Article
Medicine, Research & Experimental
Sanaa A. Ahmed, Walaa Mohammed
Summary: The present study demonstrates that CARV has a protective effect against aluminum chloride-induced testicular oxidative, inflammatory, and apoptosis damage, including modulation of biochemical parameters, protection of sperm count and motility, improvement of histopathological findings, and restoration of the expression levels of apoptotic-related genes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yilong Hao, Tao Ren, Xiaoke Huang, Mi Li, Jong-Ho Lee, Qianming Chen, Rui Liu, Qingfeng Tang
Summary: Exposure to ionizing radiation leads to oxidative damages in living cells. The pentose phosphate pathway (PPP) is the major route to produce NADPH in mammalian cells, and G6PD is the rate-limiting step of PPP. However, whether G6PD is timely co-opted under ionizing radiation to cope with oxidative stress remains elusive.
Article
Food Science & Technology
Mingyue Qu, Qican He, Baoshi Guo
Summary: Lycopene has a protective effect against testicular damage induced by ionizing radiation, and the mechanism may involve inhibition of the mitochondrial apoptotic pathway and maintenance of mitochondrial respiration and biogenesis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Mars G. Sharapov, Sergey Gudkov
Summary: The study aimed to investigate the radioprotective properties of exogenous Prx1 and found that recombinant Prx1 is an effective radioprotector which reduces the severity of radiation-induced leuko- and thrombocytopenia, and protects bone marrow cells from damage.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Immunology
Minghuan Zhu, Zhenjing Liu, Yanhong Guo, Mst Sadia Sultana, Kang Wu, Xiaoe Lang, Qinyu Lv, Xiao Huang, Zhenghui Yi, Zezhi Li
Summary: This study revealed gender differences in the relationship between TNF-alpha, MDA, and their interaction with psychopathological symptoms in patients with schizophrenia. Male patients showed higher MDA levels and specific associations between TNF-alpha, MDA levels, and psychotic symptoms compared to female patients.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Public, Environmental & Occupational Health
Ruan Gabriel Soares da Silva, Mariane Okamoto Ferreira, Isabella Mitsu Suo Komori, Henrique Rodrigues Menezes Oliveira, Murilo Galvani Machado, Julia Fernandes Gois Orrutea, Fernanda Mara Alves, Hellen dos Santos Jaques, Janaina Carla da Silva, Janoario Athanazio de Souza, Daniel Rech, Carolina Panis
Summary: Studies have shown a high incidence of various tumors, including breast cancer, in populations exposed to pesticides. This exposure is not only associated with direct DNA damage but also with epigenetic modifications and inflammation mediators, indicating genomic instability. The present study analyzed the inflammatory changes in the breast tissue of occupationally exposed women without cancer and found an inflammatory signature associated with pesticide exposure, which may trigger genetic mutations and breast carcinogenesis.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Mohamed Amr El-Missiry, Sameh Shabana, Sara J. Ghazala, Azza I. Othman, Maggie E. Amer
Summary: The study demonstrated that melatonin has potential neuroprotective properties in reducing inflammation, oxidative stress, and apoptosis in the brains of rats exposed to gamma radiation. This suggests that melatonin may have beneficial effects in clinical and occupational settings involving radiation exposure. Further research is needed to fully understand its neuroprotective effects in humans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Sihem Guesmi, Petar Pujic, Imen Nouioui, Audrey Dubost, Afef Najjari, Kais Ghedira, Jose M. Igual, Guylaine Miotello, Ameur Cherif, Jean Armengaud, Hans-peter Klenk, Philippe Normand, Haitham Sghaier
Summary: Isolate PT10, belonging to the genus Kocuria, is an IR-resistant actinobacterium capable of surviving under extreme conditions. Phenotypic, chemotaxonomic, and comparative genome analyses support its classification as Kocuria rhizophila.
Article
Cell Biology
Renfeng Xu, Siting Shen, Defan Wang, Jianqing Ye, Shiting Song, Zhengchao Wang, Zhicao Yue
Summary: Testicular injury and infertility are common adverse effects of radiation therapy. This study found that radiation can cause structural and functional damage to the testis, leading to decreased sperm count and increased apoptosis. Autophagy was also found to be involved in testicular cell apoptosis induced by radiation.
JOURNAL OF MOLECULAR HISTOLOGY
(2023)
Article
Neurosciences
Zakieh Keshavarzi, Sedigheh Amiresmaili, Nader Shahrokhi, Bahram Bibak, Farzane Shakeri
Summary: The study suggests that Auraptene may prevent complications of traumatic brain injury by reducing oxidative stress, decreasing levels of inflammatory cytokines, and inhibiting brain damage.
