Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 24, Issue 12, Pages 6523-6533Publisher
WILEY
DOI: 10.1111/jcmm.15295
Keywords
biomarker; circRNA; exosome; fibrosis; renal disease
Categories
Funding
- National Natural Science Foundation of China [81570623, 81970584]
- Natural Science Foundation of Colleges and Universities in Anhui Province [KJ2017A179]
- Science and Technological Fund of Anhui Province for Outstanding Youth of China [1608085J07]
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Circular RNA (circRNA) is a newly described type of non-coding RNA. Active research is greatly enriching the current understanding of the expression and role of circRNA, and a large amount of evidence has implicated circRNA in the pathogenesis of certain renal diseases, such as renal cell carcinoma, acute kidney injury, diabetic nephropathy and lupus nephritis. Studies have found evidence that circRNAs regulate programmed cell death, invasion, and metastasis and serve as biomarkers in renal diseases. Recently, circRNAs were identified in exosomes secreted by the kidneys. Nevertheless, the function of circRNA in renal diseases remains ambiguous. Given that circRNAs are regulators of gene expression, they may be involved in the pathology of multiple renal diseases. Additionally, emerging evidence is showing that circulating circRNAs may serve as novel biomarkers for renal disease. In this review, we have summarized the identification, biogenesis, degradation, and functions of circRNA and have evaluated the roles of circRNA in renal diseases.
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