion in TSCC cells, but not in NTSCC cells. The study suggests that the miR-203/SLUG axis may be involved in the metastatic mechanisms of TSCC.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Oncology
Shinya Neri, Hiroko Hashimoto, Hiroaki Kii, Hirotada Watanabe, Kenkichi Masutomi, Takeshi Kuwata, Hiroshi Date, Masahiro Tsuboi, Koichi Goto, Atsushi Ochiai, Genichiro Ishii
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2016)
Review
Pharmacology & Pharmacy
Genichiro Ishii, Atsushi Ochiai, Shinya Neri
ADVANCED DRUG DELIVERY REVIEWS
(2016)
Article
Oncology
Takuya Ueda, Keiju Aokage, Hiroyoshi Nishikawa, Shinya Neri, Hiroshi Nakamura, Masato Sugano, Kenta Tane, Tomohiro Miyoshi, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiko Kusumoto, Kenji Suzuki, Masahiro Tsuboi, Genichiro Ishii
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2018)
Review
Pharmacology & Pharmacy
Yifan Wang, Weiye Deng, Nan Li, Shinya Neri, Amrish Sharma, Wen Jiang, Steven H. Lin
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Masayuki Ishibashi, Shinya Neri, Hiroko Hashimoto, Tomoyuki Miyashita, Tatsuya Yoshida, Yuka Nakamura, Hibiki Udagawa, Keisuke Kirita, Shingo Matsumoto, Shigeki Umemura, Kiyotaka Yoh, Seiji Niho, Masahiro Tsuboi, Kenkichi Masutomi, Koichi Goto, Atsushi Ochiai, Genichiro Ishii
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Tomoyuki Miyashita, Tomokazu Omori, Hiroshi Nakamura, Masato Sugano, Shinya Neri, Satoshi Fujii, Hiroko Hashimoto, Masahiro Tsuboi, Atsushi Ochiai, Genichiro Ishii
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Article
Oncology
Takashi Sakai, Keiju Aokage, Shinya Neri, Hiroshi Nakamura, Shogo Nomura, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Akira Iyoda, Masahiro Tsuboi, Genichiro Ishii
Article
Oncology
Shinya Neri, Toshi Menju, Terumasa Sowa, Yojiro Yutaka, Daisuke Nakajima, Masatsugu Hamaji, Akihiro Ohsumi, Toyofumi F. Chen-Yoshikawa, Toshihiko Sato, Makoto Sonobe, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date
Article
Oncology
Ismail M. Meraz, Mourad Majidi, Feng Meng, RuPing Shao, Min Jin Ha, Shinya Neri, Bingliang Fang, Steven H. Lin, Peggy T. Tinkey, Elizabeth J. Shpall, Jeffrey Morris, Jack A. Roth
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Cell Biology
Shoshi Hisamitsu, Tomoyuki Miyashita, Hiroko Hashimoto, Shinya Neri, Masato Sugano, Hiroshi Nakamura, Shota Yamazaki, Atsushi Ochiai, Koichi Goto, Masahiro Tsuboi, Genichiro Ishii
Article
Multidisciplinary Sciences
Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Bhanu Prasad Venkatesulu, Amrish Sharma, Julianne M. Pollard-Larkin, Ramaswamy Sadagopan, Jessica Symons, Shinya Neri, Pankaj K. Singh, Ramesh Tailor, Steven H. Lin, Sunil Krishnan
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Jun Suzuki, Keiju Aokage, Shinya Neri, Takashi Sakai, Hiroko Hashimoto, Yinghan Su, Shota Yamazaki, Hiroshi Nakamura, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiro Tsuboi, Genichiro Ishii
Summary: PDPN+ CAFs in lung squamous cell carcinoma showed higher TGFB1 expression and were associated with infiltration of CD204(+) TAMs, indicating that PDPN+ CAFs were related to the immunosuppressive tumor microenvironment.
Article
Oncology
Shinya Neri, Tomoyuki Miyashita, Hiroko Hashimoto, Yoshitaka Suda, Masayuki Ishibashi, Hiroaki Kii, Hirotada Watanabe, Takeshi Kuwata, Masahiro Tsuboi, Koichi Goto, Toshi Menju, Makoto Sonobe, Hiroshi Date, Atsushi Ochiai, Genichiro Ishii