Journal
JOURNAL OF CELL BIOLOGY
Volume 219, Issue 8, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201907058
Keywords
-
Categories
Funding
- Deutscher Akademischer Austauschdienst stipend [57129429]
- Perspective Program (Boehringer Ingelheim Fonds)
- Deutsche Forschungsgemeinschaft [LI925/8-1, CRC877, BL 1186/4-1, CRC914 (TP A09)]
- National Institutes of Health, National Institute of General Medical Sciences [GM134083-01]
- Max Planck Institute of Biochemistry
Ask authors/readers for more resources
Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion and tissue organization. Although much has been reported about their function in remodeling ECM in health and disease, their trafficking across the Golgi apparatus remains poorly understood. Here we report that the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus. This process is Ca(2+)dependent and is required for invasive MDA-MB-231 cell migration as well as for gelatin degradation in primary human macrophages. Our findings emphasize the importance of NUCB1 as an essential component of MMP transport and its overall impact on ECM remodeling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available