4.5 Article

SARS-CoV-2 lgM/lgG antibody detection confirms the infection after three negative nucleic acid detection

Journal

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 24, Issue 14, Pages 8262-8265

Publisher

WILEY
DOI: 10.1111/jcmm.15275

Keywords

SARS; CoV-2; lgM/lgG antibody detection; novel coronavirus

Funding

  1. National Natural Science Foundation of China [81521001, 81870182]

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An ongoing outbreak of viral pneumonia was caused by a novel coronavirus in China in 2019. By March 19, over 200 thousand confirmed cases of SARS-CoV-2 infection and over 9000 deaths have been reported throughout the world. For this infectious disease, nucleic acid detection is still the gold standard for pathogenic detection. However, nucleic acid detection takes a long time and has relatively high false negative; therefore, we need urgently a convenient and accurate detection method to make up for this deficiency. In this article, we will show such technical characteristics of lgM/lgG serum antibody detection, compared with nucleic acid detection.

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