BRAIN RESEARCH BULLETIN
(2021)
Review
Neurosciences
Tapan Behl, Gagandeep Kaur, Aayush Sehgal, Gokhan Zengin, Sukhbir Singh, Amirhossein Ahmadi, Simona Bungau
Summary: This review examines the role of ionizing radiation-induced oxidative stress in Parkinson's disease and proposes novel therapeutic interventions using flavonoids, which can effectively manage and slow down the progression of the disease.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, An Wang, Changhao He, Zhongyu Shi, Shujing Zhang, Qian Fu, Wenhui Xu, Sumin Hu
Summary: This study confirmed the protective effects of YQJD decoction on ionizing radiation-induced spermatogenic cell injury. The findings may provide a new strategy for the application of Chinese herbs in radioprotection.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Fisheries
Xinxin Zheng, Changsheng Shao, Jianxia Zhu, Leisheng Zhang, Qing Huang
Summary: Through experiments on normal cells, it was found that astaxanthin can significantly enhance the cell viability under gamma-ray radiation conditions by reducing reactive oxygen species (ROS) in the cells and alleviating radiation-induced DNA damage. Furthermore, astaxanthin was found to activate the Nrf2 signaling pathway and upregulate antioxidant proteins HO-1 and p-Nrf2, which helps alleviate oxidative stress caused by ionizing radiation. This study not only provides evidence of the outstanding antioxidant properties of astaxanthin, but also expands its potential applications in radiation protection.
AQUACULTURE INTERNATIONAL
(2023)
Review
Cell Biology
Qin-Qi Wang, Gang Yin, Jiang-Rong Huang, Shi-Jun Xi, Feng Qian, Rui-Xue Lee, Xiao-Chun Peng, Feng-Ru Tang
Summary: Population aging poses challenges to the global economy and healthcare services. Brain aging, influenced by external factors like ionizing radiation, can lead to various neurological disorders. Treatment targeting radiation-induced oxidative stress and neuroinflammation may prevent radiation-induced brain aging and related neurological disorders.
Article
Biochemistry & Molecular Biology
Madhuri Basak, Kiran Das, Tarun Mahata, Abhishek Singh Sengar, Sumit Kumar Verma, Sayan Biswas, Kakali Bhadra, Adele Stewart, Biswanath Maity
Summary: This study investigates the role of RGS7 in hyperlipidemia-dependent hepatic dysfunction in NAFLD. RGS7 is found to be elevated in the livers of NAFLD patients and forms a complex with ATF3 and Tip60, contributing to NAFLD development. Knockdown of RGS7 protects against liver damage caused by high-fat diet, reversing steatosis and inflammation, and improving liver function.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Oncology
Nafie F. Makady, David Ramzy, Ramy Ghaly, Raafat R. Abdel-Malek, Kyrillus S. Shohdy
Summary: A systematic review of plasmablastic lymphoma showed a significant association between aggressive chemotherapy and better overall survival. Factors like stage, viral status, and site involvement were found to be related to overall survival outcomes.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2021)
Article
Multidisciplinary Sciences
Mahmoud A. Senousy, Aya M. El-Abd, Raafat R. Abdel-Malek, Sherine M. Rizk
Summary: In this study, plasma HOTAIR, GAS5, and XIST were introduced as potential non-invasive diagnostic tools for DLBCL, with HOTAIR and GAS5 identified as candidates for evaluating therapy response and HOTAIR as a predictor of R-CHOP failure. Protein-protein interaction networks linked to drug response were constructed through bioinformatics analysis, providing novel surrogates for future predictive studies in personalized medicine.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Ahmed O. Elmehrath, Ahmed M. Afifi, Raafat Abdel-Malek
Summary: Research on non-cancer death causes in ovarian cancer patients is limited, with a focus on evaluating the causes of non-cancer death after diagnosis. The study of 82,590 OC patients revealed that cardiac diseases, cerebrovascular diseases, and COPD were the most common non-cancer death causes, with mortality risk differences based on race and age. These findings provide critical insights for the follow-up and counseling of OC survivors for future health risks.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Maha Sabry, Seham Mostafa, Laila Rashed, Marwa Abdelgwad, Samaa Kamar, Suzanne Estaphan
Summary: This study found that induction of atherosclerosis via high fat diet led to a significant increase in MMP-9 levels in untreated rats, which correlated significantly with all measured parameters. Carvedilol and bisphosphonate had similar effects in restoring the measured parameters back to normal, partially or completely.
Meeting Abstract
Oncology
David Kaldas, Andrew Wahba, Radwa Hamdy Azab, Ehab Mostafa Elnakoury, Nagla Fawzy Abdel Karim, Raafat Abdel-Malek
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Viviane Delghingaro-Augusto, Ayumi Hosaka, Suzanne Estaphan, Alice Richardson, Jane E. Dahlstrom, Christopher J. Nolan
Summary: This study investigates the role of dietary iron in the development of inflammatory islet injury caused by intrauterine growth restriction (IUGR) and a Western diet (WD). The findings suggest that a high iron diet, independent of IUGR, contributes to acute pancreatitis and islet injury in rats.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Mary Naguib, Wael Abdel-Razek, Suzanne Estaphan, Eman Abdelsameea, Mohamed Abdel-Samiee, Nevine F. Shafik
Summary: This study found that PT20210 and FVL mutations are associated with liver fibrosis progression and liver function in chronic HCV patients, and can be used as predictive markers for early intervention.
Article
Education, Scientific Disciplines
Sarah J. Etherington, Andrew J. Moorhouse, Tamara M. Paravicini, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis, Task Task Force
Summary: A task force of physiology educators from 25 Australian universities reached a nationwide consensus on seven core concepts for physiology curricula, one of which is cell membrane. The cell membrane core concept was unpacked into four themes and 33 subthemes, covering the definition, structure, transport, and potentials of cell membranes. Most items were evaluated as essential or important, with cell membrane structure theme rated as relatively less important and membrane potential theme rated as the most difficult. The importance of cell membranes in biomedical education received strong support from Australian educators.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education & Educational Research
Benjamin J. Mead, Suzanne Estaphan, Gerry Corrigan
Summary: COVID-19 has brought about changes in the learning environment of medical schools, particularly in the way social studying and learning (SSL) is conducted. This study examines the impact of the learning environment transformation on SSL and the rationale behind any changes. The findings indicate that while there was no significant difference in the participation rate of SSL, students shifted from in-person to Zoom meetings due to practicality, convenience, and ease. Students continued participating in SSL for motivation and began participating for accountability, focus, and as a substitute for lost social interaction.
EDUCATION SCIENCES
(2023)
Article
Education, Scientific Disciplines
Christian Moro, Tracy Douglas, Ruben Phillips, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis, Task Force
Summary: Using the Delphi method, consensus was reached on seven core concepts of physiology, including the integration concept of cells, tissues, organs, and organ systems interacting to create and sustain life. A team of Australian physiology educators unpacked this core concept into hierarchical levels, identifying five themes and ten subthemes. The importance and difficulty levels of each theme and subtheme were rated by experienced physiology educators. The main theme of hierarchy was rated as essential and slightly difficult, while the other subthemes differed in importance and difficulty. Integration core concepts should be taught in the later semesters of a Physiology program.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Daniel Brown, Tanya Uebergang, Nicole Masters, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis
Summary: This article aims to unpack the core concept of substance movement within the human body, providing guidance for physiology teaching in tertiary education institutes in Australia. The concept introduces fundamental knowledge of the driving factors and applies them in physiological contexts. The importance of understanding this concept is widely acknowledged, but its difficulty varies among educators. The complexity of this concept is due to the underlying physical forces, and organizing it into subthemes can help prioritize learning activities.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Elizabeth A. H. Beckett, Voula Gaganis, Anthony J. Bakker, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis, Task Force
Summary: Australia-wide consensus was reached on seven core concepts of physiology, with homeostasis being one of the fundamental concepts for students to understand physiological regulatory mechanisms. A team of Australian educators unpacked the concept and identified 5 themes and 18 subthemes to simplify the components and improve learning and teaching of homeostasis.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Kathy Tangalakis, Louise Lexis, Deanne H. Hryciw, Michelle Towstoless, Anthony J. Bakker, Elizabeth Beckett, Daniel Brown, Melissa Cameron, Julia Choate, Lisa Chopin, Matthew B. Cooke, Tracy Douglas, Suzanne Estaphan, Sarah Etherington, Voula Gaganis, Andrew Moorhouse, Christian Moro, Tamara Paravicini, Ben Perry, Ruben Phillips, Christopher Scott, Gabrielle Todd, Tanya Uebergang, Glenn Wadley, Matthew Watt, Alan Hayes
Summary: Consensus has been reached on the core concepts of physiology in Australia through the Delphi method, and these concepts will be integrated into the curricula of Australian universities. The core concepts include Cell Membrane, Cell-Cell Communication, Movement of Substances, Structure and Function, Homeostasis, Integration, and Physiological Adaptation.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Ben D. Perry, Melissa S. Cameron, Matthew B. Cooke, Michelle Towstoless, Deanne H. Hryciw, Alan Hayes, Louise Lexis, Kathy Tangalakis, Task Force
Summary: The structure and function core concept of physiology was unpacked and validated by Australian educators, specifically focusing on the renal system.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Lisa K. Chopin, Julia Choate, Joseph A. Rathner, Michelle Towstoless, Alan Hayes, Deanne H. Hryciw, Louise Lexis, Kathy Tangalakis, Task Force
Summary: An Australia-wide consensus was reached on seven core concepts of physiology, one of which was cell-cell communication. Three physiology educators from a core concepts Delphi task force unpacked this core concept into seven different themes and 60 subthemes. Cell-cell communication, previously unpacked and validated, was modified for an Australian audience to include emerging knowledge and adapted to increase student accessibility.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
